Myocardial Characterization Using Dual-Energy CT in Doxorubicin-Induced DCM: Comparison With CMR T1-Mapping and Histology in a Rabbit Model

Yoo Jin Hong, Tai Kyung Kim, Donghyun Hong, Chul Hwan Park, Sae Jong Yoo, Mary Ellen Wickum, Jin Hur, Hye Jeong Lee, Young Jin Kim, Young Joo Suh, Andreas Greiser, Mun Young Paek, Byoung Wook Choi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objectives This study sought to evaluate whether patterns of myocardial change in doxorubicin-induced dilated cardiomyopathy determined using dual-energy computed tomography (CT) were similar to characterization by extracellular volume fraction (ECV) using cardiac magnetic resonance (CMR) T1-mapping and collagen volume fraction (CVF) measured using histology. Background Anthracycline chemoagents are effective against a wide range of malignant conditions. However, cardiotoxicity is a well-known adverse effect of these drugs. Dual-energy CT could be as useful as magnetic resonance (MR) to evaluate myocardial change in anthracycline-induced cardiotoxicity. Methods A dilated cardiomyopathy rabbit model was generated by injecting 11 adult New Zealand rabbits with 1.0 mg/kg of doxorubicin twice weekly for 16 weeks. Contrast-enhanced dual-energy CT and pre-contrast and post-contrast T1-mapping CMR using a prototype modified Look-Locker inversion recovery on a clinical 3-T scanner were performed on 15 rabbits, including 4 control animals, to calculate ECV at baseline, and at 6, 12, and 16 weeks after doxorubicin administration. Results The mean ECV values (%) on CT and CMR at 6, 12, and 16 weeks after modeling were significantly higher than those measured at baseline (CT ECV: 35.3%, 41.9%, 42.1% vs. 28.5%; MR ECV: 32.6%, 35.8%, 41.3% vs. 28.8%, respectively; all p < 0.001). CT ECV and MR ECV values were well correlated (r = 0.888; p < 0.001). Both were well correlated with CVF on histology (CT ECV vs. CVF, r = 0.925, p < 0.001 and MR ECV vs. CVF, r = 0.961, p < 0.001, respectively). Conclusions Dual-energy CT ECV correlated well with CMR and histology. Dual-energy CT is useful for characterizing doxorubicin-induced cardiomyopathy by measuring ECV fraction; however, further technical improvements are desirable to lower motion artifact and improve image quality of the iodine map.

Original languageEnglish
Pages (from-to)836-845
Number of pages10
JournalJACC: Cardiovascular Imaging
Volume9
Issue number7
DOIs
Publication statusPublished - 2016 Jul 1

