Nanoparticle-enabled terahertz imaging for cancer diagnosis

Seung Jae Oh, Jinyoung Kang, Inhee Maeng, Jinsuck Suh, yongmin Huh, Seungjoo Haam, Joo Hiuk Son

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

This paper demonstrates the principle of the nanoparticle-contrast-agent- enabled terahertz imaging (CATHI) technique, which yields a dramatic sensitivity of the differential signal from cancer cells with nanoparticles. The terahertz (THz) reflection signal increased beam by 20% in the cancer cells with nanoparticles of gold nano-rods (GNRs) upon their irradiation with a infrared (IR) laser, due to the temperature rise of water in cancer cells by surface plasma ploritons. In the differential mode, the THz signal from the cancer cells with GNRs was 30 times higher than that from the cancer cells without GNRs. As the high sensitivity is achieved by the surface plasmon resonance through IR laser irradiation, the resolution of the CATHI technique can be as good as a few microns and THz endoscopy becomes more feasible.

Original languageEnglish
Pages (from-to)3469-3475
Number of pages7
JournalOptics Express
Volume17
Issue number5
DOIs
Publication statusPublished - 2009 Mar 2

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cancer
nanoparticles
rods
gold
imaging techniques
infrared lasers
signal reflection
irradiation
sensitivity
surface plasmon resonance
water
temperature

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics

Cite this

Oh, Seung Jae ; Kang, Jinyoung ; Maeng, Inhee ; Suh, Jinsuck ; Huh, yongmin ; Haam, Seungjoo ; Son, Joo Hiuk. / Nanoparticle-enabled terahertz imaging for cancer diagnosis. In: Optics Express. 2009 ; Vol. 17, No. 5. pp. 3469-3475.
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Nanoparticle-enabled terahertz imaging for cancer diagnosis. / Oh, Seung Jae; Kang, Jinyoung; Maeng, Inhee; Suh, Jinsuck; Huh, yongmin; Haam, Seungjoo; Son, Joo Hiuk.

In: Optics Express, Vol. 17, No. 5, 02.03.2009, p. 3469-3475.

Research output: Contribution to journalArticle

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