N euronal responses in the globus pallidus during subthalamic nucleus electrical stimulation in normal and Parkinson's disease model rats

Sang Baek Ryu, Eun Kyung Bae, Jinhyung Kim, Yong Sup Hwang, Changkyun Im, Jin Woo Chang, Hyung Cheul Shin, Kyung Hwan Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been widely used as a treatment for the movement disturbances caused by Parkinson's disease (PD). Despite successful application of DBS, its mechanism of therapeutic effect is not clearly understood. Because PD results from the degeneration of dopamine neurons that affect the basal ganglia (BG) network, investigation of neuronal responses of BG neurons during STN DBS can provide informative insights for the understanding of the mechanism of therapeutic effect. However, it is difficult to observe neuronal activity during DBS because of large stimulation artifacts. Here, we report the observation of neuronal activities of the globus pallidus (GP) in normal and PD model rats during electrical stimulation of the STN. A custom artifact removal technique was devised to enable monitoring of neural activity during stimulation. We investigated how GP neurons responded to STN stimulation at various stimulation frequencies (10, 50, 90 and 130 Hz). It was observed that activities of GP neurons were modulated by stimulation frequency of the STN and significantly inhibited by high frequency stimulation above 50 Hz. These findings suggest that GP neuronal activity is effectively modulated by STN stimulation and strongly dependent on the frequency of stimulation.

Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalKorean Journal of Physiology and Pharmacology
Volume17
Issue number4
DOIs
Publication statusPublished - 2013 Aug 1

Fingerprint

Subthalamic Nucleus
Globus Pallidus
Electric Stimulation
Parkinson Disease
Deep Brain Stimulation
Therapeutic Uses
Basal Ganglia
Neurons
Artifacts
Dopaminergic Neurons
Observation

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology

Cite this

Ryu, Sang Baek ; Bae, Eun Kyung ; Kim, Jinhyung ; Hwang, Yong Sup ; Im, Changkyun ; Chang, Jin Woo ; Shin, Hyung Cheul ; Kim, Kyung Hwan. / N euronal responses in the globus pallidus during subthalamic nucleus electrical stimulation in normal and Parkinson's disease model rats. In: Korean Journal of Physiology and Pharmacology. 2013 ; Vol. 17, No. 4. pp. 299-306.
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N euronal responses in the globus pallidus during subthalamic nucleus electrical stimulation in normal and Parkinson's disease model rats. / Ryu, Sang Baek; Bae, Eun Kyung; Kim, Jinhyung; Hwang, Yong Sup; Im, Changkyun; Chang, Jin Woo; Shin, Hyung Cheul; Kim, Kyung Hwan.

In: Korean Journal of Physiology and Pharmacology, Vol. 17, No. 4, 01.08.2013, p. 299-306.

Research output: Contribution to journalArticle

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AU - Ryu, Sang Baek

AU - Bae, Eun Kyung

AU - Kim, Jinhyung

AU - Hwang, Yong Sup

AU - Im, Changkyun

AU - Chang, Jin Woo

AU - Shin, Hyung Cheul

AU - Kim, Kyung Hwan

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N2 - Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been widely used as a treatment for the movement disturbances caused by Parkinson's disease (PD). Despite successful application of DBS, its mechanism of therapeutic effect is not clearly understood. Because PD results from the degeneration of dopamine neurons that affect the basal ganglia (BG) network, investigation of neuronal responses of BG neurons during STN DBS can provide informative insights for the understanding of the mechanism of therapeutic effect. However, it is difficult to observe neuronal activity during DBS because of large stimulation artifacts. Here, we report the observation of neuronal activities of the globus pallidus (GP) in normal and PD model rats during electrical stimulation of the STN. A custom artifact removal technique was devised to enable monitoring of neural activity during stimulation. We investigated how GP neurons responded to STN stimulation at various stimulation frequencies (10, 50, 90 and 130 Hz). It was observed that activities of GP neurons were modulated by stimulation frequency of the STN and significantly inhibited by high frequency stimulation above 50 Hz. These findings suggest that GP neuronal activity is effectively modulated by STN stimulation and strongly dependent on the frequency of stimulation.

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