N-terminal pro-B-type natriuretic peptide is associated with adverse short-term clinical outcomes in patients with acute ST-elevation myocardial infarction underwent primary percutaneous coronary intervention

Taek Geun Kwon, Jang Ho Bae, Myung Ho Jeong, Young Jo Kim, Seung Ho Hur, In Whan Seong, Myeong Chan Cho, Ki Bae Seung, Yangsoo Jang, Seung Jung Park

Research output: Contribution to journalArticle

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Abstract

Background: Increased level of N-terminal pro-B type natriuretic peptide (NT-proBNP) is known to be associated with adverse outcome in patients with acute coronary syndrome. We evaluated early outcomes of patients with acute ST-elevated myocardial infarction (STEMI) according to the level of NT-proBNP as a substudy of Korean Acute Myocardial Infarction Registry (KAMIR). Methods: Study population consisted of 1052 consecutive patients (mean 61.3 ± 12.8 years old, male 73.2%) with STEMI of onset < 12 h who underwent primary percutaneous coronary intervention (PCI) and who had baseline NT-proBNP level by electrochemiluminescence immnunoassay (ECLIA, NT-proBNP kit, Roche Diagnostics, Mannheim, Germany). The study subjects were divided into two groups according to the level of serum NT-proBNP. Results: Patients with NT-proBNP level > 991 pg/mL (n = 329, 57.1% male) had lower left ventricle ejection fraction (LVEF) (47.8 ± 11.8% vs. 53.0 ± 10.8%, p < 0.001), needed longer intensive care (3.7 ± 3.6 days vs. 2.8 ± 2.4 days, p < 0.001) and had higher in-hospital mortality (1.3% vs. 7.4%, p < 0.001) than those with NT-proBNP level ≤ 991 pg/mL (n = 723, 80.5% male). Multiple logistic regression analysis revealed that the independent predictors of in-hospital mortality were LVEF < 45% (OR 5.43, 95% CI 1.71 to 17.29, p = 0.004), elevated NT-proBNP (> 991 pg/mL) (OR 3.70, 95% CI 1.14 to 12.03, p = 0.030), old age (≥ 70 years) (OR 4.71, 95% CI 1.43 to 15.52, p = 0.011), advanced Killip class (> 1) (OR 4.96, 95% CI 1.58 to 15.53, p = 0.006), male gender (OR 5.67, 95% CI 1.45 to 22.21, p = 0.013) and TIMI flow 0 before PCI (OR 5.04, 95% CI 1.08 to 23.41, p = 0.039). Conclusions: This study suggests that baseline NT-proBNP level is associated with short term mortality in patients with STEMI underwent primary PCI.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalInternational Journal of Cardiology
Volume133
Issue number2
DOIs
Publication statusPublished - 2009 Apr 3

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Brain Natriuretic Peptide
Percutaneous Coronary Intervention
Acute Coronary Syndrome
Heart Ventricles
Registries
Myocardial Infarction
Mortality
ST Elevation Myocardial Infarction
Population

