Abstract
Purpose: This paper presents an overview of multisource inverse-geometry computed tomography (IGCT) as well as the development of a gantry-based research prototype system. The development of the distributed x-ray source is covered in a companion paper [V. B. Neculaes et al., Multisource inverse-geometry CT. Part II. X-ray source design and prototype, Med. Phys. 43, 46174627 (2016)]. While progress updates of this development have been presented at conferences and in journal papers, this paper is the first comprehensive overview of the multisource inverse-geometry CT concept and prototype. The authors also provide a review of all previous IGCT related publications. Methods: The authors designed and implemented a gantry-based 32-source IGCT scanner with 22 cm field-of-view, 16 cm z-coverage, 1 s rotation time, 1.09×1.024 mm detector cell size, as low as 0.4×0.8 mm focal spot size and 80140 kVp x-ray source voltage. The system is built using commercially available CT components and a custom made distributed x-ray source. The authors developed dedicated controls, calibrations, and reconstruction algorithms and evaluated the system performance using phantoms and small animals. Results: The authors performed IGCT system experiments and demonstrated tube current up to 125 mA with up to 32 focal spots. The authors measured a spatial resolution of 13 lp/cm at 5% cutoff. The scatter-to-primary ratio is estimated 62% for a 32 cm water phantom at 140 kVp. The authors scanned several phantoms and small animals. The initial images have relatively high noise due to the low x-ray flux levels but minimal artifacts. Conclusions: IGCT has unique benefits in terms of dose-efficiency and cone-beam artifacts, but comes with challenges in terms of scattered radiation and x-ray flux limits. To the authors knowledge, their prototype is the first gantry-based IGCT scanner. The authors summarized the design and implementation of the scanner and the authors presented results with phantoms and small animals.
| Original language | English |
|---|---|
| Pages (from-to) | 4607-4616 |
| Number of pages | 10 |
| Journal | Medical physics |
| Volume | 43 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2016 Aug 1 |
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All Science Journal Classification (ASJC) codes
- Biophysics
- Radiology Nuclear Medicine and imaging
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}
Multisource inverse-geometry CT. Part I. System concept and development. / De Man, Bruno; Uribe, Jorge; Baek, Jongduk; Harrison, Dan; Yin, Zhye; Longtin, Randy; Roy, Jaydeep; Waters, Bill; Wilson, Colin; Short, Jonathan; Inzinna, Lou; Reynolds, Joseph; Neculaes, V. Bogdan; Frutschy, Kristopher; Senzig, Bob; Pelc, Norbert.
In: Medical physics, Vol. 43, No. 8, 01.08.2016, p. 4607-4616.Research output: Contribution to journal › Article
TY - JOUR
T1 - Multisource inverse-geometry CT. Part I. System concept and development
AU - De Man, Bruno
AU - Uribe, Jorge
AU - Baek, Jongduk
AU - Harrison, Dan
AU - Yin, Zhye
AU - Longtin, Randy
AU - Roy, Jaydeep
AU - Waters, Bill
AU - Wilson, Colin
AU - Short, Jonathan
AU - Inzinna, Lou
AU - Reynolds, Joseph
AU - Neculaes, V. Bogdan
AU - Frutschy, Kristopher
AU - Senzig, Bob
AU - Pelc, Norbert
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Purpose: This paper presents an overview of multisource inverse-geometry computed tomography (IGCT) as well as the development of a gantry-based research prototype system. The development of the distributed x-ray source is covered in a companion paper [V. B. Neculaes et al., Multisource inverse-geometry CT. Part II. X-ray source design and prototype, Med. Phys. 43, 46174627 (2016)]. While progress updates of this development have been presented at conferences and in journal papers, this paper is the first comprehensive overview of the multisource inverse-geometry CT concept and prototype. The authors also provide a review of all previous IGCT related publications. Methods: The authors designed and implemented a gantry-based 32-source IGCT scanner with 22 cm field-of-view, 16 cm z-coverage, 1 s rotation time, 1.09×1.024 mm detector cell size, as low as 0.4×0.8 mm focal spot size and 80140 kVp x-ray source voltage. The system is built using commercially available CT components and a custom made distributed x-ray source. The authors developed dedicated controls, calibrations, and reconstruction algorithms and evaluated the system performance using phantoms and small animals. Results: The authors performed IGCT system experiments and demonstrated tube current up to 125 mA with up to 32 focal spots. The authors measured a spatial resolution of 13 lp/cm at 5% cutoff. The scatter-to-primary ratio is estimated 62% for a 32 cm water phantom at 140 kVp. The authors scanned several phantoms and small animals. The initial images have relatively high noise due to the low x-ray flux levels but minimal artifacts. Conclusions: IGCT has unique benefits in terms of dose-efficiency and cone-beam artifacts, but comes with challenges in terms of scattered radiation and x-ray flux limits. To the authors knowledge, their prototype is the first gantry-based IGCT scanner. The authors summarized the design and implementation of the scanner and the authors presented results with phantoms and small animals.
AB - Purpose: This paper presents an overview of multisource inverse-geometry computed tomography (IGCT) as well as the development of a gantry-based research prototype system. The development of the distributed x-ray source is covered in a companion paper [V. B. Neculaes et al., Multisource inverse-geometry CT. Part II. X-ray source design and prototype, Med. Phys. 43, 46174627 (2016)]. While progress updates of this development have been presented at conferences and in journal papers, this paper is the first comprehensive overview of the multisource inverse-geometry CT concept and prototype. The authors also provide a review of all previous IGCT related publications. Methods: The authors designed and implemented a gantry-based 32-source IGCT scanner with 22 cm field-of-view, 16 cm z-coverage, 1 s rotation time, 1.09×1.024 mm detector cell size, as low as 0.4×0.8 mm focal spot size and 80140 kVp x-ray source voltage. The system is built using commercially available CT components and a custom made distributed x-ray source. The authors developed dedicated controls, calibrations, and reconstruction algorithms and evaluated the system performance using phantoms and small animals. Results: The authors performed IGCT system experiments and demonstrated tube current up to 125 mA with up to 32 focal spots. The authors measured a spatial resolution of 13 lp/cm at 5% cutoff. The scatter-to-primary ratio is estimated 62% for a 32 cm water phantom at 140 kVp. The authors scanned several phantoms and small animals. The initial images have relatively high noise due to the low x-ray flux levels but minimal artifacts. Conclusions: IGCT has unique benefits in terms of dose-efficiency and cone-beam artifacts, but comes with challenges in terms of scattered radiation and x-ray flux limits. To the authors knowledge, their prototype is the first gantry-based IGCT scanner. The authors summarized the design and implementation of the scanner and the authors presented results with phantoms and small animals.
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UR - http://www.scopus.com/inward/citedby.url?scp=84978972845&partnerID=8YFLogxK
U2 - 10.1118/1.4954846
DO - 10.1118/1.4954846
M3 - Article
C2 - 27487877
AN - SCOPUS:84978972845
VL - 43
SP - 4607
EP - 4616
JO - Medical Physics
JF - Medical Physics
SN - 0094-2405
IS - 8
ER -