Muscle characteristics obtained using computed tomography as prognosticators in patients with castration-resistant prostate cancer

Jongsoo Lee, Jee Soo Park, Ji Eun Heo, Hyun Kyu Ahn, Won Sik Jang, Won Sik Ham, Koon Ho Rha, Young Deuk Choi

Research output: Contribution to journalArticle

Abstract

Limited studies have investigated the correlation between body composition and prostate cancer outcomes. We analyzed the effect of muscle mass and quality on castration-resistant prostate cancer (CRPC) outcomes. Skeletal muscle index (SMI) and skeletal muscle attenuation (SMA) were measured for 411 patients at the L3 vertebral level using computed tomography at CRPC diagnosis and were dived to low and high groups at the value of median. Analysis of the skeletal phenotypes and age (<70 and >70 years) was performed to evaluate the effect of SMI and SMA. The median survival rates for patients with low and high SMI were 19 and 24 months (p = 0.015), and those with low and high SMAs were 15 and 26 months (p < 0.001), respectively. In the subgroup analysis by age, SMA was a significant prognosticator in both groups, while SMI was a significant prognosticator only in patients aged >70 years. Patients with low SMA + low SMI had the worst prognosis. Muscle characteristics seems to be a prognosticator in survival of CRPC patients and may be considered in treatment planning.

Original languageEnglish
Article number1864
Pages (from-to)1-13
Number of pages13
JournalCancers
Volume12
Issue number7
DOIs
Publication statusPublished - 2020 Jul

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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