Nanoarchitectured peroxidase-mimetic nanozymes: Mesoporous nanocrystalline α- Or γ-iron oxide?

Mostafa Kamal Masud, Jeonghun Kim, Md Motasim Billah, Kathleen Wood, Mohammad J.A. Shiddiky, Nam Trung Nguyen, Rajesh Kumar Parsapur, Yusuf Valentino Kaneti, Abdulmohsen Ali Alshehri, Yousef Gamaan Alghamidi, Khalid Ahmed Alzahrani, Murugulla Adharvanachari, Parasuraman Selvam, Md Shahriar A. Hossain, Yusuke Yamauchi

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22 Citations (Scopus)

Abstract

Nanozymes (nanoparticles with enzyme-like properties) have attracted considerable attention in recent years owing to their intrinsic enzyme-like properties and broad application in the fields of ELISA based immunoassay and biosensing. Herein, we systematically investigate the influence of crystal phases (γ-Fe2O3 and α-Fe2O3) of mesoporous iron oxide (IO) on their peroxidase mimetic activity. In addition, we have also demonstrated the applicability of these mesoporous IOs as nanozymes for detecting the glucose biomarker with a limit of detection (LOD) of 0.9 μM. Mesoporous γ-Fe2O3 shows high nanozyme activities (and magnetism) toward the catalytic oxidation of chromogenic substances, such as 3,3′,5,5′-tetramethylbenzidine (TMB) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)-ABTS, as well as for the colourimetric detection of glucose, compared to that of α-Fe2O3. We believe that this in-depth study of crystal structure based nanozyme activity will guide designing highly effective nanozymes based on iron oxide nanostructures for chemical sensing, biosensing and environmental remediation.

Original languageEnglish
Pages (from-to)5412-5422
Number of pages11
JournalJournal of Materials Chemistry B
Volume7
Issue number35
DOIs
Publication statusPublished - 2019

Bibliographical note

Funding Information:
This work was supported by the Australian Research Council (ARC) Discovery Project (DP190102944). This work was partially supported by the Australian Research Council (ARC) Future Fellow (FT150100479) to Y. Y., and Australian Government Research Training Program (RTP) Scholarship (the University of Queensland) to M. K. M. M. K. M. would also like to thank AINSE Limited for providing financial assistance (AINSE PGRA Award 2018). This work was partially performed at the Queensland node of the Australian National Fabrication Facility, a company established under the National Collaborative Research Infrastructure Strategy to provide nano-and micro-fabrication facilities for Australian researchers. The authors acknowledge the Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, for technical and financial support.

Publisher Copyright:
© 2019 The Royal Society of Chemistry.

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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