Mushroom consumption and risk of total and site-specific cancer in two large U.S. prospective cohorts

Dong Hoon Lee; Meng Yang; Nana Keum; Edward L. Giovannucci; Qi Sun; Jorge E. Chavarro

doi:10.1158/1940-6207.CAPR-19-0101

Mushroom consumption and risk of total and site-specific cancer in two large U.S. prospective cohorts

Dong Hoon Lee, Meng Yang, Nana Keum, Edward L. Giovannucci, Qi Sun, Jorge E. Chavarro

Department of Sports Industry Studies

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Abstract

Several case-control studies have reported that mushroom consumption may be associated with reduced risk of certain cancers. However, epidemiologic studies have not yet prospectively examined the association of mushroom consumption with total and various site-specific cancer risks. This prospective cohort study included 68, 327 women (Nurses' Health Study, 1986-2012) and 44, 664 men (Health Professionals Follow-up Study, 1986-2012) who were free of cancer at baseline. Mushroom consumption was assessed at baseline using a validated food frequency questionnaire. Covariates were assessed using biennial questionnaires during the follow-up. We used Cox proportional hazards models to estimate hazard ratios (HR) and 95%confidence intervals (CI) of total and 17 site-specific cancers associated with mushroom consumption. During up to 26 years of follow-up, we documented 22, 469 incident cancer cases (15, 103 in women and 7, 366 in men). In the pooled multivariable analysis, participants who consumed five or more servings of mushrooms per week had no significantly different risk of total cancer (HR, 1.06; 95% CI, 0.98-1.14) than participants who almost never consumed mushrooms. We consistently found no association between mushroom consumption and risk of 16 site-specific cancers. However, there was a marginal positive association between mushroom consumption and risk of lung cancer (Pt_rend =0.05). In conclusion, we found no association between mushroom consumption and total and site-specific cancers in U.S. women and men. More prospective cohort studies are needed to examine the associations for specific cancer types in diverse racial/ ethnic groups.

Original language	English
Pages (from-to)	517-525
Number of pages	9
Journal	Cancer Prevention Research
Volume	12
Issue number	8
DOIs	https://doi.org/10.1158/1940-6207.CAPR-19-0101
Publication status	Published - 2019

Bibliographical note

Funding Information:
We thank the participants and staff of the NHS and HPFS for their valuable contributions, as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, and WY. The authors assume full responsibility for analyses and interpretation of these data. This work was supported by grants from the NIH (UM1 CA186107, UM1 CA167552, and P01 CA87969) and a grant from Horticulture Australia Limited. N. Keum was supported by funding from the National Research Foundation of Korea (NRF-2018R1A4A1022589).

Publisher Copyright:
© 2019 American Association for Cancer Research.

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/1940-6207.CAPR-19-0101

Cite this

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title = "Mushroom consumption and risk of total and site-specific cancer in two large U.S. prospective cohorts",

abstract = "Several case-control studies have reported that mushroom consumption may be associated with reduced risk of certain cancers. However, epidemiologic studies have not yet prospectively examined the association of mushroom consumption with total and various site-specific cancer risks. This prospective cohort study included 68, 327 women (Nurses' Health Study, 1986-2012) and 44, 664 men (Health Professionals Follow-up Study, 1986-2012) who were free of cancer at baseline. Mushroom consumption was assessed at baseline using a validated food frequency questionnaire. Covariates were assessed using biennial questionnaires during the follow-up. We used Cox proportional hazards models to estimate hazard ratios (HR) and 95%confidence intervals (CI) of total and 17 site-specific cancers associated with mushroom consumption. During up to 26 years of follow-up, we documented 22, 469 incident cancer cases (15, 103 in women and 7, 366 in men). In the pooled multivariable analysis, participants who consumed five or more servings of mushrooms per week had no significantly different risk of total cancer (HR, 1.06; 95% CI, 0.98-1.14) than participants who almost never consumed mushrooms. We consistently found no association between mushroom consumption and risk of 16 site-specific cancers. However, there was a marginal positive association between mushroom consumption and risk of lung cancer (Ptrend =0.05). In conclusion, we found no association between mushroom consumption and total and site-specific cancers in U.S. women and men. More prospective cohort studies are needed to examine the associations for specific cancer types in diverse racial/ ethnic groups.",

author = "Lee, {Dong Hoon} and Meng Yang and Nana Keum and Giovannucci, {Edward L.} and Qi Sun and Chavarro, {Jorge E.}",

note = "Funding Information: We thank the participants and staff of the NHS and HPFS for their valuable contributions, as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, and WY. The authors assume full responsibility for analyses and interpretation of these data. This work was supported by grants from the NIH (UM1 CA186107, UM1 CA167552, and P01 CA87969) and a grant from Horticulture Australia Limited. N. Keum was supported by funding from the National Research Foundation of Korea (NRF-2018R1A4A1022589). Publisher Copyright: {\textcopyright} 2019 American Association for Cancer Research.",

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doi = "10.1158/1940-6207.CAPR-19-0101",

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AU - Sun, Qi

AU - Chavarro, Jorge E.

N1 - Funding Information: We thank the participants and staff of the NHS and HPFS for their valuable contributions, as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, and WY. The authors assume full responsibility for analyses and interpretation of these data. This work was supported by grants from the NIH (UM1 CA186107, UM1 CA167552, and P01 CA87969) and a grant from Horticulture Australia Limited. N. Keum was supported by funding from the National Research Foundation of Korea (NRF-2018R1A4A1022589). Publisher Copyright: © 2019 American Association for Cancer Research.

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N2 - Several case-control studies have reported that mushroom consumption may be associated with reduced risk of certain cancers. However, epidemiologic studies have not yet prospectively examined the association of mushroom consumption with total and various site-specific cancer risks. This prospective cohort study included 68, 327 women (Nurses' Health Study, 1986-2012) and 44, 664 men (Health Professionals Follow-up Study, 1986-2012) who were free of cancer at baseline. Mushroom consumption was assessed at baseline using a validated food frequency questionnaire. Covariates were assessed using biennial questionnaires during the follow-up. We used Cox proportional hazards models to estimate hazard ratios (HR) and 95%confidence intervals (CI) of total and 17 site-specific cancers associated with mushroom consumption. During up to 26 years of follow-up, we documented 22, 469 incident cancer cases (15, 103 in women and 7, 366 in men). In the pooled multivariable analysis, participants who consumed five or more servings of mushrooms per week had no significantly different risk of total cancer (HR, 1.06; 95% CI, 0.98-1.14) than participants who almost never consumed mushrooms. We consistently found no association between mushroom consumption and risk of 16 site-specific cancers. However, there was a marginal positive association between mushroom consumption and risk of lung cancer (Ptrend =0.05). In conclusion, we found no association between mushroom consumption and total and site-specific cancers in U.S. women and men. More prospective cohort studies are needed to examine the associations for specific cancer types in diverse racial/ ethnic groups.

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Mushroom consumption and risk of total and site-specific cancer in two large U.S. prospective cohorts

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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