N-acetylcysteine prevents the development of gastritis induced by Helicobacter pylori infection

Sungil Jang, Eun Jung Bak, Jeong Heon Cha

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Helicobacter pylori (H. pylori) is a human gastric pathogen, causing various gastric diseases ranging from gastritis to gastric adenocarcinoma. It has been reported that combining N-acetylcysteine (NAC) with conventional antibiotic therapy increases the success rate of H. pylori eradication. We evaluated the effect of NAC itself on the growth and colonization of H. pylori, and development of gastritis, using in vitro liquid culture system and in vivo animal models. H. pylori growth was evaluated in broth culture containing NAC. The H. pylori load and histopathological scores of stomachs were measured in Mongolian gerbils infected with H. pylori strain 7.13, and fed with NAC-containing diet. In liquid culture, NAC inhibited H. pylori growth in a concentration-dependent manner. In the animal model, 3-day administration of NAC after 1 week from infection reduced the H. pylori load; 6-week administration of NAC after 1 week from infection prevented the development of gastritis and reduced H. pylori colonization. However, no reduction in the bacterial load or degree of gastritis was observed with a 6-week administration of NAC following 6-week infection period. Our results indicate that NAC may exert a beneficial effect on reduction of bacterial colonization, and prevents the development of severe inflammation, in people with initial asymptomatic or mild H. pylori infection.

Original languageEnglish
Pages (from-to)396-402
Number of pages7
JournalJournal of Microbiology
Volume55
Issue number5
DOIs
Publication statusPublished - 2017 May 1

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Acetylcysteine
Helicobacter Infections
Gastritis
Helicobacter pylori
Stomach
Animal Models
Growth
Infection
Stomach Diseases
Gerbillinae
Bacterial Load
Adenocarcinoma
Anti-Bacterial Agents
Diet
Inflammation

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Applied Microbiology and Biotechnology

Cite this

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N-acetylcysteine prevents the development of gastritis induced by Helicobacter pylori infection. / Jang, Sungil; Bak, Eun Jung; Cha, Jeong Heon.

In: Journal of Microbiology, Vol. 55, No. 5, 01.05.2017, p. 396-402.

Research output: Contribution to journalArticle

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