Nanoarchitectured peroxidase-mimetic nanozymes: Mesoporous nanocrystalline α- Or γ-iron oxide?

Mostafa Kamal Masud; Jeonghun Kim; Md Motasim Billah; Kathleen Wood; Mohammad J.A. Shiddiky; Nam Trung Nguyen; Rajesh Kumar Parsapur; Yusuf Valentino Kaneti; Abdulmohsen Ali Alshehri; Yousef Gamaan Alghamidi; Khalid Ahmed Alzahrani; Murugulla Adharvanachari; Parasuraman Selvam; Md Shahriar A. Hossain; Yusuke Yamauchi

doi:10.1039/c9tb00989b

Nanoarchitectured peroxidase-mimetic nanozymes: Mesoporous nanocrystalline α- Or γ-iron oxide?

Mostafa Kamal Masud, Jeonghun Kim, Md Motasim Billah, Kathleen Wood, Mohammad J.A. Shiddiky, Nam Trung Nguyen, Rajesh Kumar Parsapur, Yusuf Valentino Kaneti, Abdulmohsen Ali Alshehri, Yousef Gamaan Alghamidi, Khalid Ahmed Alzahrani, Murugulla Adharvanachari, Parasuraman Selvam, Md Shahriar A. Hossain, Yusuke Yamauchi

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Nanozymes (nanoparticles with enzyme-like properties) have attracted considerable attention in recent years owing to their intrinsic enzyme-like properties and broad application in the fields of ELISA based immunoassay and biosensing. Herein, we systematically investigate the influence of crystal phases (γ-Fe₂O₃ and α-Fe₂O₃) of mesoporous iron oxide (IO) on their peroxidase mimetic activity. In addition, we have also demonstrated the applicability of these mesoporous IOs as nanozymes for detecting the glucose biomarker with a limit of detection (LOD) of 0.9 μM. Mesoporous γ-Fe₂O₃ shows high nanozyme activities (and magnetism) toward the catalytic oxidation of chromogenic substances, such as 3,3′,5,5′-tetramethylbenzidine (TMB) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)-ABTS, as well as for the colourimetric detection of glucose, compared to that of α-Fe₂O₃. We believe that this in-depth study of crystal structure based nanozyme activity will guide designing highly effective nanozymes based on iron oxide nanostructures for chemical sensing, biosensing and environmental remediation.

Original language	English
Pages (from-to)	5412-5422
Number of pages	11
Journal	Journal of Materials Chemistry B
Volume	7
Issue number	35
DOIs	https://doi.org/10.1039/c9tb00989b
Publication status	Published - 2019

Bibliographical note

Funding Information:
This work was supported by the Australian Research Council (ARC) Discovery Project (DP190102944). This work was partially supported by the Australian Research Council (ARC) Future Fellow (FT150100479) to Y. Y., and Australian Government Research Training Program (RTP) Scholarship (the University of Queensland) to M. K. M. M. K. M. would also like to thank AINSE Limited for providing financial assistance (AINSE PGRA Award 2018). This work was partially performed at the Queensland node of the Australian National Fabrication Facility, a company established under the National Collaborative Research Infrastructure Strategy to provide nano-and micro-fabrication facilities for Australian researchers. The authors acknowledge the Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, for technical and financial support.

Publisher Copyright:
© 2019 The Royal Society of Chemistry.

All Science Journal Classification (ASJC) codes

Chemistry(all)
Biomedical Engineering
Materials Science(all)

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10.1039/c9tb00989b

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Masud, M. K., Kim, J., Billah, M. M., Wood, K., Shiddiky, M. J. A., Nguyen, N. T., Parsapur, R. K., Kaneti, Y. V., Alshehri, A. A., Alghamidi, Y. G., Alzahrani, K. A., Adharvanachari, M., Selvam, P., Hossain, M. S. A., & Yamauchi, Y. (2019). Nanoarchitectured peroxidase-mimetic nanozymes: Mesoporous nanocrystalline α- Or γ-iron oxide? Journal of Materials Chemistry B, 7(35), 5412-5422. https://doi.org/10.1039/c9tb00989b

@article{77ecaf9de94a41c4980177ae04dbd665,

title = "Nanoarchitectured peroxidase-mimetic nanozymes: Mesoporous nanocrystalline α- Or γ-iron oxide?",

abstract = "Nanozymes (nanoparticles with enzyme-like properties) have attracted considerable attention in recent years owing to their intrinsic enzyme-like properties and broad application in the fields of ELISA based immunoassay and biosensing. Herein, we systematically investigate the influence of crystal phases (γ-Fe2O3 and α-Fe2O3) of mesoporous iron oxide (IO) on their peroxidase mimetic activity. In addition, we have also demonstrated the applicability of these mesoporous IOs as nanozymes for detecting the glucose biomarker with a limit of detection (LOD) of 0.9 μM. Mesoporous γ-Fe2O3 shows high nanozyme activities (and magnetism) toward the catalytic oxidation of chromogenic substances, such as 3,3′,5,5′-tetramethylbenzidine (TMB) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)-ABTS, as well as for the colourimetric detection of glucose, compared to that of α-Fe2O3. We believe that this in-depth study of crystal structure based nanozyme activity will guide designing highly effective nanozymes based on iron oxide nanostructures for chemical sensing, biosensing and environmental remediation.",

author = "Masud, {Mostafa Kamal} and Jeonghun Kim and Billah, {Md Motasim} and Kathleen Wood and Shiddiky, {Mohammad J.A.} and Nguyen, {Nam Trung} and Parsapur, {Rajesh Kumar} and Kaneti, {Yusuf Valentino} and Alshehri, {Abdulmohsen Ali} and Alghamidi, {Yousef Gamaan} and Alzahrani, {Khalid Ahmed} and Murugulla Adharvanachari and Parasuraman Selvam and Hossain, {Md Shahriar A.} and Yusuke Yamauchi",

