Multilayer fabrication of unobtrusive poly(dimethylsiloxane) nanobrush for tunable cell adhesion

Soo Sang Chae, Joo Hyun Jung, Won Jin Choi, Joung Kyu Park, Hong Koo Baik, Jongjin Jung, Hyuk Wan Ko

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1 Citation (Scopus)


Precise modulation of polymer brush in its thickness and grafting density can cause unexpected cell behaviors and regulated bioactivities. Herein, a nanoscale poly(dimethylsiloxane) (PDMS) brush was employed to use as a controllable material for cell adhesion. Facile fabrication of ultrathin monolayer PDMS nanobrush on an underlying substrate facilitated regaining cell adhesion through long-range cell attractive forces such as the van der Waals forces. We showed that cell adhesion is diminished by increasing the number of nanobrush layers, causing a gradual decrease of the effectiveness of the long-range force. The result demonstrates that ultrathin PDMS nanobrush can either promote or inhibit cell adhesion, which is required for various biomedical fields such as tissue-engineering, anti-fouling coating, and implantable biomaterials and sensors.

Original languageEnglish
Article number1834
JournalScientific reports
Issue number1
Publication statusPublished - 2019 Dec 1

All Science Journal Classification (ASJC) codes

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