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Doxorubicin
Magnetic Resonance Spectroscopy
Tomography
Rabbits
Cone-Beam Computed Tomography
Collagen
Histology
Anthracyclines
Dilated Cardiomyopathy
Cardiomyopathies
Iodine
Artifacts
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Hong, Yoo Jin ; Kim, Tai Kyung ; Hong, Donghyun ; Park, Chul Hwan ; Yoo, Sae Jong ; Wickum, Mary Ellen ; Hur, Jin ; Lee, Hye Jeong ; Kim, Young Jin ; Suh, Young Joo ; Greiser, Andreas ; Paek, Mun Young ; Choi, Byoung Wook. / Myocardial Characterization Using Dual-Energy CT in Doxorubicin-Induced DCM : Comparison With CMR T1-Mapping and Histology in a Rabbit Model. In: JACC: Cardiovascular Imaging. 2016 ; Vol. 9, No. 7. pp. 836-845.
@article{92be24afb6b84982b4accd7d07e42802,
title = "Myocardial Characterization Using Dual-Energy CT in Doxorubicin-Induced DCM: Comparison With CMR T1-Mapping and Histology in a Rabbit Model",
abstract = "Objectives This study sought to evaluate whether patterns of myocardial change in doxorubicin-induced dilated cardiomyopathy determined using dual-energy computed tomography (CT) were similar to characterization by extracellular volume fraction (ECV) using cardiac magnetic resonance (CMR) T1-mapping and collagen volume fraction (CVF) measured using histology. Background Anthracycline chemoagents are effective against a wide range of malignant conditions. However, cardiotoxicity is a well-known adverse effect of these drugs. Dual-energy CT could be as useful as magnetic resonance (MR) to evaluate myocardial change in anthracycline-induced cardiotoxicity. Methods A dilated cardiomyopathy rabbit model was generated by injecting 11 adult New Zealand rabbits with 1.0 mg/kg of doxorubicin twice weekly for 16 weeks. Contrast-enhanced dual-energy CT and pre-contrast and post-contrast T1-mapping CMR using a prototype modified Look-Locker inversion recovery on a clinical 3-T scanner were performed on 15 rabbits, including 4 control animals, to calculate ECV at baseline, and at 6, 12, and 16 weeks after doxorubicin administration. Results The mean ECV values ({\%}) on CT and CMR at 6, 12, and 16 weeks after modeling were significantly higher than those measured at baseline (CT ECV: 35.3{\%}, 41.9{\%}, 42.1{\%} vs. 28.5{\%}; MR ECV: 32.6{\%}, 35.8{\%}, 41.3{\%} vs. 28.8{\%}, respectively; all p < 0.001). CT ECV and MR ECV values were well correlated (r = 0.888; p < 0.001). Both were well correlated with CVF on histology (CT ECV vs. CVF, r = 0.925, p < 0.001 and MR ECV vs. CVF, r = 0.961, p < 0.001, respectively). Conclusions Dual-energy CT ECV correlated well with CMR and histology. Dual-energy CT is useful for characterizing doxorubicin-induced cardiomyopathy by measuring ECV fraction; however, further technical improvements are desirable to lower motion artifact and improve image quality of the iodine map.",
author = "Hong, {Yoo Jin} and Kim, {Tai Kyung} and Donghyun Hong and Park, {Chul Hwan} and Yoo, {Sae Jong} and Wickum, {Mary Ellen} and Jin Hur and Lee, {Hye Jeong} and Kim, {Young Jin} and Suh, {Young Joo} and Andreas Greiser and Paek, {Mun Young} and Choi, {Byoung Wook}",
year = "2016",
month = "7",
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doi = "10.1016/j.jcmg.2015.12.018",
language = "English",
volume = "9",
pages = "836--845",
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}

Hong, YJ, Kim, TK, Hong, D, Park, CH, Yoo, SJ, Wickum, ME, Hur, J, Lee, HJ, Kim, YJ, Suh, YJ, Greiser, A, Paek, MY & Choi, BW 2016, 'Myocardial Characterization Using Dual-Energy CT in Doxorubicin-Induced DCM: Comparison With CMR T1-Mapping and Histology in a Rabbit Model', JACC: Cardiovascular Imaging, vol. 9, no. 7, pp. 836-845. https://doi.org/10.1016/j.jcmg.2015.12.018

Myocardial Characterization Using Dual-Energy CT in Doxorubicin-Induced DCM : Comparison With CMR T1-Mapping and Histology in a Rabbit Model. / Hong, Yoo Jin; Kim, Tai Kyung; Hong, Donghyun; Park, Chul Hwan; Yoo, Sae Jong; Wickum, Mary Ellen; Hur, Jin; Lee, Hye Jeong; Kim, Young Jin; Suh, Young Joo; Greiser, Andreas; Paek, Mun Young; Choi, Byoung Wook.

