Myocardial extracellular volume fraction and change in hematocrit level: MR evaluation by using T1 mapping in an experimental model of Anemia

Pan Ki Kim, Yoo Jin Hong, Hajime Sakuma, Ashish Chawla, Jeffrey Kihyun Park, Chul Hwan Park, Donghyun Hong, Kyunghwa Han, Ji Yeon Lee, Jin Hur, Hye Jeong Lee, Young Jin Kim, Young Joo Suh, Byoung Wook Choi

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Abstract

Purpose: To evaluate the effect of changes in hematocrit level on myocardial extracellular volume (ECV) fraction, as quantified with cardiac magnetic resonance (MR) imaging in an animal model. Materials and Methods: Thirteen adult male Sprague-Dawley rats underwent cardiac MR imaging before and after induction of anemia. MR imaging procedures, including unenhanced and contrast material–enhanced T1 mapping, were performed by using a saturation recovery Look-Locker sequence with a 9.4-T unit. An optimized T1 mapping sequence was established in the phantom study. Systolic function of the left ventricle (LV) was calculated from the cine images. Native and postcontrast T1 values of the LV myocardium at the midcavity level and LV blood pool, partition coefficients, and ECV were calculated. Histopathologic examination of the heart was performed after sacrifice. Intergroup comparison of variables was performed with the paired t test. Results: The postanemia models exhibited lower hematocrit levels, postcontrast T1 values of the LV pool, and partition coefficients (mean, 45.7% 6 5.2 [standard deviation]; 563.8 msec 6 155.7; and 29.2 6 3.5, respectively) than did the preanemia models (mean, 59.0% 6 4.1; 690.2 msec 6 109.7; and 38.2 6 4.4, respectively) (P , .05 for all comparisons). There were no differences between the pre- and postanemia groups in terms of LV ejection fraction (mean, 72.7% 6 2.1 vs 73.2% 6 4.7; P = .78) and ECV (mean, 15.5% 6 2.0 vs 16.0% 6 1.9; P = .24). Conclusion: Myocardial ECV measured with contrast-enhanced T1 mapping cardiac MR imaging did not significantly change despite changes in hematocrit level in anemic rat models. Extrapolation of this finding from animal models to human subjects suggests that ECV measured with MR imaging could be a robust parameter in anemic patients.

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalRadiology
Volume288
Issue number1
DOIs
Publication statusPublished - 2018 Jul

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Hematocrit
Heart Ventricles
Anemia
Theoretical Models
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Animal Models
Sprague Dawley Rats
Myocardium

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Kim, Pan Ki ; Hong, Yoo Jin ; Sakuma, Hajime ; Chawla, Ashish ; Park, Jeffrey Kihyun ; Park, Chul Hwan ; Hong, Donghyun ; Han, Kyunghwa ; Lee, Ji Yeon ; Hur, Jin ; Lee, Hye Jeong ; Kim, Young Jin ; Suh, Young Joo ; Choi, Byoung Wook. / Myocardial extracellular volume fraction and change in hematocrit level : MR evaluation by using T1 mapping in an experimental model of Anemia. In: Radiology. 2018 ; Vol. 288, No. 1. pp. 93-98.
@article{53acf436a7134f2fb903aa8e87441eae,
title = "Myocardial extracellular volume fraction and change in hematocrit level: MR evaluation by using T1 mapping in an experimental model of Anemia",
abstract = "Purpose: To evaluate the effect of changes in hematocrit level on myocardial extracellular volume (ECV) fraction, as quantified with cardiac magnetic resonance (MR) imaging in an animal model. Materials and Methods: Thirteen adult male Sprague-Dawley rats underwent cardiac MR imaging before and after induction of anemia. MR imaging procedures, including unenhanced and contrast material–enhanced T1 mapping, were performed by using a saturation recovery Look-Locker sequence with a 9.4-T unit. An optimized T1 mapping sequence was established in the phantom study. Systolic function of the left ventricle (LV) was calculated from the cine images. Native and postcontrast T1 values of the LV myocardium at the midcavity level and LV blood pool, partition coefficients, and ECV were calculated. Histopathologic examination of the heart was performed after sacrifice. Intergroup comparison of variables was performed with the paired t test. Results: The postanemia models exhibited lower hematocrit levels, postcontrast T1 values of the LV pool, and partition coefficients (mean, 45.7{\%} 6 5.2 [standard deviation]; 563.8 msec 6 155.7; and 29.2 6 3.5, respectively) than did the preanemia models (mean, 59.0{\%} 6 4.1; 690.2 msec 6 109.7; and 38.2 6 4.4, respectively) (P , .05 for all comparisons). There were no differences between the pre- and postanemia groups in terms of LV ejection fraction (mean, 72.7{\%} 6 2.1 vs 73.2{\%} 6 4.7; P = .78) and ECV (mean, 15.5{\%} 6 2.0 vs 16.0{\%} 6 1.9; P = .24). Conclusion: Myocardial ECV measured with contrast-enhanced T1 mapping cardiac MR imaging did not significantly change despite changes in hematocrit level in anemic rat models. Extrapolation of this finding from animal models to human subjects suggests that ECV measured with MR imaging could be a robust parameter in anemic patients.",
author = "Kim, {Pan Ki} and Hong, {Yoo Jin} and Hajime Sakuma and Ashish Chawla and Park, {Jeffrey Kihyun} and Park, {Chul Hwan} and Donghyun Hong and Kyunghwa Han and Lee, {Ji Yeon} and Jin Hur and Lee, {Hye Jeong} and Kim, {Young Jin} and Suh, {Young Joo} and Choi, {Byoung Wook}",
year = "2018",
month = "7",
doi = "10.1148/radiol.2018171342",
language = "English",
volume = "288",
pages = "93--98",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "1",

