N-Hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide, a novel hydroxamic acid-based inhibitor of aminopeptidase N and its anti-angiogenic activity

Jiyong Lee, Joong Sup Shim, Sun Ah Jung, Seung-Taek Lee, Ho Jeong Kwon

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17 Citations (Scopus)

Abstract

The discovery of a structurally new inhibitor of aminopeptidase N and its anti-angiogenic activity are reported. In the course of our screening, N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide (1), which contains a metal-chelating hydroxamate group, has been identified as a potent inhibitor of aminopeptidase N (APN, EC 3.4.11.2). Compound 1 potently inhibited APN activity with a Ki value of 3.5 μM. It also inhibited the basic fibroblast growth-factor-induced invasion of bovine aortic endothelial cells at low micromolar concentrations.

Original languageEnglish
Pages (from-to)181-183
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number1
DOIs
Publication statusPublished - 2005 Jan 3

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Hydroxamic Acids
CD13 Antigens
Endothelial cells
Fibroblast Growth Factor 2
Chelation
Screening
Endothelial Cells
Metals
N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

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AU - Jung, Sun Ah

AU - Lee, Seung-Taek

AU - Kwon, Ho Jeong

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