Multidisciplinary management of nonresectable hepatocellular carcinoma

Hee Chul Park, Jinsil Seong, Masatoshi Tanaka, Zhao Chong Zeng, Ho Yeong Lim, Sheng Guan, Si Hyun Bae, Won Young Tak

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

This article summarizes the consensus of an early morning workshop on the multidisciplinary management of nonresectable hepatocellular carcinoma (HCC) held on July 4, 2010, under the auspices of the 1st Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE) Scientific Advisory Committee. Important points are as follows: (1) nonresectable HCC consists of locally advanced HCC and HCC with extrahepatic spread. The grouping system for locally advanced HCC comprises the following categories: nodular, massive with intrahepatic metastases, diffuse, and disease with vascular invasion. (2) In actual clinical practice, the orchestration of multimodality treatment options is keenly needed for successful treatment of individual patients with nonresectable HCC. Physicians in charge tend to prefer maximal cytoreductive measures as long as the condition of the individual patient allows. (3) There are a few studies on the combined use of radiation therapy and transcatheter arterial chemoembolization or hepatic arterial infusion chemotherapy in the form of phase I and II trials. (4) At this stage, scientific evidence on multidisciplinary management of nonresectable HCC is lacking. Further studies on multidisciplinary management should focus on the subcategory of locally advanced HCC. (5) Further discussion is needed in the upcoming APPLE meeting to clarify the guidelines as well as to determine a practical multidisciplinary approach for nonresectable HCC patients.

Original languageEnglish
Pages (from-to)134-140
Number of pages7
JournalOncology
Volume81
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2011 Dec 1

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Hepatocellular Carcinoma
Liver Neoplasms
Advisory Committees
Vascular Diseases
Radiotherapy
Guidelines
Neoplasm Metastasis
Physicians
Education
Drug Therapy
Liver
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Park, H. C., Seong, J., Tanaka, M., Zeng, Z. C., Lim, H. Y., Guan, S., ... Tak, W. Y. (2011). Multidisciplinary management of nonresectable hepatocellular carcinoma. Oncology, 81(SUPPL. 1), 134-140. https://doi.org/10.1159/000333276
Park, Hee Chul ; Seong, Jinsil ; Tanaka, Masatoshi ; Zeng, Zhao Chong ; Lim, Ho Yeong ; Guan, Sheng ; Bae, Si Hyun ; Tak, Won Young. / Multidisciplinary management of nonresectable hepatocellular carcinoma. In: Oncology. 2011 ; Vol. 81, No. SUPPL. 1. pp. 134-140.
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Park, HC, Seong, J, Tanaka, M, Zeng, ZC, Lim, HY, Guan, S, Bae, SH & Tak, WY 2011, 'Multidisciplinary management of nonresectable hepatocellular carcinoma', Oncology, vol. 81, no. SUPPL. 1, pp. 134-140. https://doi.org/10.1159/000333276

Multidisciplinary management of nonresectable hepatocellular carcinoma. / Park, Hee Chul; Seong, Jinsil; Tanaka, Masatoshi; Zeng, Zhao Chong; Lim, Ho Yeong; Guan, Sheng; Bae, Si Hyun; Tak, Won Young.

In: Oncology, Vol. 81, No. SUPPL. 1, 01.12.2011, p. 134-140.

Research output: Contribution to journalReview article

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Park HC, Seong J, Tanaka M, Zeng ZC, Lim HY, Guan S et al. Multidisciplinary management of nonresectable hepatocellular carcinoma. Oncology. 2011 Dec 1;81(SUPPL. 1):134-140. https://doi.org/10.1159/000333276