Myricetin exerts anti-obesity effects through upregulation of SIRT3 in adipose tissue

Seun Akindehin, Young Suk Jung, Sang Nam Kim, Yeon Ho Son, Icksoo Lee, Je Kyung Seong, Hyun Woo Jeong, Yun Hee Lee

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Abstract

Myricetin is a biologically active natural polyphenol with beneficial effects on metabolic health. This study aimed to examine the effects of myricetin on the expression levels of genes involved in lipolysis and mitochondrial respiration in adipocytes and the anti-obesity potential of myricetin. The results indicated that myricetin reduced triglyceride (TG) content and increased mitochondrial content and oxygen consumption rate (OCR) in adipocytes in vitro. To determine anti-obesity effect of myricetin, C57BL6/J mice were fed a high-fat diet (HFD) for eight weeks and then treated with myricetin (10 mg/kg) for 2 weeks. The in vivo treatment of myricetin reduced body weight by 11%. Furthermore, it improved the glucose tolerance, and increased fatty acid consumption of HFD-fed mice. Myricetin treatment increased Sirt3 expression and reduced the acetylation of mitochondrial proteins in adipose tissue. Finally, the knockdown of Sirt3 in adipocytes reduced the myricetin-induced increase in mitochondrial oxygen consumption rate by about 27% compared to controls. Our results indicated that myricetin exerted anti-obesity effects through the upregulation of Sirt3 expression and mitochondrial metabolism in adipose tissue.

Original languageEnglish
Article number1962
JournalNutrients
Volume10
Issue number12
DOIs
Publication statusPublished - 2018 Dec 12

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All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cite this

Akindehin, S., Jung, Y. S., Kim, S. N., Son, Y. H., Lee, I., Seong, J. K., Jeong, H. W., & Lee, Y. H. (2018). Myricetin exerts anti-obesity effects through upregulation of SIRT3 in adipose tissue. Nutrients, 10(12), [1962]. https://doi.org/10.3390/nu10121962