Multifunctional nanoparticles for targeted chemophotothermal treatment of cancer cells

Sun Mi Lee, Huiyul Park, Joung Woo Choi, Young Nyun Park, Chae Ok Yun, Kyung-hwa Yoo

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Drug and heat delivery to tumors by active targeting with Herceptin-conjugated doxorubicin-loaded poly(ethylene glycol)-poly(lactic-co- glycolic acid)-Au half-shell nanoparticles (HER-DOX-PLGA-Au H-S NPs) is more effective than passive targeting with their HER-free counterparts (DOX-PLGA-Au H-S NPs). Thus, on NIR irradiation, higher intratumoral temperatures were reached in tumor-bearing mice that were treated with the HER-conjugated particles (see picture).

Original languageEnglish
Pages (from-to)7581-7586
Number of pages6
JournalAngewandte Chemie - International Edition
Volume50
Issue number33
DOIs
Publication statusPublished - 2011 Aug 8

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All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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