Abstract
Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.
| Original language | English |
|---|---|
| Article number | e00527-18 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 62 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2018 Sep 1 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
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Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates. / Kim, Su Young; Jhun, Byung Woo; Moon, Seong Mi; Shin, Sun Hye; Jeon, Kyeongman; Jung Kwon, O.; Yoo, In Young; Huh, Hee Jae; Ki, Chang Seok; Lee, Nam Yong; Shin, SungJae; Daley, Charles L.; Suh, Gee Young; Koh, Won Jung.
In: Antimicrobial agents and chemotherapy, Vol. 62, No. 9, e00527-18, 01.09.2018.Research output: Contribution to journal › Article
TY - JOUR
T1 - Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates
AU - Kim, Su Young
AU - Jhun, Byung Woo
AU - Moon, Seong Mi
AU - Shin, Sun Hye
AU - Jeon, Kyeongman
AU - Jung Kwon, O.
AU - Yoo, In Young
AU - Huh, Hee Jae
AU - Ki, Chang Seok
AU - Lee, Nam Yong
AU - Shin, SungJae
AU - Daley, Charles L.
AU - Suh, Gee Young
AU - Koh, Won Jung
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.
AB - Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.
UR - http://www.scopus.com/inward/record.url?scp=85052236237&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052236237&partnerID=8YFLogxK
U2 - 10.1128/AAC.00527-18
DO - 10.1128/AAC.00527-18
M3 - Article
VL - 62
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 9
M1 - e00527-18
ER -