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Kwon, Taek Geun ; Bae, Jang Ho ; Jeong, Myung Ho ; Kim, Young Jo ; Hur, Seung Ho ; Seong, In Whan ; Cho, Myeong Chan ; Seung, Ki Bae ; Jang, Yangsoo ; Park, Seung Jung. / N-terminal pro-B-type natriuretic peptide is associated with adverse short-term clinical outcomes in patients with acute ST-elevation myocardial infarction underwent primary percutaneous coronary intervention. In: International Journal of Cardiology. 2009 ; Vol. 133, No. 2. pp. 173-178.
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title = "N-terminal pro-B-type natriuretic peptide is associated with adverse short-term clinical outcomes in patients with acute ST-elevation myocardial infarction underwent primary percutaneous coronary intervention",
abstract = "Background: Increased level of N-terminal pro-B type natriuretic peptide (NT-proBNP) is known to be associated with adverse outcome in patients with acute coronary syndrome. We evaluated early outcomes of patients with acute ST-elevated myocardial infarction (STEMI) according to the level of NT-proBNP as a substudy of Korean Acute Myocardial Infarction Registry (KAMIR). Methods: Study population consisted of 1052 consecutive patients (mean 61.3 ± 12.8 years old, male 73.2{\%}) with STEMI of onset < 12 h who underwent primary percutaneous coronary intervention (PCI) and who had baseline NT-proBNP level by electrochemiluminescence immnunoassay (ECLIA, NT-proBNP kit, Roche Diagnostics, Mannheim, Germany). The study subjects were divided into two groups according to the level of serum NT-proBNP. Results: Patients with NT-proBNP level > 991 pg/mL (n = 329, 57.1{\%} male) had lower left ventricle ejection fraction (LVEF) (47.8 ± 11.8{\%} vs. 53.0 ± 10.8{\%}, p < 0.001), needed longer intensive care (3.7 ± 3.6 days vs. 2.8 ± 2.4 days, p < 0.001) and had higher in-hospital mortality (1.3{\%} vs. 7.4{\%}, p < 0.001) than those with NT-proBNP level ≤ 991 pg/mL (n = 723, 80.5{\%} male). Multiple logistic regression analysis revealed that the independent predictors of in-hospital mortality were LVEF < 45{\%} (OR 5.43, 95{\%} CI 1.71 to 17.29, p = 0.004), elevated NT-proBNP (> 991 pg/mL) (OR 3.70, 95{\%} CI 1.14 to 12.03, p = 0.030), old age (≥ 70 years) (OR 4.71, 95{\%} CI 1.43 to 15.52, p = 0.011), advanced Killip class (> 1) (OR 4.96, 95{\%} CI 1.58 to 15.53, p = 0.006), male gender (OR 5.67, 95{\%} CI 1.45 to 22.21, p = 0.013) and TIMI flow 0 before PCI (OR 5.04, 95{\%} CI 1.08 to 23.41, p = 0.039). Conclusions: This study suggests that baseline NT-proBNP level is associated with short term mortality in patients with STEMI underwent primary PCI.",
author = "Kwon, {Taek Geun} and Bae, {Jang Ho} and Jeong, {Myung Ho} and Kim, {Young Jo} and Hur, {Seung Ho} and Seong, {In Whan} and Cho, {Myeong Chan} and Seung, {Ki Bae} and Yangsoo Jang and Park, {Seung Jung}",
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N-terminal pro-B-type natriuretic peptide is associated with adverse short-term clinical outcomes in patients with acute ST-elevation myocardial infarction underwent primary percutaneous coronary intervention. / Kwon, Taek Geun; Bae, Jang Ho; Jeong, Myung Ho; Kim, Young Jo; Hur, Seung Ho; Seong, In Whan; Cho, Myeong Chan; Seung, Ki Bae; Jang, Yangsoo; Park, Seung Jung.

In: International Journal of Cardiology, Vol. 133, No. 2, 03.04.2009, p. 173-178.

Research output: Contribution to journalArticle

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T1 - N-terminal pro-B-type natriuretic peptide is associated with adverse short-term clinical outcomes in patients with acute ST-elevation myocardial infarction underwent primary percutaneous coronary intervention

