Mycobacterium tuberculosis lpdC, Rv0462, induces dendritic cell maturation and Th1 polarization

Deok Rim Heo, Sung Jae Shin, Woo Sik Kim, Kyung Tae Noh, Jin Wook Park, Kwang Hee Son, Won Sun Park, Min Goo Lee, Daejin Kim, Yong Kyoo Shin, In Duk Jung, Yeong Min Park

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Mycobacterium tuberculosis, the etiological factor of pulmonary tuberculosis, causes significant morbidity and mortality worldwide. Activation of host immune responses for containment of mycobacterial infections involves participation of innate immune cells, such as dendritic cells (DCs). In this study, we demonstrated that the gene encoding lipoamide dehydrogenase C (lpdC) from M. tuberculosis, Rv0462, induce maturation and activation of DCs involved in the MAPKs signaling pathway. Moreover, Rv0462-treated DCs activated naïve T cells, polarized CD4+ and CD8+ T cells to secrete IFN-γ in syngeneic mixed lymphocyte reactions, which would be expected to contribute to Th1 polarization of the immune response. Our results suggest that Rv0462 can contribute to the innate and adaptive immune responses during tuberculosis infection, and thus modulate the clinical course of tuberculosis.

Original languageEnglish
Pages (from-to)642-647
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume411
Issue number3
DOIs
Publication statusPublished - 2011 Aug 5

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health Welfare & Family Affairs, Republic of Korea ( A091047-1012-0000300 ) and was financially supported by Pusan National University in program (Post-Doc. 2010).

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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