Abstract
Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.
Original language | English |
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Article number | e00527-18 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 62 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2018 Sep |
Bibliographical note
Funding Information:This work was supported by the Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education (grant NRF-2016R1A6A3A11930364), and Samsung Medical Center (grant CRP1500029).
Funding Information:
C.L.D. has received grants from Insmed, Inc., not associated with this work. Otherwise, we have no conflicts of interest to declare.
Publisher Copyright:
Copyright © 2018 American Society for Microbiology. All Rights Reserved.
All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases