N-Nicotinoyl dopamine, a novel niacinamide derivative, retains high antioxidant activity and inhibits skin pigmentation

Bora Kim, Jin Eun Kim, Su Min Lee, Soung Hoon Lee, Jin Won Lee, Myung Kyoo Kim, Kye Jong Lee, Hyuk Kim, Joo Dong Lee, Kang Yell Choi

Research output: Contribution to journalLetter

14 Citations (Scopus)


We synthesized a novel derivative of a well-known skin-lightening compound niacinamide, N-nicotinoyl dopamine (NND). NND did not show inhibitory effects of tyrosinase and melanin synthesis in B16F10 mouse melanoma cells. However, NND retains high antioxidant activity without affecting viability of cells. In a reconstructed skin model, topical applications of 0.05% and 0.1% NND induced skin lightening and decreased melanin production without affecting the viability and morphology of melanocytes and overall tissue histology. Moreover, no evidence for skin irritation or sensitization was observed when 0.1% NND emulsion was applied onto the skin of 52 volunteers. The effect of NND on skin lightening was further revealed by pigmented spot analyses of human clinical trial. Overall, NND treatment may be a useful trial for skin lightening and treating pigmentary disorders.

Original languageEnglish
Pages (from-to)950-952
Number of pages3
JournalExperimental dermatology
Issue number11
Publication statusPublished - 2011 Nov 1


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology

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