Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates

Su Young Kim, Byung Woo Jhun, Seong Mi Moon, Sun Hye Shin, Kyeongman Jeon, O. Jung Kwon, In Young Yoo, Hee Jae Huh, Chang Seok Ki, Nam Yong Lee, Sung Jae Shin, Charles L. Daley, Gee Young Suh, Won Jung Koh

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Abstract

Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.

Original languageEnglish
Article numbere00527-18
JournalAntimicrobial agents and chemotherapy
Volume62
Issue number9
DOIs
Publication statusPublished - 2018 Sep

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Kim, S. Y., Jhun, B. W., Moon, S. M., Shin, S. H., Jeon, K., Jung Kwon, O., Yoo, I. Y., Huh, H. J., Ki, C. S., Lee, N. Y., Shin, S. J., Daley, C. L., Suh, G. Y., & Koh, W. J. (2018). Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates. Antimicrobial agents and chemotherapy, 62(9), [e00527-18]. https://doi.org/10.1128/AAC.00527-18