N-terminal pro-B-type natriuretic peptide and cardiac troponin T in non-immune hydrops

Seung Mi Lee, Jong Kwan Jun, Su Ah Kim, Min Ji Kang, Sang Hoon Song, Joon Ho Lee, Chan Wook Park, Joong Shin Park

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim We analyzed the N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in non-immune hydrops cases, to determine whether congestive heart failure or inadequate cardiac output may be mechanisms underlying abnormal fluid collection in hydrops. Methods The study population consisted of singleton neonates with non-immune hydrops and healthy control neonates, matched for both gestational age at delivery and mode of delivery. The subjects were divided into three groups: group 1, hydrops of cardiac origin (n=6); group 2, hydrops of non-cardiac origin (n=17); and group 3, control (n=23). The NT-proBNP and cTnT were measured in the cord blood collected at the time of delivery. Results The median cord blood concentrations of NT-proBNP and cTnT were not different between the hydrops (groups 1 and 2) or control cases. However, the NT-proBNP level was elevated in group 1 compared with groups 2 and 3. The concentrations of cTnT did not differ among the three groups. Conclusions The concentration of NT-proBNP was only elevated in cases of hydrops of cardiac origin. Congestive heart failure might not be the underlying mechanism of fluid collection in cases of non-immune hydrops of non-cardiac origin, and NT-proBNP may be a promising tool to differentiate the origin of hydrops.

Original languageEnglish
Pages (from-to)380-384
Number of pages5
JournalJournal of Obstetrics and Gynaecology Research
Volume42
Issue number4
DOIs
Publication statusPublished - 2016 Apr 1

Fingerprint

Troponin T
Brain Natriuretic Peptide
Edema
Fetal Blood
Heart Failure
Cardiac Output
Gestational Age
Control Groups

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Lee, Seung Mi ; Jun, Jong Kwan ; Kim, Su Ah ; Kang, Min Ji ; Song, Sang Hoon ; Lee, Joon Ho ; Park, Chan Wook ; Park, Joong Shin. / N-terminal pro-B-type natriuretic peptide and cardiac troponin T in non-immune hydrops. In: Journal of Obstetrics and Gynaecology Research. 2016 ; Vol. 42, No. 4. pp. 380-384.
@article{b512247ee24a4159a2f4f58efb543574,
title = "N-terminal pro-B-type natriuretic peptide and cardiac troponin T in non-immune hydrops",
abstract = "Aim We analyzed the N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in non-immune hydrops cases, to determine whether congestive heart failure or inadequate cardiac output may be mechanisms underlying abnormal fluid collection in hydrops. Methods The study population consisted of singleton neonates with non-immune hydrops and healthy control neonates, matched for both gestational age at delivery and mode of delivery. The subjects were divided into three groups: group 1, hydrops of cardiac origin (n=6); group 2, hydrops of non-cardiac origin (n=17); and group 3, control (n=23). The NT-proBNP and cTnT were measured in the cord blood collected at the time of delivery. Results The median cord blood concentrations of NT-proBNP and cTnT were not different between the hydrops (groups 1 and 2) or control cases. However, the NT-proBNP level was elevated in group 1 compared with groups 2 and 3. The concentrations of cTnT did not differ among the three groups. Conclusions The concentration of NT-proBNP was only elevated in cases of hydrops of cardiac origin. Congestive heart failure might not be the underlying mechanism of fluid collection in cases of non-immune hydrops of non-cardiac origin, and NT-proBNP may be a promising tool to differentiate the origin of hydrops.",
author = "Lee, {Seung Mi} and Jun, {Jong Kwan} and Kim, {Su Ah} and Kang, {Min Ji} and Song, {Sang Hoon} and Lee, {Joon Ho} and Park, {Chan Wook} and Park, {Joong Shin}",
year = "2016",
month = "4",
day = "1",
doi = "10.1111/jog.12920",
language = "English",
volume = "42",
pages = "380--384",
journal = "Journal of Obstetrics and Gynaecology Research",
issn = "1341-8076",
publisher = "Blackwell Publishing Asia",
number = "4",

}

N-terminal pro-B-type natriuretic peptide and cardiac troponin T in non-immune hydrops. / Lee, Seung Mi; Jun, Jong Kwan; Kim, Su Ah; Kang, Min Ji; Song, Sang Hoon; Lee, Joon Ho; Park, Chan Wook; Park, Joong Shin.

In: Journal of Obstetrics and Gynaecology Research, Vol. 42, No. 4, 01.04.2016, p. 380-384.

Research output: Contribution to journalArticle

TY - JOUR

T1 - N-terminal pro-B-type natriuretic peptide and cardiac troponin T in non-immune hydrops

AU - Lee, Seung Mi

AU - Jun, Jong Kwan

AU - Kim, Su Ah

AU - Kang, Min Ji

AU - Song, Sang Hoon

AU - Lee, Joon Ho

AU - Park, Chan Wook

AU - Park, Joong Shin

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Aim We analyzed the N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in non-immune hydrops cases, to determine whether congestive heart failure or inadequate cardiac output may be mechanisms underlying abnormal fluid collection in hydrops. Methods The study population consisted of singleton neonates with non-immune hydrops and healthy control neonates, matched for both gestational age at delivery and mode of delivery. The subjects were divided into three groups: group 1, hydrops of cardiac origin (n=6); group 2, hydrops of non-cardiac origin (n=17); and group 3, control (n=23). The NT-proBNP and cTnT were measured in the cord blood collected at the time of delivery. Results The median cord blood concentrations of NT-proBNP and cTnT were not different between the hydrops (groups 1 and 2) or control cases. However, the NT-proBNP level was elevated in group 1 compared with groups 2 and 3. The concentrations of cTnT did not differ among the three groups. Conclusions The concentration of NT-proBNP was only elevated in cases of hydrops of cardiac origin. Congestive heart failure might not be the underlying mechanism of fluid collection in cases of non-immune hydrops of non-cardiac origin, and NT-proBNP may be a promising tool to differentiate the origin of hydrops.

AB - Aim We analyzed the N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in non-immune hydrops cases, to determine whether congestive heart failure or inadequate cardiac output may be mechanisms underlying abnormal fluid collection in hydrops. Methods The study population consisted of singleton neonates with non-immune hydrops and healthy control neonates, matched for both gestational age at delivery and mode of delivery. The subjects were divided into three groups: group 1, hydrops of cardiac origin (n=6); group 2, hydrops of non-cardiac origin (n=17); and group 3, control (n=23). The NT-proBNP and cTnT were measured in the cord blood collected at the time of delivery. Results The median cord blood concentrations of NT-proBNP and cTnT were not different between the hydrops (groups 1 and 2) or control cases. However, the NT-proBNP level was elevated in group 1 compared with groups 2 and 3. The concentrations of cTnT did not differ among the three groups. Conclusions The concentration of NT-proBNP was only elevated in cases of hydrops of cardiac origin. Congestive heart failure might not be the underlying mechanism of fluid collection in cases of non-immune hydrops of non-cardiac origin, and NT-proBNP may be a promising tool to differentiate the origin of hydrops.

UR - http://www.scopus.com/inward/record.url?scp=84955118502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955118502&partnerID=8YFLogxK

U2 - 10.1111/jog.12920

DO - 10.1111/jog.12920

M3 - Article

C2 - 26787625

AN - SCOPUS:84955118502

VL - 42

SP - 380

EP - 384

JO - Journal of Obstetrics and Gynaecology Research

JF - Journal of Obstetrics and Gynaecology Research

SN - 1341-8076

IS - 4

ER -