Multifunctional Self-Adhesive Fibrous Layered Matrix (FiLM) for Tissue Glues and Therapeutic Carriers

Ye Eun Yoon, Byung Gee Im, Jung suk Kim, Jae-Hyung Jang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Tissue adhesives, which inherently serve as wound sealants or as hemostatic agents, can be further augmented to acquire crucial functions as scaffolds, thereby accelerating wound healing or elevating the efficacy of tissue regeneration. Herein, multifunctional adherent fibrous matrices, acting as self-adhesive scaffolds capable of cell/gene delivery, were devised by coaxially electrospinning poly(caprolactone) (PCL) and poly(vinylpyrrolidone) (PVP). Wrapping the building block PCL fibers with the adherent PVP layers formed film-like fibrous matrices that could rapidly adhere to wet biological surfaces, referred to as fibrous layered matrix (FiLM) adhesives. The inclusion of ionic salts (i.e., dopamine hydrochloride) in the sheath layers generated spontaneously multilayered fibrous adhesives, whose partial layers could be manually peeled off, termed derivative FiLM (d-FiLM). In the context of scaffolds/tissue adhesives, both FiLM and d-FiLM demonstrated almost identical characteristics (i.e., sticky, mechanical, and performances as cell/gene carriers). Importantly, the single FiLM-process can yield multiple sets of d-FiLM by investing the same processing time, materials, and labor required to form a single conventional adhesive fibrous mat, thereby highlighting the economic aspects of the process. The FiLM/d-FiLM offer highly impacting contributions to many biomedical applications, especially in fields that require urgent aids (e.g., endoscopic surgeries, implantation in wet environments, severe wounds).

Original languageEnglish
Pages (from-to)127-140
Number of pages14
JournalBiomacromolecules
Volume18
Issue number1
DOIs
Publication statusPublished - 2017 Jan 9

Fingerprint

Glues
Adhesives
Tissue
Scaffolds
Tissue Adhesives
Derivatives
Genes
Tissue regeneration
Sealants
Electrospinning
Hemostatics
Surgery
Dopamine
Salts
Personnel
Economics
Fibers
Processing

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Yoon, Ye Eun ; Im, Byung Gee ; Kim, Jung suk ; Jang, Jae-Hyung. / Multifunctional Self-Adhesive Fibrous Layered Matrix (FiLM) for Tissue Glues and Therapeutic Carriers. In: Biomacromolecules. 2017 ; Vol. 18, No. 1. pp. 127-140.
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Multifunctional Self-Adhesive Fibrous Layered Matrix (FiLM) for Tissue Glues and Therapeutic Carriers. / Yoon, Ye Eun; Im, Byung Gee; Kim, Jung suk; Jang, Jae-Hyung.

In: Biomacromolecules, Vol. 18, No. 1, 09.01.2017, p. 127-140.

Research output: Contribution to journalArticle

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