Muurolane-type sesquiterpenes from marine sponge Dysidea cinerea

Phan Van Kiem; Chau Van Minh; Nguyen Xuan Nhiem; Nguyen Thi Cuc; Ngo Van Quang; Hoang Le Tuan Anh; Bui Huu Tai; Pham Hai Yen; Nguyen Thi Hoai; Kim Young Ho; Nanyoung Kim; Seon Ju Park; Seung Hyun Kim

doi:10.1002/mrc.4030

Muurolane-type sesquiterpenes from marine sponge Dysidea cinerea

Phan Van Kiem, Chau Van Minh, Nguyen Xuan Nhiem, Nguyen Thi Cuc, Ngo Van Quang, Hoang Le Tuan Anh, Bui Huu Tai, Pham Hai Yen, Nguyen Thi Hoai, Kim Young Ho, Nanyoung Kim, Seon Ju Park, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Seven new muurolane-type sesquiterpenes, (4R,5R)-muurol-1(6),10(14)-diene- 4,5-diol (1), (4R,5R)-muurol-1(6)-ene-4,5-diol (2), (4R,5R,10R)-10- methoxymuurol-1(6)-ene-4,5-diol (3), (4S)-4-hydroxy-1,10-seco-muurol-5-ene-1,10- dione (4), (4R)-4-hydroxy- 1,10-seco-muurol-5-ene-1,10-dione (5), (6S,10S)-6,10-dihydroxy-7,8-seco-2,8-cyclo-muurol-4(5),7(11)-diene-12-oic acid (6), and (6R,10S)-6,10-dihydroxy-7,8-seco-2,8-cyclo-muurol-4(5),7(11)-diene-12- oic acid (7) were isolated from the marine sponge Dysidea cinerea. Their structures were determined by the combination of spectroscopic and chemical methods, including 1D-NMR, 2D-NMR, and CD spectra as well as by comparing the NMR data with those reported in the literature.

Original language	English
Pages (from-to)	51-56
Number of pages	6
Journal	Magnetic Resonance in Chemistry
Volume	52
Issue number	1-2
DOIs	https://doi.org/10.1002/mrc.4030
Publication status	Published - 2013 Jan

All Science Journal Classification (ASJC) codes

Chemistry(all)
Materials Science(all)

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10.1002/mrc.4030

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@article{09dd738039e346809746c84a796076c9,

title = "Muurolane-type sesquiterpenes from marine sponge Dysidea cinerea",

abstract = "Seven new muurolane-type sesquiterpenes, (4R,5R)-muurol-1(6),10(14)-diene- 4,5-diol (1), (4R,5R)-muurol-1(6)-ene-4,5-diol (2), (4R,5R,10R)-10- methoxymuurol-1(6)-ene-4,5-diol (3), (4S)-4-hydroxy-1,10-seco-muurol-5-ene-1,10- dione (4), (4R)-4-hydroxy- 1,10-seco-muurol-5-ene-1,10-dione (5), (6S,10S)-6,10-dihydroxy-7,8-seco-2,8-cyclo-muurol-4(5),7(11)-diene-12-oic acid (6), and (6R,10S)-6,10-dihydroxy-7,8-seco-2,8-cyclo-muurol-4(5),7(11)-diene-12- oic acid (7) were isolated from the marine sponge Dysidea cinerea. Their structures were determined by the combination of spectroscopic and chemical methods, including 1D-NMR, 2D-NMR, and CD spectra as well as by comparing the NMR data with those reported in the literature.",

author = "{Van Kiem}, Phan and {Van Minh}, Chau and Nhiem, {Nguyen Xuan} and Cuc, {Nguyen Thi} and {Van Quang}, Ngo and Anh, {Hoang Le Tuan} and Tai, {Bui Huu} and Yen, {Pham Hai} and Hoai, {Nguyen Thi} and Ho, {Kim Young} and Nanyoung Kim and Park, {Seon Ju} and Kim, {Seung Hyun}",

year = "2013",

month = jan,

doi = "10.1002/mrc.4030",

language = "English",

volume = "52",

pages = "51--56",

journal = "Magnetic Resonance in Chemistry",

issn = "0749-1581",

publisher = "John Wiley and Sons Ltd",

number = "1-2",

}

TY - JOUR

T1 - Muurolane-type sesquiterpenes from marine sponge Dysidea cinerea

AU - Van Kiem, Phan

AU - Van Minh, Chau

AU - Nhiem, Nguyen Xuan

AU - Cuc, Nguyen Thi

AU - Van Quang, Ngo

AU - Anh, Hoang Le Tuan

AU - Tai, Bui Huu

AU - Yen, Pham Hai

AU - Hoai, Nguyen Thi

AU - Ho, Kim Young

AU - Kim, Nanyoung

AU - Park, Seon Ju

AU - Kim, Seung Hyun

PY - 2013/1

Y1 - 2013/1

N2 - Seven new muurolane-type sesquiterpenes, (4R,5R)-muurol-1(6),10(14)-diene- 4,5-diol (1), (4R,5R)-muurol-1(6)-ene-4,5-diol (2), (4R,5R,10R)-10- methoxymuurol-1(6)-ene-4,5-diol (3), (4S)-4-hydroxy-1,10-seco-muurol-5-ene-1,10- dione (4), (4R)-4-hydroxy- 1,10-seco-muurol-5-ene-1,10-dione (5), (6S,10S)-6,10-dihydroxy-7,8-seco-2,8-cyclo-muurol-4(5),7(11)-diene-12-oic acid (6), and (6R,10S)-6,10-dihydroxy-7,8-seco-2,8-cyclo-muurol-4(5),7(11)-diene-12- oic acid (7) were isolated from the marine sponge Dysidea cinerea. Their structures were determined by the combination of spectroscopic and chemical methods, including 1D-NMR, 2D-NMR, and CD spectra as well as by comparing the NMR data with those reported in the literature.

AB - Seven new muurolane-type sesquiterpenes, (4R,5R)-muurol-1(6),10(14)-diene- 4,5-diol (1), (4R,5R)-muurol-1(6)-ene-4,5-diol (2), (4R,5R,10R)-10- methoxymuurol-1(6)-ene-4,5-diol (3), (4S)-4-hydroxy-1,10-seco-muurol-5-ene-1,10- dione (4), (4R)-4-hydroxy- 1,10-seco-muurol-5-ene-1,10-dione (5), (6S,10S)-6,10-dihydroxy-7,8-seco-2,8-cyclo-muurol-4(5),7(11)-diene-12-oic acid (6), and (6R,10S)-6,10-dihydroxy-7,8-seco-2,8-cyclo-muurol-4(5),7(11)-diene-12- oic acid (7) were isolated from the marine sponge Dysidea cinerea. Their structures were determined by the combination of spectroscopic and chemical methods, including 1D-NMR, 2D-NMR, and CD spectra as well as by comparing the NMR data with those reported in the literature.

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DO - 10.1002/mrc.4030

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JO - Magnetic Resonance in Chemistry

JF - Magnetic Resonance in Chemistry

SN - 0749-1581

IS - 1-2

ER -

Muurolane-type sesquiterpenes from marine sponge Dysidea cinerea

Abstract

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