Nanomatrix Coated Stent Enhances Endothelialization but Reduces Platelet, Smooth Muscle Cell, and Monocyte Adhesion under Physiologic Conditions

G. C. Alexander, P. T.J. Hwang, J. Chen, J. Kim, B. C. Brott, Y. S. Yoon, H. W. Jun

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cardiovascular disease is presently the number one cause of death worldwide. Current stents used to treat cardiovascular disease have a litany of unacceptable shortcomings: adverse clinical events include restenosis, neointimal hyperplasia, thrombosis, inflammation, and poor re-endothelialization. We have developed a biocompatible, multifunctional, peptide amphiphile-based nanomatrix coating for stents. In this study, we evaluated the ability of the nanomatrix coated stent to simultaneously address the issues facing current stents under physiological flow conditions in vitro. We found that the nanomatrix coated stent could increase endothelial cell migration, adhesion, and proliferation (potential for re-endothelialization), discourage smooth muscle cell migration and adhesion (potential to reduce neointimal hyperplasia and restenosis), and decrease both platelet activation and adhesion (potential to prevent thrombosis) as well as monocyte adhesion (potential to attenuate inflammatory responses) under physiological flow conditions in vitro. These promising results demonstrate the potential clinical utility of this nanomatrix stent coating, and highlight the importance of biocompatibility, multifunctionality, and bioactivity in cardiovascular device design.

Original languageEnglish
Pages (from-to)107-115
Number of pages9
JournalACS Biomaterials Science and Engineering
Volume4
Issue number1
DOIs
Publication statusPublished - 2018 Jan 8

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

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