Myristoylated TMEM39AS41, a cell-permeable peptide, causes lung cancer cell death

Sungjin Park, Minhee Kim, Youngeun Hong, Hyunji Lee, Quangdon Tran, Chaeyeong Kim, So Hee Kwon, Jisoo Park, Jongsun Park, Seon Hwan Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Lung cancer is the most common cause of cancer-associated death worldwide. Most patients with non-small cell lung cancer die within several years of the initial diagnosis, and new therapies are desperately needed. Transmembrane protein (TMEM) 39AS41, a synthetic peptide, was generated from the protein kinase B substrate motif 34GLRNRNGSAIGLPVP48 found in the human TMEM39A protein. Myristic acid was conjugated to the N-terminus of the peptide to confer cell permeability. In this study, we found that in vitro TMEM39AS41 peptide led to cell death via inhibition of inflammation/autophagy pathways in KRAS-mutated cell and tissues. In addition, TMEM39A, at a dose of 30 mg/kg, significantly suppressed tumor growth in KRASLA1 non-small cell lung cancer mice. These results suggest that the TMEM39AS41 peptide could have therapeutic potential for lung cancer.

Original languageEnglish
Pages (from-to)123-130
Number of pages8
JournalToxicological Research
Volume36
Issue number2
DOIs
Publication statusPublished - 2020 Apr 1

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

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    Park, S., Kim, M., Hong, Y., Lee, H., Tran, Q., Kim, C., Kwon, S. H., Park, J., Park, J., & Kim, S. H. (2020). Myristoylated TMEM39AS41, a cell-permeable peptide, causes lung cancer cell death. Toxicological Research, 36(2), 123-130. https://doi.org/10.1007/s43188-020-00038-1