Nanomaterials for theranostics: Recent advances and future challenges

Eun Kyung Lim, Taekhoon Kim, Soonmyung Paik, Seungjoo Haam, Yong Min Huh, Kwangyeol Lee

Research output: Contribution to journalReview article

609 Citations (Scopus)

Abstract

Theranostics as a treatment strategy for individual patients encompasses a wide range of subjects, including personalized medicine, pharmacogenomics, and molecular imaging, in order to develop an efficient new targeted therapy and optimize drug selection via a better molecular understanding. Furthermore, theranostics aims to monitor the response to the treatment, to increase drug efficacy and safety, and to eliminate the unnecessary treatment of patients, resulting in significant cost savings for the overall healthcare system. Highly characteristic and nonrandom mutation patterns are found in well-studied oncogenes and tumor suppressor genes. Oncogenes are recurrently mutated at the same amino acid positions, leading to increased activity of the corresponding proteins.

Original languageEnglish
Pages (from-to)327-394
Number of pages68
JournalChemical Reviews
Volume115
Issue number1
DOIs
Publication statusPublished - 2015 Jan 14

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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