Multifunctional nanoparticles for photothermally controlled drug delivery and magnetic resonance imaging enhancement

Huiyul Park, Jaemoon Yang, Sungbaek Seo, Kyujung Kim, Jinsuk Suh, Donghyun Kim, Seungjoo Haam, Kyung Hwa Yoo

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

The use of biodegradable polymer-metal multilayer half-shell nanoparticles (H-S NPs) for photothermally controlled drug delivery and magnetic resonance imaging enhancement, was analyzed. The drug is encapsulated within biocompatible and biodegradable polymer nanoparticles, where metal multilayers are deposited on these nanoparticles. The absorption spectra was measured of the nanoparticle using a UV-visible/NIR spectrometer for poly(lactic-co-glycolic acid) (PLGA)-Au H-S NPs. The optical and photothermal conversion properties of rhodamine-loaded PLGA-Au H-S NPs with PLGA nanoparticles were examined. Rhodamine release was monitored from PLGA nanoparticles using total internal reflection fluorescence microscopy (TIRFM). Results show that these nanoparticles can efficiently achieve their selective cell target.

Original languageEnglish
Pages (from-to)192-196
Number of pages5
JournalSmall
Volume4
Issue number2
DOIs
Publication statusPublished - 2008 Feb 1

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Controlled drug delivery
Magnetic resonance
Nanoparticles
Magnetic Resonance Imaging
Imaging techniques
Pharmaceutical Preparations
Biodegradable polymers
Rhodamines
Acids
Polymers
Multilayers
Metal Nanoparticles
Metal nanoparticles
Fluorescence microscopy
Fluorescence Microscopy
Spectrometers
Absorption spectra
Metals
polylactic acid-polyglycolic acid copolymer
Milk

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

Cite this

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abstract = "The use of biodegradable polymer-metal multilayer half-shell nanoparticles (H-S NPs) for photothermally controlled drug delivery and magnetic resonance imaging enhancement, was analyzed. The drug is encapsulated within biocompatible and biodegradable polymer nanoparticles, where metal multilayers are deposited on these nanoparticles. The absorption spectra was measured of the nanoparticle using a UV-visible/NIR spectrometer for poly(lactic-co-glycolic acid) (PLGA)-Au H-S NPs. The optical and photothermal conversion properties of rhodamine-loaded PLGA-Au H-S NPs with PLGA nanoparticles were examined. Rhodamine release was monitored from PLGA nanoparticles using total internal reflection fluorescence microscopy (TIRFM). Results show that these nanoparticles can efficiently achieve their selective cell target.",
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Multifunctional nanoparticles for photothermally controlled drug delivery and magnetic resonance imaging enhancement. / Park, Huiyul; Yang, Jaemoon; Seo, Sungbaek; Kim, Kyujung; Suh, Jinsuk; Kim, Donghyun; Haam, Seungjoo; Yoo, Kyung Hwa.

In: Small, Vol. 4, No. 2, 01.02.2008, p. 192-196.

Research output: Contribution to journalArticle

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AU - Park, Huiyul

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AU - Kim, Donghyun

AU - Haam, Seungjoo

AU - Yoo, Kyung Hwa

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