Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates

Su Young Kim, Byung Woo Jhun, Seong Mi Moon, Sun Hye Shin, Kyeongman Jeon, O. Jung Kwon, In Young Yoo, Hee Jae Huh, Chang Seok Ki, Nam Yong Lee, SungJae Shin, Charles L. Daley, Gee Young Suh, Won Jung Koh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.

Original languageEnglish
Article numbere00527-18
JournalAntimicrobial agents and chemotherapy
Volume62
Issue number9
DOIs
Publication statusPublished - 2018 Sep 1

Fingerprint

Mycobacterium avium Complex
Mycobacterium
Mutation
Fluoroquinolones
moxifloxacin

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Kim, Su Young ; Jhun, Byung Woo ; Moon, Seong Mi ; Shin, Sun Hye ; Jeon, Kyeongman ; Jung Kwon, O. ; Yoo, In Young ; Huh, Hee Jae ; Ki, Chang Seok ; Lee, Nam Yong ; Shin, SungJae ; Daley, Charles L. ; Suh, Gee Young ; Koh, Won Jung. / Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates. In: Antimicrobial agents and chemotherapy. 2018 ; Vol. 62, No. 9.
@article{cbb75023316e4da6856a54f1fd8deae2,
title = "Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates",
abstract = "Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.",
author = "Kim, {Su Young} and Jhun, {Byung Woo} and Moon, {Seong Mi} and Shin, {Sun Hye} and Kyeongman Jeon and {Jung Kwon}, O. and Yoo, {In Young} and Huh, {Hee Jae} and Ki, {Chang Seok} and Lee, {Nam Yong} and SungJae Shin and Daley, {Charles L.} and Suh, {Gee Young} and Koh, {Won Jung}",
year = "2018",
month = "9",
day = "1",
doi = "10.1128/AAC.00527-18",
language = "English",
volume = "62",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "9",

}

Kim, SY, Jhun, BW, Moon, SM, Shin, SH, Jeon, K, Jung Kwon, O, Yoo, IY, Huh, HJ, Ki, CS, Lee, NY, Shin, S, Daley, CL, Suh, GY & Koh, WJ 2018, 'Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates', Antimicrobial agents and chemotherapy, vol. 62, no. 9, e00527-18. https://doi.org/10.1128/AAC.00527-18

Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates. / Kim, Su Young; Jhun, Byung Woo; Moon, Seong Mi; Shin, Sun Hye; Jeon, Kyeongman; Jung Kwon, O.; Yoo, In Young; Huh, Hee Jae; Ki, Chang Seok; Lee, Nam Yong; Shin, SungJae; Daley, Charles L.; Suh, Gee Young; Koh, Won Jung.

In: Antimicrobial agents and chemotherapy, Vol. 62, No. 9, e00527-18, 01.09.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates

AU - Kim, Su Young

AU - Jhun, Byung Woo

AU - Moon, Seong Mi

AU - Shin, Sun Hye

AU - Jeon, Kyeongman

AU - Jung Kwon, O.

AU - Yoo, In Young

AU - Huh, Hee Jae

AU - Ki, Chang Seok

AU - Lee, Nam Yong

AU - Shin, SungJae

AU - Daley, Charles L.

AU - Suh, Gee Young

AU - Koh, Won Jung

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.

AB - Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.

UR - http://www.scopus.com/inward/record.url?scp=85052236237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052236237&partnerID=8YFLogxK

U2 - 10.1128/AAC.00527-18

DO - 10.1128/AAC.00527-18

M3 - Article

VL - 62

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 9

M1 - e00527-18

ER -