MuSK antibody-positive, seronegative myasthenia gravis in Korea

Jee Young Lee, Jung Joon Sung, Joong Yang Cho, Dong Hoon Oh, Hyun Jung Kim, Jong Ha Park, Kwang Woo Lee, Young Chul Choi, Angela Vincent

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Abstract

Several reports from Western countries suggest differences in the clinical features of patients with muscle specific kinase (MuSK) antibody-positive and -negative seronegative myasthenia gravis (MG). We performed the first survey in Korea of MuSK antibodies, studying 23 patients with acetylcholine receptor (AChR)-antibody seronegative MG. MuSK antibodies were present in 4 (26.7%) of 15 generalized seronegative MG patients and none of 8 ocular seronegative MG patients. All four MuSK positive patients were females, with pharyngeal and respiratory muscle weakness, and required immunosuppressive treatment. However, overall disease severity and age at onset was similar to that of MuSK-negative MG and treatment responses were equally good.

Original languageEnglish
Pages (from-to)353-355
Number of pages3
JournalJournal of Clinical Neuroscience
Volume13
Issue number3
DOIs
Publication statusPublished - 2006 Apr

All Science Journal Classification (ASJC) codes

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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    Lee, J. Y., Sung, J. J., Cho, J. Y., Oh, D. H., Kim, H. J., Park, J. H., Lee, K. W., Choi, Y. C., & Vincent, A. (2006). MuSK antibody-positive, seronegative myasthenia gravis in Korea. Journal of Clinical Neuroscience, 13(3), 353-355. https://doi.org/10.1016/j.jocn.2005.04.028