Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates

Su Young Kim; Byung Woo Jhun; Seong Mi Moon; Sun Hye Shin; Kyeongman Jeon; O. Jung Kwon; In Young Yoo; Hee Jae Huh; Chang Seok Ki; Nam Yong Lee; Sung Jae Shin; Charles L. Daley; Gee Young Suh; Won Jung Koh

doi:10.1128/AAC.00527-18

Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates

Su Young Kim, Byung Woo Jhun, Seong Mi Moon, Sun Hye Shin, Kyeongman Jeon, O. Jung Kwon, In Young Yoo, Hee Jae Huh, Chang Seok Ki, Nam Yong Lee, Sung Jae Shin, Charles L. Daley, Gee Young Suh, Won Jung Koh

Department of Microbiology

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.

Original language	English
Article number	e00527-18
Journal	Antimicrobial agents and chemotherapy
Volume	62
Issue number	9
DOIs	https://doi.org/10.1128/AAC.00527-18
Publication status	Published - 2018 Sep

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education (grant NRF-2016R1A6A3A11930364), and Samsung Medical Center (grant CRP1500029).

Funding Information:
C.L.D. has received grants from Insmed, Inc., not associated with this work. Otherwise, we have no conflicts of interest to declare.

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Kim, S. Y., Jhun, B. W., Moon, S. M., Shin, S. H., Jeon, K., Jung Kwon, O., Yoo, I. Y., Huh, H. J., Ki, C. S., Lee, N. Y., Shin, S. J., Daley, C. L., Suh, G. Y., & Koh, W. J. (2018). Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates. Antimicrobial agents and chemotherapy, 62(9), [e00527-18]. https://doi.org/10.1128/AAC.00527-18

Kim, Su Young ; Jhun, Byung Woo ; Moon, Seong Mi ; Shin, Sun Hye ; Jeon, Kyeongman ; Jung Kwon, O. ; Yoo, In Young ; Huh, Hee Jae ; Ki, Chang Seok ; Lee, Nam Yong ; Shin, Sung Jae ; Daley, Charles L. ; Suh, Gee Young ; Koh, Won Jung. / Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates. In: Antimicrobial agents and chemotherapy. 2018 ; Vol. 62, No. 9.

@article{cbb75023316e4da6856a54f1fd8deae2,

title = "Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates",

abstract = "Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.",

author = "Kim, {Su Young} and Jhun, {Byung Woo} and Moon, {Seong Mi} and Shin, {Sun Hye} and Kyeongman Jeon and {Jung Kwon}, O. and Yoo, {In Young} and Huh, {Hee Jae} and Ki, {Chang Seok} and Lee, {Nam Yong} and Shin, {Sung Jae} and Daley, {Charles L.} and Suh, {Gee Young} and Koh, {Won Jung}",

note = "Funding Information: This work was supported by the Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education (grant NRF-2016R1A6A3A11930364), and Samsung Medical Center (grant CRP1500029). Funding Information: C.L.D. has received grants from Insmed, Inc., not associated with this work. Otherwise, we have no conflicts of interest to declare.",

year = "2018",

month = sep,

doi = "10.1128/AAC.00527-18",

language = "English",

volume = "62",

journal = "Antimicrobial Agents and Chemotherapy",

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Kim, SY, Jhun, BW, Moon, SM, Shin, SH, Jeon, K, Jung Kwon, O, Yoo, IY, Huh, HJ, Ki, CS, Lee, NY, Shin, SJ, Daley, CL, Suh, GY & Koh, WJ 2018, 'Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates', Antimicrobial agents and chemotherapy, vol. 62, no. 9, e00527-18. https://doi.org/10.1128/AAC.00527-18

Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates. / Kim, Su Young; Jhun, Byung Woo; Moon, Seong Mi; Shin, Sun Hye; Jeon, Kyeongman; Jung Kwon, O.; Yoo, In Young; Huh, Hee Jae; Ki, Chang Seok; Lee, Nam Yong; Shin, Sung Jae; Daley, Charles L.; Suh, Gee Young; Koh, Won Jung.

In: Antimicrobial agents and chemotherapy, Vol. 62, No. 9, e00527-18, 09.2018.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates

AU - Kim, Su Young

AU - Jhun, Byung Woo

AU - Moon, Seong Mi

AU - Shin, Sun Hye

AU - Jeon, Kyeongman

AU - Jung Kwon, O.

AU - Yoo, In Young

AU - Huh, Hee Jae

AU - Ki, Chang Seok

AU - Lee, Nam Yong

AU - Shin, Sung Jae

AU - Daley, Charles L.

AU - Suh, Gee Young

AU - Koh, Won Jung

N1 - Funding Information: This work was supported by the Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education (grant NRF-2016R1A6A3A11930364), and Samsung Medical Center (grant CRP1500029). Funding Information: C.L.D. has received grants from Insmed, Inc., not associated with this work. Otherwise, we have no conflicts of interest to declare.

PY - 2018/9

Y1 - 2018/9

N2 - Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.

AB - Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.

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