TY - JOUR
T1 - Mycobacterial aetiology of Crohn's disease
T2 - Serologic study using common mycobacterial antigens and a species-specific glycolipid antigen from Mycobacterium paratuberculosis
AU - Cho, S. N.
AU - Brennan, P. J.
AU - Yoshimura, H. H.
AU - Korelitz, B. I.
AU - Graham, D. Y.
PY - 1986
Y1 - 1986
N2 - Crohn's disease is a granulomatous form of enteritis superficially similar to Johne's disease (paratuberculosis) of ruminants. Recently, a Mycobacterium sp closely related to Mycobacterium paratuberculosis was cultured from tissues of patients with Crohn's disease suggesting that M paratuberculosis may be the aetiologic agent in some cases. In addition, greater seroreactivity to M paratuberculosis has been reported in patients with Crohn's disease. In the present study, we have evaluated the serum antibody response to disrupted M paratuberculosis using ELISA and serum specimens from 33 people with Crohn's disease, 21 with ulcerative colitis, and 12 non-inflammatory bowel disease controls. We failed to find a consistent IgG, IgM, or IgA antibody response to Mycobacterium paratuberculosis. The results indicate that, as in bovine paratuberculosis, serum seroreactivity is not a reliable tool for examining the relationship between human intestinal diseases and mycobacteria.
AB - Crohn's disease is a granulomatous form of enteritis superficially similar to Johne's disease (paratuberculosis) of ruminants. Recently, a Mycobacterium sp closely related to Mycobacterium paratuberculosis was cultured from tissues of patients with Crohn's disease suggesting that M paratuberculosis may be the aetiologic agent in some cases. In addition, greater seroreactivity to M paratuberculosis has been reported in patients with Crohn's disease. In the present study, we have evaluated the serum antibody response to disrupted M paratuberculosis using ELISA and serum specimens from 33 people with Crohn's disease, 21 with ulcerative colitis, and 12 non-inflammatory bowel disease controls. We failed to find a consistent IgG, IgM, or IgA antibody response to Mycobacterium paratuberculosis. The results indicate that, as in bovine paratuberculosis, serum seroreactivity is not a reliable tool for examining the relationship between human intestinal diseases and mycobacteria.
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U2 - 10.1136/gut.27.11.1353
DO - 10.1136/gut.27.11.1353
M3 - Article
C2 - 3792917
AN - SCOPUS:0022976741
VL - 27
SP - 1353
EP - 1356
JO - Gut
JF - Gut
SN - 0017-5749
IS - 11
ER -
