Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit

Yeon Hee Ban, Jong Hyun Lee, Gyo Rim Gu, Boram Lee, Sangjoon Mo, Ho Jeong Kwon, Yeo Joon Yoon

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A FK506 analogue containing a non-natural starter unit was obtained through mutasynthesis by feeding cultures of Streptomyces sp. KCTC 11604BP fkbO deletion mutant with 3-cyclohexene-1-carboxylic acid. The structure of the new compound, 32-dehydroxy-FK506, and its biological activities were determined.

Original languageEnglish
Pages (from-to)944-947
Number of pages4
JournalMolecular BioSystems
Volume9
Issue number5
DOIs
Publication statusPublished - 2013 May 1

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Molecular Biology

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