Recognition of glycans by proteins plays a crucial role in a variety of physiological processes in cells and living organisms. In addition, interactions of glycans with proteins are involved in the development of diverse diseases, such as pathogen infection, inflammation and tumor metastasis. It is well-known that multivalent glycans bind to proteins much more strongly than do their monomeric counterparts. Owing to this property, numerous multivalent glycans have been utilized to elucidate glycan-mediated biological processes and to discover glycan-based biomedical agents. In this review, we discuss recent advances (2014-2020) made in the development and biological and biomedical applications of synthetic multivalent glycans, including neoglycopeptides, neoglycoproteins, glycodendrimers, glycopolymers, glyconanoparticles and glycoliposomes. We hope this review assists researchers in the design and development of novel multivalent glycans with predictable activities.
|Number of pages||27|
|Journal||Chemical Society reviews|
|Publication status||Published - 2021 Sept 21|
Bibliographical noteFunding Information:
This study was supported financially by the National Research Foundation of Korea (grant no. 2020R1A2C3003462 to I. S.) and the KRICT (grant no. SI-2131-40 and SI-2161-135 to J. Y. H.).
© The Royal Society of Chemistry.
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