AU - Kwon, Taek Geun

AU - Bae, Jang Ho

AU - Jeong, Myung Ho

AU - Kim, Young Jo

AU - Hur, Seung Ho

AU - Seong, In Whan

AU - Cho, Myeong Chan

AU - Seung, Ki Bae

AU - Jang, Yangsoo

AU - Park, Seung Jung

PY - 2009/4/3

Y1 - 2009/4/3

N2 - Background: Increased level of N-terminal pro-B type natriuretic peptide (NT-proBNP) is known to be associated with adverse outcome in patients with acute coronary syndrome. We evaluated early outcomes of patients with acute ST-elevated myocardial infarction (STEMI) according to the level of NT-proBNP as a substudy of Korean Acute Myocardial Infarction Registry (KAMIR). Methods: Study population consisted of 1052 consecutive patients (mean 61.3 ± 12.8 years old, male 73.2%) with STEMI of onset < 12 h who underwent primary percutaneous coronary intervention (PCI) and who had baseline NT-proBNP level by electrochemiluminescence immnunoassay (ECLIA, NT-proBNP kit, Roche Diagnostics, Mannheim, Germany). The study subjects were divided into two groups according to the level of serum NT-proBNP. Results: Patients with NT-proBNP level > 991 pg/mL (n = 329, 57.1% male) had lower left ventricle ejection fraction (LVEF) (47.8 ± 11.8% vs. 53.0 ± 10.8%, p < 0.001), needed longer intensive care (3.7 ± 3.6 days vs. 2.8 ± 2.4 days, p < 0.001) and had higher in-hospital mortality (1.3% vs. 7.4%, p < 0.001) than those with NT-proBNP level ≤ 991 pg/mL (n = 723, 80.5% male). Multiple logistic regression analysis revealed that the independent predictors of in-hospital mortality were LVEF < 45% (OR 5.43, 95% CI 1.71 to 17.29, p = 0.004), elevated NT-proBNP (> 991 pg/mL) (OR 3.70, 95% CI 1.14 to 12.03, p = 0.030), old age (≥ 70 years) (OR 4.71, 95% CI 1.43 to 15.52, p = 0.011), advanced Killip class (> 1) (OR 4.96, 95% CI 1.58 to 15.53, p = 0.006), male gender (OR 5.67, 95% CI 1.45 to 22.21, p = 0.013) and TIMI flow 0 before PCI (OR 5.04, 95% CI 1.08 to 23.41, p = 0.039). Conclusions: This study suggests that baseline NT-proBNP level is associated with short term mortality in patients with STEMI underwent primary PCI.

AB - Background: Increased level of N-terminal pro-B type natriuretic peptide (NT-proBNP) is known to be associated with adverse outcome in patients with acute coronary syndrome. We evaluated early outcomes of patients with acute ST-elevated myocardial infarction (STEMI) according to the level of NT-proBNP as a substudy of Korean Acute Myocardial Infarction Registry (KAMIR). Methods: Study population consisted of 1052 consecutive patients (mean 61.3 ± 12.8 years old, male 73.2%) with STEMI of onset < 12 h who underwent primary percutaneous coronary intervention (PCI) and who had baseline NT-proBNP level by electrochemiluminescence immnunoassay (ECLIA, NT-proBNP kit, Roche Diagnostics, Mannheim, Germany). The study subjects were divided into two groups according to the level of serum NT-proBNP. Results: Patients with NT-proBNP level > 991 pg/mL (n = 329, 57.1% male) had lower left ventricle ejection fraction (LVEF) (47.8 ± 11.8% vs. 53.0 ± 10.8%, p < 0.001), needed longer intensive care (3.7 ± 3.6 days vs. 2.8 ± 2.4 days, p < 0.001) and had higher in-hospital mortality (1.3% vs. 7.4%, p < 0.001) than those with NT-proBNP level ≤ 991 pg/mL (n = 723, 80.5% male). Multiple logistic regression analysis revealed that the independent predictors of in-hospital mortality were LVEF < 45% (OR 5.43, 95% CI 1.71 to 17.29, p = 0.004), elevated NT-proBNP (> 991 pg/mL) (OR 3.70, 95% CI 1.14 to 12.03, p = 0.030), old age (≥ 70 years) (OR 4.71, 95% CI 1.43 to 15.52, p = 0.011), advanced Killip class (> 1) (OR 4.96, 95% CI 1.58 to 15.53, p = 0.006), male gender (OR 5.67, 95% CI 1.45 to 22.21, p = 0.013) and TIMI flow 0 before PCI (OR 5.04, 95% CI 1.08 to 23.41, p = 0.039). Conclusions: This study suggests that baseline NT-proBNP level is associated with short term mortality in patients with STEMI underwent primary PCI.

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