Multifunctional proteins in tumorigenesis: Aminoacyl-tRNA synthetases and translational components

Won Lee Sang, Sun Kang Young, Sunghoon Kim

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Since translation is a central process in all living organisms, the components of translational machinery containing aminoacyltRNA synthetases, initiation, elongation, and releasing factors and ribosomal proteins have been considered as housekeepers of the cells. While these components are necessary for translational control, many of them have been found also to be involved in the control of cell fate through the diverse functions that are seemingly unrelated to protein synthesis. Also, there are several lines of evidence, suggesting the association of eukaryotic translational components with cancer development although the exact underlying mechanisms still await further investigation. Here we address the involvement of the translational components in the cell transformation and malignant phenotypes and the relationship of the deregulation of translational control of a wide range of cancers to provide systematic view on the association of translational components with cancers.

Original languageEnglish
Pages (from-to)233-247
Number of pages15
JournalCurrent Proteomics
Volume3
Issue number4
DOIs
Publication statusPublished - 2006 Dec 1

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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