Multimodal label-free detection and discrimination for small molecules using a nanoporous resonator

Jinsung Park, Doyeon Bang, Kuewhan Jang, Eunkyoung Kim, Seungjoo Haam, Sungsoo Na

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

To detect chemical or biological threats, it is crucial that sensor devices can differentiate various target molecules. In general, each different sensing method has its own strengths and weaknesses due to their respective limitations. For example, although resonant sensors have high sensitivity, they are not able to discriminate target molecules. At the same time, although surface-enhanced Raman spectroscopy is a representative label-free detection method that can discriminate target molecules, its fabrication is often complex and expensive. Here we present a label-free multimodal nanoporous resonator-based system for small molecule detection and discrimination that combines the strengths of each of these sensing methods. Our approach is not only able to improve the sensitivity of the resonant sensor but it can also discriminate the target molecules. Furthermore, the fabrication process is swift (lasting <3ǎ €‰min) and convenient.

Original languageEnglish
Article number3456
JournalNature communications
Volume5
DOIs
Publication statusPublished - 2014 Mar 28

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discrimination
Labels
Resonators
resonators
Molecules
molecules
Raman Spectrum Analysis
sensors
Sensors
Fabrication
fabrication
sensitivity
Equipment and Supplies
Raman spectroscopy

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

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abstract = "To detect chemical or biological threats, it is crucial that sensor devices can differentiate various target molecules. In general, each different sensing method has its own strengths and weaknesses due to their respective limitations. For example, although resonant sensors have high sensitivity, they are not able to discriminate target molecules. At the same time, although surface-enhanced Raman spectroscopy is a representative label-free detection method that can discriminate target molecules, its fabrication is often complex and expensive. Here we present a label-free multimodal nanoporous resonator-based system for small molecule detection and discrimination that combines the strengths of each of these sensing methods. Our approach is not only able to improve the sensitivity of the resonant sensor but it can also discriminate the target molecules. Furthermore, the fabrication process is swift (lasting <3ǎ €‰min) and convenient.",
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Multimodal label-free detection and discrimination for small molecules using a nanoporous resonator. / Park, Jinsung; Bang, Doyeon; Jang, Kuewhan; Kim, Eunkyoung; Haam, Seungjoo; Na, Sungsoo.

In: Nature communications, Vol. 5, 3456, 28.03.2014.

Research output: Contribution to journalArticle

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AU - Haam, Seungjoo

AU - Na, Sungsoo

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