N-terminal pro-brain natriuretic peptide (NT-proBNP) in Type 2 diabetes with left ventricular dysfunction

Ji Youn Kim, Eun Young Lee, Jae Hwan Jee, Byung Wan Lee, Jae Hoon Chung, Eun Suk Jeun, Yong Ki Min, Myung Shik Lee, Kwang Won Kim, Moon Kyu Lee

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Abstract

Plasma N-terminal proBNP (NT-proBNP) is released in response to pressure overload, intravascular volume expansion and myocardial ischemia from cardiac ventricles. We studied the relationship between NT-proBNP levels and left ventricular dysfunction and urinary albumin excretion in Type 2 diabetes. The study group consisted of 130 diabetic patients referred for echocardiography. They were divided into four groups according to echocardiographic finding and into three groups according to urinary albumin excretion. NT-proBNP levels were measured by electrochemiluminescence. There were significant differences in NT-proBNP levels among four groups (P = 0.012), with a highly significant difference between normal and other groups with left ventricular dysfunction. NT-proBNP levels in diastolic dysfunction were significantly higher than normal group (1491.1 pg/mL versus 232.3 pg/mL, P = 0.01), even though there was no difference in ejection fraction (EF) (61.2 ± 7.9% versus 60 ± 8.4%, P = 0.773). NT-proBNP levels showed positive correlation with age (Rs = 0.37, P < 0.001), creatinine (Rs = 0.38, P = 0.001), LVIDS (Rs = 0.56, P = 0.001) and LVIDD (Rs = 0.34, P = 0.04) and negative correlation with EF (Rs = -0.66, P = 0.001). NT-proBNP levels significantly differed among three groups according to urinary albumin excretion (P = 0.031). These results suggest that NT-proBNP could be used to identify any impairment of left ventricular function in diabetes.

Original languageEnglish
Pages (from-to)S238-S242
JournalDiabetes Research and Clinical Practice
Volume77
Issue number3 SUPPL.
DOIs
Publication statusPublished - 2007 Sep 1

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All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Kim, J. Y., Lee, E. Y., Jee, J. H., Lee, B. W., Chung, J. H., Jeun, E. S., Min, Y. K., Lee, M. S., Kim, K. W., & Lee, M. K. (2007). N-terminal pro-brain natriuretic peptide (NT-proBNP) in Type 2 diabetes with left ventricular dysfunction. Diabetes Research and Clinical Practice, 77(3 SUPPL.), S238-S242. https://doi.org/10.1016/j.diabres.2007.01.064