Abstract
Drug and heat delivery to tumors by active targeting with Herceptin-conjugated doxorubicin-loaded poly(ethylene glycol)-poly(lactic-co- glycolic acid)-Au half-shell nanoparticles (HER-DOX-PLGA-Au H-S NPs) is more effective than passive targeting with their HER-free counterparts (DOX-PLGA-Au H-S NPs). Thus, on NIR irradiation, higher intratumoral temperatures were reached in tumor-bearing mice that were treated with the HER-conjugated particles (see picture).
Original language | English |
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Pages (from-to) | 7581-7586 |
Number of pages | 6 |
Journal | Angewandte Chemie - International Edition |
Volume | 50 |
Issue number | 33 |
DOIs | |
Publication status | Published - 2011 Aug 8 |
All Science Journal Classification (ASJC) codes
- Catalysis
- Chemistry(all)