Myocardial regeneration with bone-marrow-derived stem cells

Youngsup Yoon, Namho Lee, Heather Scadova

Research output: Contribution to journalReview article

75 Citations (Scopus)

Abstract

Despite significant therapeutic advances, heart failure remains the predominant cause of mortality in the Western world. Ischaemic cardiomyopathy and myocardial infarction are typified by the irreversible loss of cardiac muscle (cardiomyocytes) and vasculature composed of endothelial cells and smooth muscle cells, which are essential for maintaining cardiac integrity and function. The recent identification of adult and embryonic stem cells has triggered attempts to directly repopulate these tissues by stem cell transplantation as a novel therapeutic option. Reports describing provocative and hopeful examples of myocardial regeneration with adult bone-marrow-derived stem and progenitor cells have increased the enthusiasm for the use of these cells, yet many questions remain regarding their therapeutic potential and the mechanisms responsible for the observed therapeutic effects. In this review article we discuss the current preclinical and clinical advances in bone-marrow-derived stem or progenitor cell therapies for regeneration or repair of the ischaemic myocardium and their multiple related mechanisms involved in myocardial repair and regeneration.

Original languageEnglish
Pages (from-to)253-263
Number of pages11
JournalBiology of the Cell
Volume97
Issue number4
DOIs
Publication statusPublished - 2005 Apr 1

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Regeneration
Stem Cells
Bone Marrow
Myocardium
Western World
Adult Stem Cells
Stem Cell Transplantation
Therapeutic Uses
Embryonic Stem Cells
Cell- and Tissue-Based Therapy
Cardiomyopathies
Cardiac Myocytes
Smooth Muscle Myocytes
Therapeutics
Endothelial Cells
Heart Failure
Myocardial Infarction
Mortality

All Science Journal Classification (ASJC) codes

  • Cell Biology

Cite this

Yoon, Youngsup ; Lee, Namho ; Scadova, Heather. / Myocardial regeneration with bone-marrow-derived stem cells. In: Biology of the Cell. 2005 ; Vol. 97, No. 4. pp. 253-263.
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Myocardial regeneration with bone-marrow-derived stem cells. / Yoon, Youngsup; Lee, Namho; Scadova, Heather.

In: Biology of the Cell, Vol. 97, No. 4, 01.04.2005, p. 253-263.

Research output: Contribution to journalReview article

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