Multiplexing natural orientation: Oppositely directed self-assembling peptides

Woo Jin Jeong, Sanghun Han, Hyeseo Park, Kyeong Sik Jin, Yong Beom Lim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We explore here the possibility that polypeptide chains with directional multiplicity might provide for the control of peptide self-assembly processes. We tested this new possibility using an oppositely directed peptide (ODP) supramolecular system. The ODP could make it possible to form a βαβ motif with antiparallel β-sheets, which does not exist in nature. Furthermore, the designed ODPs were able to self-assemble into discrete, homogeneous, and structured protein-like controlled nano-objects. ODPs represent a simple but powerful unnatural self-assembling peptide system that can become a basic scaffold for fabricating more complex and elaborate artificial nanostructures.

Original languageEnglish
Pages (from-to)2138-2145
Number of pages8
JournalBiomacromolecules
Volume15
Issue number6
DOIs
Publication statusPublished - 2014 Jun 9

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Multiplexing natural orientation: Oppositely directed self-assembling peptides'. Together they form a unique fingerprint.

  • Cite this