Mutations in isocitrate dehydrogenase isoforms 1 and 2 are rare events in primary central nervous system and non-central nervous system diffuse large B cell lymphoma

Songmi Noh, Eun Ju Park, Junjeong Choi, Sarah Lee, Seon Jung Jang, Se Hoon Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background and aim: Mutations in isocitrate dehydrogenase enzyme isoforms 1 (IDH1) and 2 (IDH2) have been identified in many cancers, including gliomas and acute myeloid leukemia. The aim of this study was to determine whether these genes are mutated in the primary central nervous system lymphoma (PCNSL). Methods: We analyzed IDH1 and IDH2 mutations in 20 PCNSL and 30 non-central nervous system (CNS) diffuse large B-cell lymphomas (DLBCLs) using routine formalin-fixed paraffin-embedded tissues and a polymerase chain reaction assay focusing on the known mutation hot spots, Arg 132 of IDH1 and Arg 172 of IDH2. Results: We did not detect mutations in IDH1 or IDH2 in PCNSL nor non-CNS DLBCL. Conclusions: Although IDH1 and IDH2 mutations are known to be important in gliomas and in some hematologic malignancies, they appear to be very rare events in PCNS and non-CNS DLBCLs. Further studies on other IDH mutations in larger, non-CNS DLBCL populations are needed.

Original languageEnglish
Pages (from-to)58-62
Number of pages5
JournalBasic and Applied Pathology
Volume4
Issue number2
DOIs
Publication statusPublished - 2011 Jun 1

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Isocitrate Dehydrogenase
Lymphoma, Large B-Cell, Diffuse
Nervous System
Protein Isoforms
Central Nervous System
Mutation
Enzymes
Lymphoma
Glioma
Hematologic Neoplasms
Acute Myeloid Leukemia
Paraffin
Formaldehyde
Polymerase Chain Reaction
Population
Genes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

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title = "Mutations in isocitrate dehydrogenase isoforms 1 and 2 are rare events in primary central nervous system and non-central nervous system diffuse large B cell lymphoma",
abstract = "Background and aim: Mutations in isocitrate dehydrogenase enzyme isoforms 1 (IDH1) and 2 (IDH2) have been identified in many cancers, including gliomas and acute myeloid leukemia. The aim of this study was to determine whether these genes are mutated in the primary central nervous system lymphoma (PCNSL). Methods: We analyzed IDH1 and IDH2 mutations in 20 PCNSL and 30 non-central nervous system (CNS) diffuse large B-cell lymphomas (DLBCLs) using routine formalin-fixed paraffin-embedded tissues and a polymerase chain reaction assay focusing on the known mutation hot spots, Arg 132 of IDH1 and Arg 172 of IDH2. Results: We did not detect mutations in IDH1 or IDH2 in PCNSL nor non-CNS DLBCL. Conclusions: Although IDH1 and IDH2 mutations are known to be important in gliomas and in some hematologic malignancies, they appear to be very rare events in PCNS and non-CNS DLBCLs. Further studies on other IDH mutations in larger, non-CNS DLBCL populations are needed.",
author = "Songmi Noh and Park, {Eun Ju} and Junjeong Choi and Sarah Lee and Jang, {Seon Jung} and Kim, {Se Hoon}",
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Mutations in isocitrate dehydrogenase isoforms 1 and 2 are rare events in primary central nervous system and non-central nervous system diffuse large B cell lymphoma. / Noh, Songmi; Park, Eun Ju; Choi, Junjeong; Lee, Sarah; Jang, Seon Jung; Kim, Se Hoon.

In: Basic and Applied Pathology, Vol. 4, No. 2, 01.06.2011, p. 58-62.

Research output: Contribution to journalArticle

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AU - Jang, Seon Jung

AU - Kim, Se Hoon

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