Mycobacterium abscessus D-alanyl-D-alanine dipeptidase induces the maturation of dendritic cells and promotes Th1-biased immunity

Seung Jun Lee, Jong Hwa Jang, Gun Young Yoon, Da Rae Kang, Hee Jo Park, Sung Jae Shin, Hee Dong Han, Tae Heung Kang, Won Sun Park, Young Kyung Yoon, Byoung Yul Soh, In Duk Jung, Yeong Min Park

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Mycobacterium abscessus, a member of the group of non-tuberculous mycobacteria, has been identified as an emerging pulmonary pathogen in humans. However, little is known about the protective immune response of antigenpresenting cells, such as dendritic cells (DCs), which guard against M. abscessus infection. The M. abscessus gene MAB1843 encodes D-alanyl-D-alanine dipeptidase, which catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide. We investigated whether MAB1843 is able to interact with DCs to enhance the effectiveness of the host's immune response. MAB1843 was found to induce DC maturation via toll-like receptor 4 and its downstream signaling pathways, such as the mitogen-activated protein kinase and nuclear factor kappa B pathways. In addition, MAB1843-treated DCs stimulated the proliferation of T cells and promoted Th1 polarization. Our results indicate that MAB1843 could potentially regulate the immune response to M. abscessus, making it important in the development of an effective vaccine against this mycobacterium.

Original languageEnglish
Pages (from-to)554-559
Number of pages6
JournalBMB reports
Volume49
Issue number10
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Mycobacterium
Alanine
Dendritic Cells
Immunity
Toll-Like Receptor 4
T-cells
NF-kappa B
Dipeptides
Pathogens
Mitogen-Activated Protein Kinases
Hydrolysis
Vaccines
Genes
Cell Proliferation
Polarization
T-Lymphocytes
Lung
dipeptidase D
dipeptidase
Infection

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

Lee, Seung Jun ; Jang, Jong Hwa ; Yoon, Gun Young ; Kang, Da Rae ; Park, Hee Jo ; Shin, Sung Jae ; Han, Hee Dong ; Kang, Tae Heung ; Park, Won Sun ; Yoon, Young Kyung ; Soh, Byoung Yul ; Jung, In Duk ; Park, Yeong Min. / Mycobacterium abscessus D-alanyl-D-alanine dipeptidase induces the maturation of dendritic cells and promotes Th1-biased immunity. In: BMB reports. 2016 ; Vol. 49, No. 10. pp. 554-559.
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abstract = "Mycobacterium abscessus, a member of the group of non-tuberculous mycobacteria, has been identified as an emerging pulmonary pathogen in humans. However, little is known about the protective immune response of antigenpresenting cells, such as dendritic cells (DCs), which guard against M. abscessus infection. The M. abscessus gene MAB1843 encodes D-alanyl-D-alanine dipeptidase, which catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide. We investigated whether MAB1843 is able to interact with DCs to enhance the effectiveness of the host's immune response. MAB1843 was found to induce DC maturation via toll-like receptor 4 and its downstream signaling pathways, such as the mitogen-activated protein kinase and nuclear factor kappa B pathways. In addition, MAB1843-treated DCs stimulated the proliferation of T cells and promoted Th1 polarization. Our results indicate that MAB1843 could potentially regulate the immune response to M. abscessus, making it important in the development of an effective vaccine against this mycobacterium.",
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Lee, SJ, Jang, JH, Yoon, GY, Kang, DR, Park, HJ, Shin, SJ, Han, HD, Kang, TH, Park, WS, Yoon, YK, Soh, BY, Jung, ID & Park, YM 2016, 'Mycobacterium abscessus D-alanyl-D-alanine dipeptidase induces the maturation of dendritic cells and promotes Th1-biased immunity', BMB reports, vol. 49, no. 10, pp. 554-559. https://doi.org/10.5483/BMBRep.2016.49.10.080

Mycobacterium abscessus D-alanyl-D-alanine dipeptidase induces the maturation of dendritic cells and promotes Th1-biased immunity. / Lee, Seung Jun; Jang, Jong Hwa; Yoon, Gun Young; Kang, Da Rae; Park, Hee Jo; Shin, Sung Jae; Han, Hee Dong; Kang, Tae Heung; Park, Won Sun; Yoon, Young Kyung; Soh, Byoung Yul; Jung, In Duk; Park, Yeong Min.

In: BMB reports, Vol. 49, No. 10, 01.01.2016, p. 554-559.

Research output: Contribution to journalArticle

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AU - Lee, Seung Jun

AU - Jang, Jong Hwa

AU - Yoon, Gun Young

AU - Kang, Da Rae

AU - Park, Hee Jo

AU - Shin, Sung Jae

AU - Han, Hee Dong

AU - Kang, Tae Heung

AU - Park, Won Sun

AU - Yoon, Young Kyung

AU - Soh, Byoung Yul

AU - Jung, In Duk

AU - Park, Yeong Min

PY - 2016/1/1

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N2 - Mycobacterium abscessus, a member of the group of non-tuberculous mycobacteria, has been identified as an emerging pulmonary pathogen in humans. However, little is known about the protective immune response of antigenpresenting cells, such as dendritic cells (DCs), which guard against M. abscessus infection. The M. abscessus gene MAB1843 encodes D-alanyl-D-alanine dipeptidase, which catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide. We investigated whether MAB1843 is able to interact with DCs to enhance the effectiveness of the host's immune response. MAB1843 was found to induce DC maturation via toll-like receptor 4 and its downstream signaling pathways, such as the mitogen-activated protein kinase and nuclear factor kappa B pathways. In addition, MAB1843-treated DCs stimulated the proliferation of T cells and promoted Th1 polarization. Our results indicate that MAB1843 could potentially regulate the immune response to M. abscessus, making it important in the development of an effective vaccine against this mycobacterium.

AB - Mycobacterium abscessus, a member of the group of non-tuberculous mycobacteria, has been identified as an emerging pulmonary pathogen in humans. However, little is known about the protective immune response of antigenpresenting cells, such as dendritic cells (DCs), which guard against M. abscessus infection. The M. abscessus gene MAB1843 encodes D-alanyl-D-alanine dipeptidase, which catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide. We investigated whether MAB1843 is able to interact with DCs to enhance the effectiveness of the host's immune response. MAB1843 was found to induce DC maturation via toll-like receptor 4 and its downstream signaling pathways, such as the mitogen-activated protein kinase and nuclear factor kappa B pathways. In addition, MAB1843-treated DCs stimulated the proliferation of T cells and promoted Th1 polarization. Our results indicate that MAB1843 could potentially regulate the immune response to M. abscessus, making it important in the development of an effective vaccine against this mycobacterium.

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