Abstract
Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.
| Original language | English |
|---|---|
| Article number | e00527-18 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 62 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2018 Sep |
All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
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Kim, S. Y., Jhun, B. W., Moon, S. M., Shin, S. H., Jeon, K., Jung Kwon, O., Yoo, I. Y., Huh, H. J., Ki, C. S., Lee, N. Y., Shin, S. J., Daley, C. L., Suh, G. Y., & Koh, W. J. (2018). Mutations in gyrA and gyrB in moxifloxacin-resistant mycobacterium avium complex and mycobacterium abscessus complex clinical isolates. Antimicrobial agents and chemotherapy, 62(9), [e00527-18]. https://doi.org/10.1128/AAC.00527-18