Nano-film coatings onto collagen hydrogels with desired drug release

Daheui Choi, Jiwoong Heo, Joo Hee Park, Yeonho Jo, Hyejoong Jeong, Minwook Chang, Jonghoon Choi, Jinkee Hong

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Hydrogels have been mainly used for biomedical applications owing to their biocompatibility and high water content. However, they have serious limitations such as poor mechanical stability and fast release of the incorporated drug. To overcome these problems, we prepared collagen hydrogel (Col-H) with layer-by-layer (LbL) self-assembled films (Col-H) to develop multifunctional hydrogel. We prepared LbL films using tannic acid and lignin for multi-functional properties. In addition, we incorporated doxorubicin as a model drug, which is widely used for cancer therapy. Furthermore, the prepared films exhibit antibacterial effect against gram-positive and negative bacteria and endure higher compression stress than bare Col-H.

Original languageEnglish
Pages (from-to)326-333
Number of pages8
JournalJournal of Industrial and Engineering Chemistry
Volume36
DOIs
Publication statusPublished - 2016 Apr 25

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Hydrogels
Hydrogel
Collagen
Coatings
Pharmaceutical Preparations
Mechanical stability
Lignin
Tannins
Biocompatibility
Doxorubicin
Water content
Bacteria
Acids

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)

Cite this

Choi, Daheui ; Heo, Jiwoong ; Park, Joo Hee ; Jo, Yeonho ; Jeong, Hyejoong ; Chang, Minwook ; Choi, Jonghoon ; Hong, Jinkee. / Nano-film coatings onto collagen hydrogels with desired drug release. In: Journal of Industrial and Engineering Chemistry. 2016 ; Vol. 36. pp. 326-333.
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Nano-film coatings onto collagen hydrogels with desired drug release. / Choi, Daheui; Heo, Jiwoong; Park, Joo Hee; Jo, Yeonho; Jeong, Hyejoong; Chang, Minwook; Choi, Jonghoon; Hong, Jinkee.

In: Journal of Industrial and Engineering Chemistry, Vol. 36, 25.04.2016, p. 326-333.

Research output: Contribution to journalArticle

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AU - Choi, Jonghoon

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