Hydrogels have been mainly used for biomedical applications owing to their biocompatibility and high water content. However, they have serious limitations such as poor mechanical stability and fast release of the incorporated drug. To overcome these problems, we prepared collagen hydrogel (Col-H) with layer-by-layer (LbL) self-assembled films (Col-H) to develop multifunctional hydrogel. We prepared LbL films using tannic acid and lignin for multi-functional properties. In addition, we incorporated doxorubicin as a model drug, which is widely used for cancer therapy. Furthermore, the prepared films exhibit antibacterial effect against gram-positive and negative bacteria and endure higher compression stress than bare Col-H.
Bibliographical noteFunding Information:
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation of Korea (NRF) funded by the Korean Government (Grant 2012M3A9C6050104 ) and supported by the National Research Foundation of Korea (NRF), funded by the Korean Government Ministry of Science, ICT & Future Planning (Grant 2013R1A1A1076126 ). Additionally, this research was also supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (Grant HI14C-3266 , HI15C-1653 ). This work was also carried out with the support of “ Cooperative Research Program for Agriculture Science & Technology Development (Grant PJ00998601 )” Rural Development Administration, Republic of Korea. Additionally Jinkee Hong appreciate to Dr. Kahee Kwon for thoughtful help for this research.
© 2016 The Korean Society of Industrial and Engineering Chemistry.
All Science Journal Classification (ASJC) codes
- Chemical Engineering(all)