Multifunctional nanoparticles for targeted chemophotothermal treatment of cancer cells

Sun Mi Lee, Huiyul Park, Joung Woo Choi, Young Nyun Park, Chae Ok Yun, Kyung Hwa Yoo

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

Drug and heat delivery to tumors by active targeting with Herceptin-conjugated doxorubicin-loaded poly(ethylene glycol)-poly(lactic-co- glycolic acid)-Au half-shell nanoparticles (HER-DOX-PLGA-Au H-S NPs) is more effective than passive targeting with their HER-free counterparts (DOX-PLGA-Au H-S NPs). Thus, on NIR irradiation, higher intratumoral temperatures were reached in tumor-bearing mice that were treated with the HER-conjugated particles (see picture).

Original languageEnglish
Pages (from-to)7581-7586
Number of pages6
JournalAngewandte Chemie - International Edition
Volume50
Issue number33
DOIs
Publication statusPublished - 2011 Aug 8

Bibliographical note

Funding Information:
This work has been performed in the framework of the Nuclear Fusion Project of the Kernforschungszentrum Karlsruhe and is supported by the European Fusion Technology Program.

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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