Multifunctional nanoparticles for targeted chemophotothermal treatment of cancer cells

Sun Mi Lee; Huiyul Park; Joung Woo Choi; Young Nyun Park; Chae Ok Yun; Kyung Hwa Yoo

doi:10.1002/anie.201101783

Multifunctional nanoparticles for targeted chemophotothermal treatment of cancer cells

Sun Mi Lee, Huiyul Park, Joung Woo Choi, Young Nyun Park, Chae Ok Yun, Kyung Hwa Yoo

Department of Physics

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

Drug and heat delivery to tumors by active targeting with Herceptin-conjugated doxorubicin-loaded poly(ethylene glycol)-poly(lactic-co- glycolic acid)-Au half-shell nanoparticles (HER-DOX-PLGA-Au H-S NPs) is more effective than passive targeting with their HER-free counterparts (DOX-PLGA-Au H-S NPs). Thus, on NIR irradiation, higher intratumoral temperatures were reached in tumor-bearing mice that were treated with the HER-conjugated particles (see picture).

Original language	English
Pages (from-to)	7581-7586
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	33
DOIs	https://doi.org/10.1002/anie.201101783
Publication status	Published - 2011 Aug 8

Bibliographical note

Funding Information:
This work has been performed in the framework of the Nuclear Fusion Project of the Kernforschungszentrum Karlsruhe and is supported by the European Fusion Technology Program.

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

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10.1002/anie.201101783

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title = "Multifunctional nanoparticles for targeted chemophotothermal treatment of cancer cells",

abstract = "Drug and heat delivery to tumors by active targeting with Herceptin-conjugated doxorubicin-loaded poly(ethylene glycol)-poly(lactic-co- glycolic acid)-Au half-shell nanoparticles (HER-DOX-PLGA-Au H-S NPs) is more effective than passive targeting with their HER-free counterparts (DOX-PLGA-Au H-S NPs). Thus, on NIR irradiation, higher intratumoral temperatures were reached in tumor-bearing mice that were treated with the HER-conjugated particles (see picture).",

author = "Lee, {Sun Mi} and Huiyul Park and Choi, {Joung Woo} and Park, {Young Nyun} and Yun, {Chae Ok} and Yoo, {Kyung Hwa}",

note = "Funding Information: This work has been performed in the framework of the Nuclear Fusion Project of the Kernforschungszentrum Karlsruhe and is supported by the European Fusion Technology Program.",

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T1 - Multifunctional nanoparticles for targeted chemophotothermal treatment of cancer cells

AU - Lee, Sun Mi

AU - Park, Huiyul

AU - Choi, Joung Woo

AU - Park, Young Nyun

AU - Yun, Chae Ok

AU - Yoo, Kyung Hwa

N1 - Funding Information: This work has been performed in the framework of the Nuclear Fusion Project of the Kernforschungszentrum Karlsruhe and is supported by the European Fusion Technology Program.

PY - 2011/8/8

Y1 - 2011/8/8

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AB - Drug and heat delivery to tumors by active targeting with Herceptin-conjugated doxorubicin-loaded poly(ethylene glycol)-poly(lactic-co- glycolic acid)-Au half-shell nanoparticles (HER-DOX-PLGA-Au H-S NPs) is more effective than passive targeting with their HER-free counterparts (DOX-PLGA-Au H-S NPs). Thus, on NIR irradiation, higher intratumoral temperatures were reached in tumor-bearing mice that were treated with the HER-conjugated particles (see picture).

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Multifunctional nanoparticles for targeted chemophotothermal treatment of cancer cells

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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