Mutational analysis of influenza B virus RNA transcription in vitro

Yeon Sook Lee, Baik L. Seong

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The roles of the 3'- and 5'-terminal nucleotides and the panhandle structure of influenza B virus virion RNA were analyzed in vitro by transcription of model RNA templates with influenza B virus RNA polymerase. The results suggest that the stability of the panhandle and breathing of the extreme ends of the panhandle are important factors for efficient transcription. Influenza B virus polymerase appears to be more tolerant of mutations in the panhandle structure than influenza A virus polymerase. This is consistent with the greater degree of heterogeneity observed naturally in the 3'-terminal nucleotides of the virion RNA of influenza B virus than in influenza A virus.

Original languageEnglish
Pages (from-to)1232-1236
Number of pages5
JournalJournal of Virology
Volume70
Issue number2
DOIs
Publication statusPublished - 1996

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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