Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.
Bibliographical noteFunding Information:
This work was supported by the Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education (grant NRF-2016R1A6A3A11930364), and Samsung Medical Center (grant CRP1500029).
C.L.D. has received grants from Insmed, Inc., not associated with this work. Otherwise, we have no conflicts of interest to declare.
All Science Journal Classification (ASJC) codes
- Pharmacology (medical)
- Infectious Diseases