Nanohybrids via a polycation-based nanoemulsion method for dual-mode detection of human mesenchymal stem cells

Sung Baek Seo; Jaemoon Yang; Eun Sook Lee; Yukyung Jung; Kyujung Kim; Sang Yup Lee; Donghyun Kim; Jin Suck Suh; Yong Min Huh; Seungjoo Haam

doi:10.1039/b804544e

Nanohybrids via a polycation-based nanoemulsion method for dual-mode detection of human mesenchymal stem cells

Sung Baek Seo, Jaemoon Yang, Eun Sook Lee, Yukyung Jung, Kyujung Kim, Sang Yup Lee, Donghyun Kim, Jin Suck Suh, Yong Min Huh, Seungjoo Haam

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14 Citations (Scopus)

Abstract

Fluorescent polycation-coated magnetic nanohybrids (FPMNs) were synthesized for the marking of human mesenchymal stem cells (hMSCs) and non-invasive tracking by both magnetic resonance (MR) and optical imaging. FPMNs were prepared by a polycation-based nanoemulsion method using magnetic nanocrystals (MNCs) as MR probes and polycationic polyethylenimine (PEI) which not only enhanced the affinity for hMSCs but also increased colloidal stability in the aqueous phase. Polycation-coated magnetic nanohybrids (PMNs) were further conjugated with a fluorescent dye (fluorescein isothiocyanate) to serve as optical imaging agents. FPMNs exhibited excellent colloidal stability and biocompatibility as well as high affinity for hMSCs. MR and optical images of hMSCs treated with FPMNs clearly demonstrated abundant potential as brilliant dual-mode imaging agents.

Original language	English
Pages (from-to)	4402-4407
Number of pages	6
Journal	Journal of Materials Chemistry
Volume	18
Issue number	37
DOIs	https://doi.org/10.1039/b804544e
Publication status	Published - 2008

All Science Journal Classification (ASJC) codes

Chemistry(all)
Materials Chemistry

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title = "Nanohybrids via a polycation-based nanoemulsion method for dual-mode detection of human mesenchymal stem cells",

abstract = "Fluorescent polycation-coated magnetic nanohybrids (FPMNs) were synthesized for the marking of human mesenchymal stem cells (hMSCs) and non-invasive tracking by both magnetic resonance (MR) and optical imaging. FPMNs were prepared by a polycation-based nanoemulsion method using magnetic nanocrystals (MNCs) as MR probes and polycationic polyethylenimine (PEI) which not only enhanced the affinity for hMSCs but also increased colloidal stability in the aqueous phase. Polycation-coated magnetic nanohybrids (PMNs) were further conjugated with a fluorescent dye (fluorescein isothiocyanate) to serve as optical imaging agents. FPMNs exhibited excellent colloidal stability and biocompatibility as well as high affinity for hMSCs. MR and optical images of hMSCs treated with FPMNs clearly demonstrated abundant potential as brilliant dual-mode imaging agents.",

author = "Seo, {Sung Baek} and Jaemoon Yang and Lee, {Eun Sook} and Yukyung Jung and Kyujung Kim and Lee, {Sang Yup} and Donghyun Kim and Suh, {Jin Suck} and Huh, {Yong Min} and Seungjoo Haam",

year = "2008",

doi = "10.1039/b804544e",

language = "English",

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publisher = "Royal Society of Chemistry",

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T1 - Nanohybrids via a polycation-based nanoemulsion method for dual-mode detection of human mesenchymal stem cells

AU - Seo, Sung Baek

AU - Yang, Jaemoon

AU - Lee, Eun Sook

AU - Jung, Yukyung

AU - Kim, Kyujung

AU - Lee, Sang Yup

AU - Kim, Donghyun

AU - Suh, Jin Suck

AU - Huh, Yong Min

AU - Haam, Seungjoo

PY - 2008

Y1 - 2008

N2 - Fluorescent polycation-coated magnetic nanohybrids (FPMNs) were synthesized for the marking of human mesenchymal stem cells (hMSCs) and non-invasive tracking by both magnetic resonance (MR) and optical imaging. FPMNs were prepared by a polycation-based nanoemulsion method using magnetic nanocrystals (MNCs) as MR probes and polycationic polyethylenimine (PEI) which not only enhanced the affinity for hMSCs but also increased colloidal stability in the aqueous phase. Polycation-coated magnetic nanohybrids (PMNs) were further conjugated with a fluorescent dye (fluorescein isothiocyanate) to serve as optical imaging agents. FPMNs exhibited excellent colloidal stability and biocompatibility as well as high affinity for hMSCs. MR and optical images of hMSCs treated with FPMNs clearly demonstrated abundant potential as brilliant dual-mode imaging agents.

AB - Fluorescent polycation-coated magnetic nanohybrids (FPMNs) were synthesized for the marking of human mesenchymal stem cells (hMSCs) and non-invasive tracking by both magnetic resonance (MR) and optical imaging. FPMNs were prepared by a polycation-based nanoemulsion method using magnetic nanocrystals (MNCs) as MR probes and polycationic polyethylenimine (PEI) which not only enhanced the affinity for hMSCs but also increased colloidal stability in the aqueous phase. Polycation-coated magnetic nanohybrids (PMNs) were further conjugated with a fluorescent dye (fluorescein isothiocyanate) to serve as optical imaging agents. FPMNs exhibited excellent colloidal stability and biocompatibility as well as high affinity for hMSCs. MR and optical images of hMSCs treated with FPMNs clearly demonstrated abundant potential as brilliant dual-mode imaging agents.

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DO - 10.1039/b804544e

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JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

IS - 37

ER -

Nanohybrids via a polycation-based nanoemulsion method for dual-mode detection of human mesenchymal stem cells

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