Multifunctional dendritic nanoparticles as a nanomedicine platform

Hao Jui Hsu, Ryan M. Pearson, Seungpyo Hong

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Dendrimers are a class of well-defined, highly branched, multifunctional polymeric nanomaterials that have been largely studied as delivery platforms to target therapeutics or diagnostics to various sites of interest. In this chapter, we systematically describe the use of dendrimers for biomedical applications and how their physicochemical properties can be tuned to achieve desired outcomes in areas such as drug and gene delivery, anti-pathogen, and diagnostics. Furthermore, we introduce dendritic polymers and how their unique properties merge advantageous properties of dendrimers with other drug delivery platforms such as linear-block polymers and liposomes to improve biological responses. Several examples of the use of dendrimers and dendritic polymers will be detailed with the objective to reveal critical nanocarriers design features to achieve specific delivery goals. Although challenges still remain to be addressed to enable the clinical translation of this nanotechnology, it is clear that the future for dendritic nanomaterials is highly promising.

Original languageEnglish
Title of host publicationFrontiers in Nanobiomedical Research
PublisherWorld Scientific Publishing Co. Pte Ltd
Pages155-186
Number of pages32
DOIs
Publication statusPublished - 2018 Jan 1

Publication series

NameFrontiers in Nanobiomedical Research
Volume11
ISSN (Print)2251-3965

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Medicine (miscellaneous)
  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry
  • Cancer Research

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  • Cite this

    Hsu, H. J., Pearson, R. M., & Hong, S. (2018). Multifunctional dendritic nanoparticles as a nanomedicine platform. In Frontiers in Nanobiomedical Research (pp. 155-186). (Frontiers in Nanobiomedical Research; Vol. 11). World Scientific Publishing Co. Pte Ltd. https://doi.org/10.1142/9789813222557_0005