In: JACC: Cardiovascular Imaging, Vol. 9, No. 7, 01.07.2016, p. 836-845.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Myocardial Characterization Using Dual-Energy CT in Doxorubicin-Induced DCM

T2 - Comparison With CMR T1-Mapping and Histology in a Rabbit Model

AU - Hong, Yoo Jin

AU - Kim, Tai Kyung

AU - Hong, Donghyun

AU - Park, Chul Hwan

AU - Yoo, Sae Jong

AU - Wickum, Mary Ellen

AU - Hur, Jin

AU - Lee, Hye Jeong

AU - Kim, Young Jin

AU - Suh, Young Joo

AU - Greiser, Andreas

AU - Paek, Mun Young

AU - Choi, Byoung Wook

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Objectives This study sought to evaluate whether patterns of myocardial change in doxorubicin-induced dilated cardiomyopathy determined using dual-energy computed tomography (CT) were similar to characterization by extracellular volume fraction (ECV) using cardiac magnetic resonance (CMR) T1-mapping and collagen volume fraction (CVF) measured using histology. Background Anthracycline chemoagents are effective against a wide range of malignant conditions. However, cardiotoxicity is a well-known adverse effect of these drugs. Dual-energy CT could be as useful as magnetic resonance (MR) to evaluate myocardial change in anthracycline-induced cardiotoxicity. Methods A dilated cardiomyopathy rabbit model was generated by injecting 11 adult New Zealand rabbits with 1.0 mg/kg of doxorubicin twice weekly for 16 weeks. Contrast-enhanced dual-energy CT and pre-contrast and post-contrast T1-mapping CMR using a prototype modified Look-Locker inversion recovery on a clinical 3-T scanner were performed on 15 rabbits, including 4 control animals, to calculate ECV at baseline, and at 6, 12, and 16 weeks after doxorubicin administration. Results The mean ECV values (%) on CT and CMR at 6, 12, and 16 weeks after modeling were significantly higher than those measured at baseline (CT ECV: 35.3%, 41.9%, 42.1% vs. 28.5%; MR ECV: 32.6%, 35.8%, 41.3% vs. 28.8%, respectively; all p < 0.001). CT ECV and MR ECV values were well correlated (r = 0.888; p < 0.001). Both were well correlated with CVF on histology (CT ECV vs. CVF, r = 0.925, p < 0.001 and MR ECV vs. CVF, r = 0.961, p < 0.001, respectively). Conclusions Dual-energy CT ECV correlated well with CMR and histology. Dual-energy CT is useful for characterizing doxorubicin-induced cardiomyopathy by measuring ECV fraction; however, further technical improvements are desirable to lower motion artifact and improve image quality of the iodine map.

AB - Objectives This study sought to evaluate whether patterns of myocardial change in doxorubicin-induced dilated cardiomyopathy determined using dual-energy computed tomography (CT) were similar to characterization by extracellular volume fraction (ECV) using cardiac magnetic resonance (CMR) T1-mapping and collagen volume fraction (CVF) measured using histology. Background Anthracycline chemoagents are effective against a wide range of malignant conditions. However, cardiotoxicity is a well-known adverse effect of these drugs. Dual-energy CT could be as useful as magnetic resonance (MR) to evaluate myocardial change in anthracycline-induced cardiotoxicity. Methods A dilated cardiomyopathy rabbit model was generated by injecting 11 adult New Zealand rabbits with 1.0 mg/kg of doxorubicin twice weekly for 16 weeks. Contrast-enhanced dual-energy CT and pre-contrast and post-contrast T1-mapping CMR using a prototype modified Look-Locker inversion recovery on a clinical 3-T scanner were performed on 15 rabbits, including 4 control animals, to calculate ECV at baseline, and at 6, 12, and 16 weeks after doxorubicin administration. Results The mean ECV values (%) on CT and CMR at 6, 12, and 16 weeks after modeling were significantly higher than those measured at baseline (CT ECV: 35.3%, 41.9%, 42.1% vs. 28.5%; MR ECV: 32.6%, 35.8%, 41.3% vs. 28.8%, respectively; all p < 0.001). CT ECV and MR ECV values were well correlated (r = 0.888; p < 0.001). Both were well correlated with CVF on histology (CT ECV vs. CVF, r = 0.925, p < 0.001 and MR ECV vs. CVF, r = 0.961, p < 0.001, respectively). Conclusions Dual-energy CT ECV correlated well with CMR and histology. Dual-energy CT is useful for characterizing doxorubicin-induced cardiomyopathy by measuring ECV fraction; however, further technical improvements are desirable to lower motion artifact and improve image quality of the iodine map.

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