Multilayer fabrication of unobtrusive poly(dimethylsiloxane) nanobrush for tunable cell adhesion

Soo Sang Chae, Joo Hyun Jung, Won Jin Choi, Joung Kyu Park, Hong Koo Baik, Jongjin Jung, Hyuk Wan Ko

Research output: Contribution to journalArticle

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Abstract

Precise modulation of polymer brush in its thickness and grafting density can cause unexpected cell behaviors and regulated bioactivities. Herein, a nanoscale poly(dimethylsiloxane) (PDMS) brush was employed to use as a controllable material for cell adhesion. Facile fabrication of ultrathin monolayer PDMS nanobrush on an underlying substrate facilitated regaining cell adhesion through long-range cell attractive forces such as the van der Waals forces. We showed that cell adhesion is diminished by increasing the number of nanobrush layers, causing a gradual decrease of the effectiveness of the long-range force. The result demonstrates that ultrathin PDMS nanobrush can either promote or inhibit cell adhesion, which is required for various biomedical fields such as tissue-engineering, anti-fouling coating, and implantable biomaterials and sensors.

Original languageEnglish
Article number1834
JournalScientific reports
Volume9
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

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Cell Adhesion
Biocompatible Materials
Tissue Engineering
Polymers
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All Science Journal Classification (ASJC) codes

  • General

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Chae, Soo Sang ; Jung, Joo Hyun ; Choi, Won Jin ; Park, Joung Kyu ; Baik, Hong Koo ; Jung, Jongjin ; Ko, Hyuk Wan. / Multilayer fabrication of unobtrusive poly(dimethylsiloxane) nanobrush for tunable cell adhesion. In: Scientific reports. 2019 ; Vol. 9, No. 1.
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Multilayer fabrication of unobtrusive poly(dimethylsiloxane) nanobrush for tunable cell adhesion. / Chae, Soo Sang; Jung, Joo Hyun; Choi, Won Jin; Park, Joung Kyu; Baik, Hong Koo; Jung, Jongjin; Ko, Hyuk Wan.

In: Scientific reports, Vol. 9, No. 1, 1834, 01.12.2019.

Research output: Contribution to journalArticle

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AU - Ko, Hyuk Wan

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