}

Kim, PK, Hong, YJ, Sakuma, H, Chawla, A, Park, JK, Park, CH, Hong, D, Han, K, Lee, JY, Hur, J, Lee, HJ, Kim, YJ, Suh, YJ & Choi, BW 2018, 'Myocardial extracellular volume fraction and change in hematocrit level: MR evaluation by using T1 mapping in an experimental model of Anemia', Radiology, vol. 288, no. 1, pp. 93-98. https://doi.org/10.1148/radiol.2018171342

Myocardial extracellular volume fraction and change in hematocrit level : MR evaluation by using T1 mapping in an experimental model of Anemia. / Kim, Pan Ki; Hong, Yoo Jin; Sakuma, Hajime; Chawla, Ashish; Park, Jeffrey Kihyun; Park, Chul Hwan; Hong, Donghyun; Han, Kyunghwa; Lee, Ji Yeon; Hur, Jin; Lee, Hye Jeong; Kim, Young Jin; Suh, Young Joo; Choi, Byoung Wook.

In: Radiology, Vol. 288, No. 1, 07.2018, p. 93-98.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Myocardial extracellular volume fraction and change in hematocrit level

T2 - MR evaluation by using T1 mapping in an experimental model of Anemia

AU - Kim, Pan Ki

AU - Hong, Yoo Jin

AU - Sakuma, Hajime

AU - Chawla, Ashish

AU - Park, Jeffrey Kihyun

AU - Park, Chul Hwan

AU - Hong, Donghyun

AU - Han, Kyunghwa

AU - Lee, Ji Yeon

AU - Hur, Jin

AU - Lee, Hye Jeong

AU - Kim, Young Jin

AU - Suh, Young Joo

AU - Choi, Byoung Wook

PY - 2018/7

Y1 - 2018/7

N2 - Purpose: To evaluate the effect of changes in hematocrit level on myocardial extracellular volume (ECV) fraction, as quantified with cardiac magnetic resonance (MR) imaging in an animal model. Materials and Methods: Thirteen adult male Sprague-Dawley rats underwent cardiac MR imaging before and after induction of anemia. MR imaging procedures, including unenhanced and contrast material–enhanced T1 mapping, were performed by using a saturation recovery Look-Locker sequence with a 9.4-T unit. An optimized T1 mapping sequence was established in the phantom study. Systolic function of the left ventricle (LV) was calculated from the cine images. Native and postcontrast T1 values of the LV myocardium at the midcavity level and LV blood pool, partition coefficients, and ECV were calculated. Histopathologic examination of the heart was performed after sacrifice. Intergroup comparison of variables was performed with the paired t test. Results: The postanemia models exhibited lower hematocrit levels, postcontrast T1 values of the LV pool, and partition coefficients (mean, 45.7% 6 5.2 [standard deviation]; 563.8 msec 6 155.7; and 29.2 6 3.5, respectively) than did the preanemia models (mean, 59.0% 6 4.1; 690.2 msec 6 109.7; and 38.2 6 4.4, respectively) (P , .05 for all comparisons). There were no differences between the pre- and postanemia groups in terms of LV ejection fraction (mean, 72.7% 6 2.1 vs 73.2% 6 4.7; P = .78) and ECV (mean, 15.5% 6 2.0 vs 16.0% 6 1.9; P = .24). Conclusion: Myocardial ECV measured with contrast-enhanced T1 mapping cardiac MR imaging did not significantly change despite changes in hematocrit level in anemic rat models. Extrapolation of this finding from animal models to human subjects suggests that ECV measured with MR imaging could be a robust parameter in anemic patients.

AB - Purpose: To evaluate the effect of changes in hematocrit level on myocardial extracellular volume (ECV) fraction, as quantified with cardiac magnetic resonance (MR) imaging in an animal model. Materials and Methods: Thirteen adult male Sprague-Dawley rats underwent cardiac MR imaging before and after induction of anemia. MR imaging procedures, including unenhanced and contrast material–enhanced T1 mapping, were performed by using a saturation recovery Look-Locker sequence with a 9.4-T unit. An optimized T1 mapping sequence was established in the phantom study. Systolic function of the left ventricle (LV) was calculated from the cine images. Native and postcontrast T1 values of the LV myocardium at the midcavity level and LV blood pool, partition coefficients, and ECV were calculated. Histopathologic examination of the heart was performed after sacrifice. Intergroup comparison of variables was performed with the paired t test. Results: The postanemia models exhibited lower hematocrit levels, postcontrast T1 values of the LV pool, and partition coefficients (mean, 45.7% 6 5.2 [standard deviation]; 563.8 msec 6 155.7; and 29.2 6 3.5, respectively) than did the preanemia models (mean, 59.0% 6 4.1; 690.2 msec 6 109.7; and 38.2 6 4.4, respectively) (P , .05 for all comparisons). There were no differences between the pre- and postanemia groups in terms of LV ejection fraction (mean, 72.7% 6 2.1 vs 73.2% 6 4.7; P = .78) and ECV (mean, 15.5% 6 2.0 vs 16.0% 6 1.9; P = .24). Conclusion: Myocardial ECV measured with contrast-enhanced T1 mapping cardiac MR imaging did not significantly change despite changes in hematocrit level in anemic rat models. Extrapolation of this finding from animal models to human subjects suggests that ECV measured with MR imaging could be a robust parameter in anemic patients.

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DO - 10.1148/radiol.2018171342

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AN - SCOPUS:85050292950

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