Multiple lentigines syndrome: A comparison of normal skin and lentiginous skin by electron microscopy and immunohistochemical staining

Jinn Gill Choi, Sung Nam Chang, SooChan Kim, Wook Hwa Park, Hyuk Jae Kwon

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A 26-year-old Korean man exhibited generalized lentigines, a slight prominence of the chin, short stature, and a familial history consistent with the autosomal dominant mode of inheritance. The multiple lentigines appeared at the age of 1 and spread over his entire body including the scalp, palms, and soles by the age of 4. There were several large dark pigmented spots on the trunk, but no other skin abnormalities were found. We performed histologic studies of the normal skin and the lentigo by both electron and light microscopy with immunohistochemical stains. Routine hematoxylin-eosin staining of the pigmented skin revealed heavily pigmented basal and spinous layers and prominent rete ridges. Fontana-Masson stain showed enormous black pigmentations on the basal and spinous layers of the pigmented macule. S-100 protein stain of the pigmented lesion demonstrated an increased number of melanocytes per unit skin area. Ultrastructural studies showed the presence of extensive aggregated melanosomes within the keratinocytes in the epidermis of lentigo, but not the presence of giant melanosomes in either normal skin or lentigines.

Original languageEnglish
Pages (from-to)400-405
Number of pages6
JournalJournal of Dermatology
Volume25
Issue number6
DOIs
Publication statusPublished - 1998 Jan 1

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LEOPARD Syndrome
Lentigo
Electron Microscopy
Staining and Labeling
Skin
Melanosomes
Coloring Agents
Skin Abnormalities
Chin
S100 Proteins
Melanocytes
Pigmentation
Hematoxylin
Eosine Yellowish-(YS)
Scalp
Keratinocytes
Epidermis
History
Light

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

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title = "Multiple lentigines syndrome: A comparison of normal skin and lentiginous skin by electron microscopy and immunohistochemical staining",
abstract = "A 26-year-old Korean man exhibited generalized lentigines, a slight prominence of the chin, short stature, and a familial history consistent with the autosomal dominant mode of inheritance. The multiple lentigines appeared at the age of 1 and spread over his entire body including the scalp, palms, and soles by the age of 4. There were several large dark pigmented spots on the trunk, but no other skin abnormalities were found. We performed histologic studies of the normal skin and the lentigo by both electron and light microscopy with immunohistochemical stains. Routine hematoxylin-eosin staining of the pigmented skin revealed heavily pigmented basal and spinous layers and prominent rete ridges. Fontana-Masson stain showed enormous black pigmentations on the basal and spinous layers of the pigmented macule. S-100 protein stain of the pigmented lesion demonstrated an increased number of melanocytes per unit skin area. Ultrastructural studies showed the presence of extensive aggregated melanosomes within the keratinocytes in the epidermis of lentigo, but not the presence of giant melanosomes in either normal skin or lentigines.",
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Multiple lentigines syndrome : A comparison of normal skin and lentiginous skin by electron microscopy and immunohistochemical staining. / Choi, Jinn Gill; Chang, Sung Nam; Kim, SooChan; Park, Wook Hwa; Kwon, Hyuk Jae.

In: Journal of Dermatology, Vol. 25, No. 6, 01.01.1998, p. 400-405.

Research output: Contribution to journalArticle

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