Multiplexed Complementary Signal Transmission for a Self-Regulating Artificial Nervous System

Young Jin Choi, Dong Gue Roe, Yoon Young Choi, Seongchan Kim, Sae Byeok Jo, Hwa Sung Lee, Do Hwan Kim, Jeong Ho Cho

Research output: Contribution to journalArticlepeer-review


Neuromorphic engineering has emerged as a promising research field that can enable efficient and sophisticated signal transmission by mimicking the biological nervous system. This paper presents an artificial nervous system capable of facile self-regulation via multiplexed complementary signals. Based on the tunable nature of the Schottky barrier of a complementary signal integration circuit, a pair of complementary signals is successfully integrated to realize efficient signal transmission. As a proof of concept, a feedback-based blood glucose level control system is constructed by incorporating a glucose/insulin sensor, a complementary signal integration circuit, an artificial synapse, and an artificial neuron circuit. Certain amounts of glucose and insulin in the initial state are detected by each sensor and reflected as positive and negative amplitudes of the multiplexed presynaptic pulses, respectively. Subsequently, the pulses are converted to postsynaptic current, which triggered the injection of glucose or insulin in a way that confined the glucose level to a desirable range. The proposed artificial nervous system demonstrates the notable potential of practical advances in complementary control engineering.

Original languageEnglish
Article number2205155
JournalAdvanced Science
Issue number3
Publication statusPublished - 2023 Jan 25

Bibliographical note

Funding Information:
Y.J.C. and D.G.R. contributed equally this work. This research was supported by Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by Ministry of Science and ICT (NRF‐2019M3D1A1078299) and National R&D Program through the NRF funded by Ministry of Science and ICT (2021M3D1A2049315).

Publisher Copyright:
© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Chemical Engineering(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Engineering(all)
  • Physics and Astronomy(all)


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