Multiple porous synthetic bone graft comprising engineeredmicro-channel for drug carrier and bone regeneration

Chun Sik Bae, Seung Hyun Kim, Taeho Ahn, Yeonji Kim, Se Eun Kim, Seong Soo Kang, Jae Sung Kwon, Kwang Mahn Kim, Sahng Gyoon Kim, Daniel Oh

Research output: Contribution to journalArticlepeer-review

Abstract

Due to high demand but limited supply, there has been an increase in the need to replace autologous bone grafts with alternatives that fulfill osteogenic requirements. In this study, two different types of bone grafts were tested for their drug carrying abilities along with their osteogenic properties. Two different types of alendronate-loaded bone grafts, Bio-Oss (bovine bone graft) and InRoad (biphasic synthetic bone graft) were observed to see how different concentrations of alendronate would affect the sustained release to enhance osteogenesis. In this study, defected ovariectomize-induced osteoporotic rat calvarias were observed for 28 days with three different concentrations of alendronate (0 mg, 1 mg, 5 mg) for both Bio-Oss and InRoad. A higher concentration (5 mg) allowed for a more controlled and sustained release throughout the 28-day comparison to those of lower concentrations (0 mg, 1 mg). When comparing Bio-Oss and InRoad through histology and Micro-CT, InRoad showed higher enhancement in osteogenesis. Through this study, it was observed that alendronate not only brings out robust osteogenesis with InRoad bone grafts, but also enhances bone regeneration in an alendronate-concentration-dependent manner. The combination of higher concentration of alendronate and multiple porous bone graft containing internal micro-channel structure of InRoad resulted in higher osteogenesis with a sustained release of alendronate.

Original languageEnglish
Article number5320
JournalMaterials
Volume14
Issue number18
DOIs
Publication statusPublished - 2021 Sep

Bibliographical note

Funding Information:
This study was partially supported by Chonnam National University, 2016 and J.-S.K., and K.-M.K.; software, Y.K.; validation, S.-H.K., T.A., S.-E.K. and S.-G.K.; investigation, S.-Basic Science Research Program through the National Research Foundation of Korea (NRF) funded H.K., T.A., S.-S.K., S.-E.K., and S.-G.K.; data curation, Y.K.; writing?original draft preparation, D.O. by Ministry of Education (2017R1D1A1B03034829). Compliance with ethical standards. and Y.K.; writing?review and editing, D.O. and C.-S.B.; supervision, D.O. and C.-S.B. All authors.

Publisher Copyright:
© 2021 by the authors.

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics

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