N-terminal pro-B-type natriuretic peptide and cardiac troponin T in non-immune hydrops

Seung Mi Lee, Jong Kwan Jun, Su Ah Kim, Min Ji Kang, Sang Hoon Song, Joon Ho Lee, Chan Wook Park, Joong Shin Park

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aim We analyzed the N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in non-immune hydrops cases, to determine whether congestive heart failure or inadequate cardiac output may be mechanisms underlying abnormal fluid collection in hydrops. Methods The study population consisted of singleton neonates with non-immune hydrops and healthy control neonates, matched for both gestational age at delivery and mode of delivery. The subjects were divided into three groups: group 1, hydrops of cardiac origin (n=6); group 2, hydrops of non-cardiac origin (n=17); and group 3, control (n=23). The NT-proBNP and cTnT were measured in the cord blood collected at the time of delivery. Results The median cord blood concentrations of NT-proBNP and cTnT were not different between the hydrops (groups 1 and 2) or control cases. However, the NT-proBNP level was elevated in group 1 compared with groups 2 and 3. The concentrations of cTnT did not differ among the three groups. Conclusions The concentration of NT-proBNP was only elevated in cases of hydrops of cardiac origin. Congestive heart failure might not be the underlying mechanism of fluid collection in cases of non-immune hydrops of non-cardiac origin, and NT-proBNP may be a promising tool to differentiate the origin of hydrops.

Original languageEnglish
Pages (from-to)380-384
Number of pages5
JournalJournal of Obstetrics and Gynaecology Research
Volume42
Issue number4
DOIs
Publication statusPublished - 2016 Apr 1

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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