Multifunctional magnetic nanoparticles modified with polyethylenimine and folic acid for biomedical theranostics

Hyunhee Yoo, Seung Kwan Moon, Taewon Hwang, Yong Seok Kim, Joo Hwan Kim, Sung Wook Choi, Jung Hyun Kim

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

This paper describes the preparation of magnetic nanoparticles modified with polyethylenimine (PEI)-folic acid (PF) conjugate and their potential biomedical applications. Magnetic nanoparticles modified with (3-(2-aminoethylamino)propyltrimethoxysilane) (AEAPS) were first prepared using a ligand exchange method to provide biocompatibility and hydrophilicity, and further conjugated with PF to carry gene and enhance specific uptake into cancer cells. We demonstrated the feasibility of the multifunctional magnetic nanoparticles as contrast agents in magnetic resonance imaging (MRI) and as gene carriers for gene delivery. In vitro results revealed that the cytotoxicity of the multifunctional magnetic nanoparticles was lower compared to that of pristine magnetic nanoparticles. Furthermore, we demonstrated the specific uptake of the magnetic nanoparticles modified with PF to KB cells using WI-38 cells as comparison by confocal microscopy. The PF-modified magnetic nanoparticles can potentially be employed as theranostic nanoplatforms for targeted gene delivery to cancer cells and simultaneous magnetic resonance imaging.

Original languageEnglish
Pages (from-to)5962-5967
Number of pages6
JournalLangmuir
Volume29
Issue number20
DOIs
Publication statusPublished - 2013 May 21

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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