note = "Funding Information: This work was supported by the Australian Research Council (ARC) Discovery Project (DP190102944). This work was partially supported by the Australian Research Council (ARC) Future Fellow (FT150100479) to Y. Y., and Australian Government Research Training Program (RTP) Scholarship (the University of Queensland) to M. K. M. M. K. M. would also like to thank AINSE Limited for providing financial assistance (AINSE PGRA Award 2018). This work was partially performed at the Queensland node of the Australian National Fabrication Facility, a company established under the National Collaborative Research Infrastructure Strategy to provide nano-and micro-fabrication facilities for Australian researchers. The authors acknowledge the Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, for technical and financial support. Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

year = "2019",

doi = "10.1039/c9tb00989b",

language = "English",

volume = "7",

pages = "5412--5422",

journal = "Journal of Materials Chemistry B",

issn = "2050-7518",

publisher = "Royal Society of Chemistry",

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}

Masud, MK, Kim, J, Billah, MM, Wood, K, Shiddiky, MJA, Nguyen, NT, Parsapur, RK, Kaneti, YV, Alshehri, AA, Alghamidi, YG, Alzahrani, KA, Adharvanachari, M, Selvam, P, Hossain, MSA & Yamauchi, Y 2019, 'Nanoarchitectured peroxidase-mimetic nanozymes: Mesoporous nanocrystalline α- Or γ-iron oxide?', Journal of Materials Chemistry B, vol. 7, no. 35, pp. 5412-5422. https://doi.org/10.1039/c9tb00989b

TY - JOUR

T1 - Nanoarchitectured peroxidase-mimetic nanozymes

T2 - Mesoporous nanocrystalline α- Or γ-iron oxide?

AU - Masud, Mostafa Kamal

AU - Kim, Jeonghun

AU - Billah, Md Motasim

AU - Wood, Kathleen

AU - Shiddiky, Mohammad J.A.

AU - Nguyen, Nam Trung

AU - Parsapur, Rajesh Kumar

AU - Kaneti, Yusuf Valentino

AU - Alshehri, Abdulmohsen Ali

AU - Alghamidi, Yousef Gamaan

AU - Alzahrani, Khalid Ahmed

AU - Adharvanachari, Murugulla

AU - Selvam, Parasuraman

AU - Hossain, Md Shahriar A.

AU - Yamauchi, Yusuke

N1 - Funding Information: This work was supported by the Australian Research Council (ARC) Discovery Project (DP190102944). This work was partially supported by the Australian Research Council (ARC) Future Fellow (FT150100479) to Y. Y., and Australian Government Research Training Program (RTP) Scholarship (the University of Queensland) to M. K. M. M. K. M. would also like to thank AINSE Limited for providing financial assistance (AINSE PGRA Award 2018). This work was partially performed at the Queensland node of the Australian National Fabrication Facility, a company established under the National Collaborative Research Infrastructure Strategy to provide nano-and micro-fabrication facilities for Australian researchers. The authors acknowledge the Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, for technical and financial support. Publisher Copyright: © 2019 The Royal Society of Chemistry.

PY - 2019

Y1 - 2019

N2 - Nanozymes (nanoparticles with enzyme-like properties) have attracted considerable attention in recent years owing to their intrinsic enzyme-like properties and broad application in the fields of ELISA based immunoassay and biosensing. Herein, we systematically investigate the influence of crystal phases (γ-Fe2O3 and α-Fe2O3) of mesoporous iron oxide (IO) on their peroxidase mimetic activity. In addition, we have also demonstrated the applicability of these mesoporous IOs as nanozymes for detecting the glucose biomarker with a limit of detection (LOD) of 0.9 μM. Mesoporous γ-Fe2O3 shows high nanozyme activities (and magnetism) toward the catalytic oxidation of chromogenic substances, such as 3,3′,5,5′-tetramethylbenzidine (TMB) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)-ABTS, as well as for the colourimetric detection of glucose, compared to that of α-Fe2O3. We believe that this in-depth study of crystal structure based nanozyme activity will guide designing highly effective nanozymes based on iron oxide nanostructures for chemical sensing, biosensing and environmental remediation.

AB - Nanozymes (nanoparticles with enzyme-like properties) have attracted considerable attention in recent years owing to their intrinsic enzyme-like properties and broad application in the fields of ELISA based immunoassay and biosensing. Herein, we systematically investigate the influence of crystal phases (γ-Fe2O3 and α-Fe2O3) of mesoporous iron oxide (IO) on their peroxidase mimetic activity. In addition, we have also demonstrated the applicability of these mesoporous IOs as nanozymes for detecting the glucose biomarker with a limit of detection (LOD) of 0.9 μM. Mesoporous γ-Fe2O3 shows high nanozyme activities (and magnetism) toward the catalytic oxidation of chromogenic substances, such as 3,3′,5,5′-tetramethylbenzidine (TMB) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)-ABTS, as well as for the colourimetric detection of glucose, compared to that of α-Fe2O3. We believe that this in-depth study of crystal structure based nanozyme activity will guide designing highly effective nanozymes based on iron oxide nanostructures for chemical sensing, biosensing and environmental remediation.

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DO - 10.1039/c9tb00989b

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Nanoarchitectured peroxidase-mimetic nanozymes: Mesoporous nanocrystalline α- Or γ-iron oxide?

Abstract

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