N-Nicotinoyl dopamine, a novel niacinamide derivative, retains high antioxidant activity and inhibits skin pigmentation

Bora Kim, Jin Eun Kim, Su Min Lee, Soung Hoon Lee, Jin Won Lee, Myung Kyoo Kim, Kye Jong Lee, Hyuk Kim, Joo Dong Lee, Kang-Yell Choi

Research output: Contribution to journalLetter

14 Citations (Scopus)

Abstract

We synthesized a novel derivative of a well-known skin-lightening compound niacinamide, N-nicotinoyl dopamine (NND). NND did not show inhibitory effects of tyrosinase and melanin synthesis in B16F10 mouse melanoma cells. However, NND retains high antioxidant activity without affecting viability of cells. In a reconstructed skin model, topical applications of 0.05% and 0.1% NND induced skin lightening and decreased melanin production without affecting the viability and morphology of melanocytes and overall tissue histology. Moreover, no evidence for skin irritation or sensitization was observed when 0.1% NND emulsion was applied onto the skin of 52 volunteers. The effect of NND on skin lightening was further revealed by pigmented spot analyses of human clinical trial. Overall, NND treatment may be a useful trial for skin lightening and treating pigmentary disorders.

Original languageEnglish
Pages (from-to)950-952
Number of pages3
JournalExperimental Dermatology
Volume20
Issue number11
DOIs
Publication statusPublished - 2011 Nov 1

Fingerprint

Skin Pigmentation
Niacinamide
Dopamine
Skin
Antioxidants
Derivatives
Melanins
Histology
Monophenol Monooxygenase
Melanocytes
N-nicotinoyl dopamine
Emulsions
Volunteers
Melanoma
Cell Survival
Cells
Clinical Trials
Tissue

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

Kim, Bora ; Kim, Jin Eun ; Lee, Su Min ; Lee, Soung Hoon ; Lee, Jin Won ; Kim, Myung Kyoo ; Lee, Kye Jong ; Kim, Hyuk ; Lee, Joo Dong ; Choi, Kang-Yell. / N-Nicotinoyl dopamine, a novel niacinamide derivative, retains high antioxidant activity and inhibits skin pigmentation. In: Experimental Dermatology. 2011 ; Vol. 20, No. 11. pp. 950-952.
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abstract = "We synthesized a novel derivative of a well-known skin-lightening compound niacinamide, N-nicotinoyl dopamine (NND). NND did not show inhibitory effects of tyrosinase and melanin synthesis in B16F10 mouse melanoma cells. However, NND retains high antioxidant activity without affecting viability of cells. In a reconstructed skin model, topical applications of 0.05{\%} and 0.1{\%} NND induced skin lightening and decreased melanin production without affecting the viability and morphology of melanocytes and overall tissue histology. Moreover, no evidence for skin irritation or sensitization was observed when 0.1{\%} NND emulsion was applied onto the skin of 52 volunteers. The effect of NND on skin lightening was further revealed by pigmented spot analyses of human clinical trial. Overall, NND treatment may be a useful trial for skin lightening and treating pigmentary disorders.",
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N-Nicotinoyl dopamine, a novel niacinamide derivative, retains high antioxidant activity and inhibits skin pigmentation. / Kim, Bora; Kim, Jin Eun; Lee, Su Min; Lee, Soung Hoon; Lee, Jin Won; Kim, Myung Kyoo; Lee, Kye Jong; Kim, Hyuk; Lee, Joo Dong; Choi, Kang-Yell.

In: Experimental Dermatology, Vol. 20, No. 11, 01.11.2011, p. 950-952.

Research output: Contribution to journalLetter

TY - JOUR

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AU - Kim, Bora

AU - Kim, Jin Eun

AU - Lee, Su Min

AU - Lee, Soung Hoon

AU - Lee, Jin Won

AU - Kim, Myung Kyoo

AU - Lee, Kye Jong

AU - Kim, Hyuk

AU - Lee, Joo Dong

AU - Choi, Kang-Yell

PY - 2011/11/1

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N2 - We synthesized a novel derivative of a well-known skin-lightening compound niacinamide, N-nicotinoyl dopamine (NND). NND did not show inhibitory effects of tyrosinase and melanin synthesis in B16F10 mouse melanoma cells. However, NND retains high antioxidant activity without affecting viability of cells. In a reconstructed skin model, topical applications of 0.05% and 0.1% NND induced skin lightening and decreased melanin production without affecting the viability and morphology of melanocytes and overall tissue histology. Moreover, no evidence for skin irritation or sensitization was observed when 0.1% NND emulsion was applied onto the skin of 52 volunteers. The effect of NND on skin lightening was further revealed by pigmented spot analyses of human clinical trial. Overall, NND treatment may be a useful trial for skin lightening and treating pigmentary disorders.

AB - We synthesized a novel derivative of a well-known skin-lightening compound niacinamide, N-nicotinoyl dopamine (NND). NND did not show inhibitory effects of tyrosinase and melanin synthesis in B16F10 mouse melanoma cells. However, NND retains high antioxidant activity without affecting viability of cells. In a reconstructed skin model, topical applications of 0.05% and 0.1% NND induced skin lightening and decreased melanin production without affecting the viability and morphology of melanocytes and overall tissue histology. Moreover, no evidence for skin irritation or sensitization was observed when 0.1% NND emulsion was applied onto the skin of 52 volunteers. The effect of NND on skin lightening was further revealed by pigmented spot analyses of human clinical trial. Overall, NND treatment may be a useful trial for skin lightening and treating pigmentary disorders.

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