Mycobacterium tuberculosis MmsA, a novel immunostimulatory antigen, induces dendritic cell activation and promotes Th1 cell-type immune responses

Jong Seok Kim, Woo Sik Kim, Hong Hee Choi, Hong Min Kim, Kee Woong Kwon, Seung Jung Han, Seung Bin Cha, Sangnae Cho, Won Jung Koh, SungJae Shin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is an outstanding pathogen that modulates the host immune response. This inconvenient truth drives the continual identification of antigens that generate protective immunity, including Th1-type T cell immunity. Here, the contribution of methylmalonate semialdehyde dehydrogenase (MmsA, Rv0753c) of Mtb to immune responses was examined in the context of dendritic cell (DC) activation and T cell immunity both in vitro and in vivo. The results showed that MmsA induced DC activation by activating the MAPK and NF-κB signaling pathways. Additionally, MmsA-treated DCs activated naïve T cells, effectively polarized CD4 + and CD8 + T cells to secrete IFN-γ and IL-2, and induced T cell proliferation. These results indicate that MmsA is a novel DC maturation-inducing antigen that drives the Th1 immune response. Thus, MmsA was found to potentially regulate immune responses via DC activation toward Th1-type T cell immunity, enhancing our understanding of Mtb pathogenesis.

Original languageEnglish
Pages (from-to)115-125
Number of pages11
JournalCellular Immunology
Volume298
Issue number1-2
DOIs
Publication statusPublished - 2015 Nov 1

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Th1 Cells
Mycobacterium tuberculosis
Dendritic Cells
T-Lymphocytes
Antigens
Immunity
Interleukin-2
Oxidoreductases
Tuberculosis
Cell Proliferation

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Kim, Jong Seok ; Kim, Woo Sik ; Choi, Hong Hee ; Kim, Hong Min ; Kwon, Kee Woong ; Han, Seung Jung ; Cha, Seung Bin ; Cho, Sangnae ; Koh, Won Jung ; Shin, SungJae. / Mycobacterium tuberculosis MmsA, a novel immunostimulatory antigen, induces dendritic cell activation and promotes Th1 cell-type immune responses. In: Cellular Immunology. 2015 ; Vol. 298, No. 1-2. pp. 115-125.
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Mycobacterium tuberculosis MmsA, a novel immunostimulatory antigen, induces dendritic cell activation and promotes Th1 cell-type immune responses. / Kim, Jong Seok; Kim, Woo Sik; Choi, Hong Hee; Kim, Hong Min; Kwon, Kee Woong; Han, Seung Jung; Cha, Seung Bin; Cho, Sangnae; Koh, Won Jung; Shin, SungJae.

In: Cellular Immunology, Vol. 298, No. 1-2, 01.11.2015, p. 115-125.

Research output: Contribution to journalArticle

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AU - Kwon, Kee Woong

AU - Han, Seung Jung

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