Nanocarriers as an emerging platform for cancer therapy

Dan Peer, Jeffrey M. Karp, Seungpyo Hong, Omid C. Farokhzad, Rimona Margalit, Robert Langer

Research output: Contribution to journalReview articlepeer-review

6009 Citations (Scopus)

Abstract

Nanotechnology has the potential to revolutionize cancer diagnosis and therapy. Advances in protein engineering and materials science have contributed to novel nanoscale targeting approaches that may bring new hope to cancer patients. Several therapeutic nanocarriers have been approved for clinical use. However, to date, there are only a few clinically approved nanocarriers that incorporate molecules to selectively bind and target cancer cells. This review examines some of the approved formulations and discusses the challenges in translating basic research to the clinic. We detail the arsenal of nanocarriers and molecules available for selective tumour targeting, and emphasize the challenges in cancer treatment.

Original languageEnglish
Pages (from-to)751-760
Number of pages10
JournalNature Nanotechnology
Volume2
Issue number12
DOIs
Publication statusPublished - 2007 Dec

Bibliographical note

Funding Information:
We would like to acknowledge Shiladitya Sengupta for critically reviewing the manuscript and Maeve Cullinane for helpful discussions. This work was supported by federal funds NIH/NCI CA119349, NIH/NIBIB EB 003647, and NIH R01-EB000244. The content is solely the responsibility of the authors and does not necessarily represent the official view of the NIH.

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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