Nanoparticles for multimodal in vivo imaging in nanomedicine

Jaehong Key, James F. Leary

Research output: Contribution to journalReview article

153 Citations (Scopus)

Abstract

While nanoparticles are usually designed for targeted drug delivery, they can also simultaneously provide diagnostic information by a variety of in vivo imaging methods. These diagnostic capabilities make use of specific properties of nanoparticle core materials. Near-infrared fluorescent probes provide optical detection of cells targeted by real-time nanoparticle-distribution studies within the organ compartments of live, anesthetized animals. By combining different imaging modalities, we can start with deep-body imaging by magnetic resonance imaging or computed tomography, and by using optical imaging, get down to the resolution required for real-time fluorescence-guided surgery.

Original languageEnglish
Pages (from-to)711-726
Number of pages16
JournalInternational journal of nanomedicine
Volume9
Issue number1
DOIs
Publication statusPublished - 2014 Jan 29

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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