Multifunctional nanoparticles for targeted chemophotothermal treatment of cancer cells

Sun Mi Lee; Huiyul Park; Joung Woo Choi; Young Nyun Park; Chae Ok Yun; Kyung Hwa Yoo

doi:10.1002/anie.201101783

Multifunctional nanoparticles for targeted chemophotothermal treatment of cancer cells

Sun Mi Lee, Huiyul Park, Joung Woo Choi, Young Nyun Park, Chae Ok Yun, Kyung Hwa Yoo

Department of Physics

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

Drug and heat delivery to tumors by active targeting with Herceptin-conjugated doxorubicin-loaded poly(ethylene glycol)-poly(lactic-co- glycolic acid)-Au half-shell nanoparticles (HER-DOX-PLGA-Au H-S NPs) is more effective than passive targeting with their HER-free counterparts (DOX-PLGA-Au H-S NPs). Thus, on NIR irradiation, higher intratumoral temperatures were reached in tumor-bearing mice that were treated with the HER-conjugated particles (see picture).

Original language	English
Pages (from-to)	7581-7586
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	33
DOIs	https://doi.org/10.1002/anie.201101783
Publication status	Published - 2011 Aug 8

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

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abstract = "Drug and heat delivery to tumors by active targeting with Herceptin-conjugated doxorubicin-loaded poly(ethylene glycol)-poly(lactic-co- glycolic acid)-Au half-shell nanoparticles (HER-DOX-PLGA-Au H-S NPs) is more effective than passive targeting with their HER-free counterparts (DOX-PLGA-Au H-S NPs). Thus, on NIR irradiation, higher intratumoral temperatures were reached in tumor-bearing mice that were treated with the HER-conjugated particles (see picture).",

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AU - Yun, Chae Ok

AU - Yoo, Kyung Hwa

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