Nanoplasmonic co-localization for highly sensitive surface plasmon resonance detection of molecular interactions

Youngjin Oh, Yonghwi Kim, Wonju Lee, Donghyun Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Surface plasmon resonance (SPR) has been applied to sensing biomolecular and drug interactions because it allows real-time monitoring and label-free detection. Traditional thin film based SPR biosensing suffers from moderate detection sensitivity. In this research, we investigate sensitivity enhancement by target colocalized SPR using various subwavelength nanostructures. The nanostructures were designed by calculating near-field distribution based on rigorous coupled-wave analysis. Experimentally, angled shadow evaporation was performed to fabricate the nanostructures for target colocalization and measured resonance shifts using angle scanning SPR. The feasibility was tested by measuring DNA hybridization. Experimental results confirm significantly enhanced detection sensitivity over traditional SPR techniques to be feasible. The results are expected to open a new approach to biomolecular detection based on SPR.

Original languageEnglish
Title of host publicationPlasmonics in Biology and Medicine X
Volume8597
DOIs
Publication statusPublished - 2013 May 30
EventPlasmonics in Biology and Medicine X - San Francisco, CA, United States
Duration: 2013 Feb 32013 Feb 4

Other

OtherPlasmonics in Biology and Medicine X
CountryUnited States
CitySan Francisco, CA
Period13/2/313/2/4

Fingerprint

Surface Plasmon Resonance
Molecular interactions
Surface plasmon resonance
molecular interactions
surface plasmon resonance
Nanostructures
Drug interactions
Drug Interactions
Labels
near fields
Evaporation
drugs
DNA
deoxyribonucleic acid
evaporation
Scanning
Thin films
scanning
augmentation
Monitoring

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Oh, Youngjin ; Kim, Yonghwi ; Lee, Wonju ; Kim, Donghyun. / Nanoplasmonic co-localization for highly sensitive surface plasmon resonance detection of molecular interactions. Plasmonics in Biology and Medicine X. Vol. 8597 2013.
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Oh, Y, Kim, Y, Lee, W & Kim, D 2013, Nanoplasmonic co-localization for highly sensitive surface plasmon resonance detection of molecular interactions. in Plasmonics in Biology and Medicine X. vol. 8597, 85970R, Plasmonics in Biology and Medicine X, San Francisco, CA, United States, 13/2/3. https://doi.org/10.1117/12.2004227

Nanoplasmonic co-localization for highly sensitive surface plasmon resonance detection of molecular interactions. / Oh, Youngjin; Kim, Yonghwi; Lee, Wonju; Kim, Donghyun.

Plasmonics in Biology and Medicine X. Vol. 8597 2013. 85970R.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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