Multifaceted Roles of Interleukin-6 in Adipocyte–Breast Cancer Cell Interaction

Jones Gyamfi, Minseob Eom, Ja Seung Koo, Junjeong Choi

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Breast cancer is the most common malignancy in women worldwide, with a developmental process spanning decades. The malignant cells recruit a variety of cells including fibroblasts, endothelial cells, immune cells, and adipocytes, creating the tumor microenvironment. The tumor microenvironment has emerged as active participants in breast cancer progression and response to treatment through autocrine and paracrine interaction with the malignant cells. Adipose tissue is abundant in the breast cancer microenvironment; interactions with cancer cells create cancer-associated adipocytes which produce a variety of adipokines that influence breast cancer initiation, metastasis, angiogenesis, and cachexia. Interleukin (IL)-6 has emerged as key compound significantly produced by breast cancer cells and adipocytes, with the potential of inducing proliferation, epithelial-mesenchymal phenotype, stem cell phenotype, angiogenesis, cachexia, and therapeutic resistance in breast cancer cells. Our aim is to present a brief knowledge of IL-6’s role in breast cancer. This review summarizes our current understanding of the breast microenvironment, with emphasis on adipocytes as key players in breast cancer tumorigenesis. The effects of key adipocytes such as leptin, adipokines, TGF-b, and IL-6 are discussed. Finally, we discuss the role of IL-6 in various aspects of cancer progression.

Original languageEnglish
Pages (from-to)275-285
Number of pages11
JournalTranslational Oncology
Volume11
Issue number2
DOIs
Publication statusPublished - 2018 Apr

Fingerprint

Cell Communication
Interleukin-6
Breast Neoplasms
Adipocytes
Tumor Microenvironment
Neoplasms
Cachexia
Adipokines
Phenotype
Interleukins
Leptin
Mesenchymal Stromal Cells
Adipose Tissue
Carcinogenesis
Breast
Endothelial Cells
Fibroblasts
Neoplasm Metastasis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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abstract = "Breast cancer is the most common malignancy in women worldwide, with a developmental process spanning decades. The malignant cells recruit a variety of cells including fibroblasts, endothelial cells, immune cells, and adipocytes, creating the tumor microenvironment. The tumor microenvironment has emerged as active participants in breast cancer progression and response to treatment through autocrine and paracrine interaction with the malignant cells. Adipose tissue is abundant in the breast cancer microenvironment; interactions with cancer cells create cancer-associated adipocytes which produce a variety of adipokines that influence breast cancer initiation, metastasis, angiogenesis, and cachexia. Interleukin (IL)-6 has emerged as key compound significantly produced by breast cancer cells and adipocytes, with the potential of inducing proliferation, epithelial-mesenchymal phenotype, stem cell phenotype, angiogenesis, cachexia, and therapeutic resistance in breast cancer cells. Our aim is to present a brief knowledge of IL-6’s role in breast cancer. This review summarizes our current understanding of the breast microenvironment, with emphasis on adipocytes as key players in breast cancer tumorigenesis. The effects of key adipocytes such as leptin, adipokines, TGF-b, and IL-6 are discussed. Finally, we discuss the role of IL-6 in various aspects of cancer progression.",
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Multifaceted Roles of Interleukin-6 in Adipocyte–Breast Cancer Cell Interaction. / Gyamfi, Jones; Eom, Minseob; Koo, Ja Seung; Choi, Junjeong.

In: Translational Oncology, Vol. 11, No. 2, 04.2018, p. 275-285.

Research output: Contribution to journalReview article

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