Abstract
Dendrimers are a class of well-defined, highly branched, multifunctional polymeric nanomaterials that have been largely studied as delivery platforms to target therapeutics or diagnostics to various sites of interest. In this chapter, we systematically describe the use of dendrimers for biomedical applications and how their physicochemical properties can be tuned to achieve desired outcomes in areas such as drug and gene delivery, anti-pathogen, and diagnostics. Furthermore, we introduce dendritic polymers and how their unique properties merge advantageous properties of dendrimers with other drug delivery platforms such as linear-block polymers and liposomes to improve biological responses. Several examples of the use of dendrimers and dendritic polymers will be detailed with the objective to reveal critical nanocarriers design features to achieve specific delivery goals. Although challenges still remain to be addressed to enable the clinical translation of this nanotechnology, it is clear that the future for dendritic nanomaterials is highly promising.
| Original language | English |
|---|---|
| Title of host publication | Frontiers in Nanobiomedical Research |
| Publisher | World Scientific Publishing Co. Pte Ltd |
| Pages | 155-186 |
| Number of pages | 32 |
| DOIs | |
| Publication status | Published - 2018 Jan 1 |
Publication series
| Name | Frontiers in Nanobiomedical Research |
|---|---|
| Volume | 11 |
| ISSN (Print) | 2251-3965 |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Medicine (miscellaneous)
- Biochemistry
- Molecular Biology
- Clinical Biochemistry
- Cancer Research
Cite this
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Multifunctional dendritic nanoparticles as a nanomedicine platform. / Hsu, Hao Jui; Pearson, Ryan M.; Hong, Seungpyo.
Frontiers in Nanobiomedical Research. World Scientific Publishing Co. Pte Ltd, 2018. p. 155-186 (Frontiers in Nanobiomedical Research; Vol. 11).Research output: Chapter in Book/Report/Conference proceeding › Chapter
TY - CHAP
T1 - Multifunctional dendritic nanoparticles as a nanomedicine platform
AU - Hsu, Hao Jui
AU - Pearson, Ryan M.
AU - Hong, Seungpyo
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Dendrimers are a class of well-defined, highly branched, multifunctional polymeric nanomaterials that have been largely studied as delivery platforms to target therapeutics or diagnostics to various sites of interest. In this chapter, we systematically describe the use of dendrimers for biomedical applications and how their physicochemical properties can be tuned to achieve desired outcomes in areas such as drug and gene delivery, anti-pathogen, and diagnostics. Furthermore, we introduce dendritic polymers and how their unique properties merge advantageous properties of dendrimers with other drug delivery platforms such as linear-block polymers and liposomes to improve biological responses. Several examples of the use of dendrimers and dendritic polymers will be detailed with the objective to reveal critical nanocarriers design features to achieve specific delivery goals. Although challenges still remain to be addressed to enable the clinical translation of this nanotechnology, it is clear that the future for dendritic nanomaterials is highly promising.
AB - Dendrimers are a class of well-defined, highly branched, multifunctional polymeric nanomaterials that have been largely studied as delivery platforms to target therapeutics or diagnostics to various sites of interest. In this chapter, we systematically describe the use of dendrimers for biomedical applications and how their physicochemical properties can be tuned to achieve desired outcomes in areas such as drug and gene delivery, anti-pathogen, and diagnostics. Furthermore, we introduce dendritic polymers and how their unique properties merge advantageous properties of dendrimers with other drug delivery platforms such as linear-block polymers and liposomes to improve biological responses. Several examples of the use of dendrimers and dendritic polymers will be detailed with the objective to reveal critical nanocarriers design features to achieve specific delivery goals. Although challenges still remain to be addressed to enable the clinical translation of this nanotechnology, it is clear that the future for dendritic nanomaterials is highly promising.
UR - http://www.scopus.com/inward/record.url?scp=85035331940&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85035331940&partnerID=8YFLogxK
U2 - 10.1142/9789813222557_0005
DO - 10.1142/9789813222557_0005
M3 - Chapter
T3 - Frontiers in Nanobiomedical Research
SP - 155
EP - 186
BT - Frontiers in Nanobiomedical Research
PB - World Scientific Publishing Co. Pte Ltd
ER -