Multifunctional nanoparticles for targeted chemophotothermal treatment of cancer cells

Sun Mi Lee; Huiyul Park; Joung Woo Choi; Young Nyun Park; Chae Ok Yun; Kyung-hwa Yoo

doi:10.1002/anie.201101783

Multifunctional nanoparticles for targeted chemophotothermal treatment of cancer cells

Sun Mi Lee, Huiyul Park, Joung Woo Choi, Young Nyun Park, Chae Ok Yun, Kyung-hwa Yoo

Department of Physics

Research output: Contribution to journal › Article

69 Citations (Scopus)

Abstract

Drug and heat delivery to tumors by active targeting with Herceptin-conjugated doxorubicin-loaded poly(ethylene glycol)-poly(lactic-co- glycolic acid)-Au half-shell nanoparticles (HER-DOX-PLGA-Au H-S NPs) is more effective than passive targeting with their HER-free counterparts (DOX-PLGA-Au H-S NPs). Thus, on NIR irradiation, higher intratumoral temperatures were reached in tumor-bearing mice that were treated with the HER-conjugated particles (see picture).

Original language	English
Pages (from-to)	7581-7586
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	33
DOIs	https://doi.org/10.1002/anie.201101783
Publication status	Published - 2011 Aug 8

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All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

Cite this

Lee, S. M., Park, H., Choi, J. W., Park, Y. N., Yun, C. O., & Yoo, K. (2011). Multifunctional nanoparticles for targeted chemophotothermal treatment of cancer cells. Angewandte Chemie - International Edition, 50(33), 7581-7586. https://doi.org/10.1002/anie.201101783

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10.1002/anie.201101783