Nanoporous multilayer films for controlled antigen protein release

Miso Yang, Daheui Choi, Moonhyun Choi, Jinkee Hong

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We have studied the preparation and characterization of nanoporous thin films fabricated from a layer by layer assembly of branched poly(ethylene imine), gold nanoparticles (gold NPs) and hyaluronic acid. Gold NPs embedded in the multilayer thin film structure were easily dissolved using an aqueous cyanide solution, generating the nanoporous film. This allows for the direct and precise comparison of the porosity of the polymer based multilayer thin films in both the presence and the absence of gold NPs. Additionally, the layer by layer (LbL) assembly method has advantages in that it increases the possibilities for mass production of multilayer films, and allows the precise control of film structures prepared on large substrates. Therefore, this method offers a new route to allow the introduction of nanoporosity into multilayer thin films, allowing the development of more complex functional multicomponent nanoporous structures for protein delivery. Furthermore, these novel materials could be used in biomedical applications.

Original languageEnglish
Pages (from-to)221-225
Number of pages5
JournalJournal of Industrial and Engineering Chemistry
Volume33
DOIs
Publication statusPublished - 2016 Jan 25

Fingerprint

Multilayer films
Antigens
Gold
Proteins
Thin films
Hyaluronic acid
Cyanides
Hyaluronic Acid
Polymers
Ethylene
Porosity
Nanoparticles
Substrates

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)

Cite this

@article{264b484d27834675bb0e7e86e0f382e0,
title = "Nanoporous multilayer films for controlled antigen protein release",
abstract = "We have studied the preparation and characterization of nanoporous thin films fabricated from a layer by layer assembly of branched poly(ethylene imine), gold nanoparticles (gold NPs) and hyaluronic acid. Gold NPs embedded in the multilayer thin film structure were easily dissolved using an aqueous cyanide solution, generating the nanoporous film. This allows for the direct and precise comparison of the porosity of the polymer based multilayer thin films in both the presence and the absence of gold NPs. Additionally, the layer by layer (LbL) assembly method has advantages in that it increases the possibilities for mass production of multilayer films, and allows the precise control of film structures prepared on large substrates. Therefore, this method offers a new route to allow the introduction of nanoporosity into multilayer thin films, allowing the development of more complex functional multicomponent nanoporous structures for protein delivery. Furthermore, these novel materials could be used in biomedical applications.",
author = "Miso Yang and Daheui Choi and Moonhyun Choi and Jinkee Hong",
year = "2016",
month = "1",
day = "25",
doi = "10.1016/j.jiec.2015.10.009",
language = "English",
volume = "33",
pages = "221--225",
journal = "Journal of Industrial and Engineering Chemistry",
issn = "1226-086X",
publisher = "Korean Society of Industrial Engineering Chemistry",

}

Nanoporous multilayer films for controlled antigen protein release. / Yang, Miso; Choi, Daheui; Choi, Moonhyun; Hong, Jinkee.

In: Journal of Industrial and Engineering Chemistry, Vol. 33, 25.01.2016, p. 221-225.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nanoporous multilayer films for controlled antigen protein release

AU - Yang, Miso

AU - Choi, Daheui

AU - Choi, Moonhyun

AU - Hong, Jinkee

PY - 2016/1/25

Y1 - 2016/1/25

N2 - We have studied the preparation and characterization of nanoporous thin films fabricated from a layer by layer assembly of branched poly(ethylene imine), gold nanoparticles (gold NPs) and hyaluronic acid. Gold NPs embedded in the multilayer thin film structure were easily dissolved using an aqueous cyanide solution, generating the nanoporous film. This allows for the direct and precise comparison of the porosity of the polymer based multilayer thin films in both the presence and the absence of gold NPs. Additionally, the layer by layer (LbL) assembly method has advantages in that it increases the possibilities for mass production of multilayer films, and allows the precise control of film structures prepared on large substrates. Therefore, this method offers a new route to allow the introduction of nanoporosity into multilayer thin films, allowing the development of more complex functional multicomponent nanoporous structures for protein delivery. Furthermore, these novel materials could be used in biomedical applications.

AB - We have studied the preparation and characterization of nanoporous thin films fabricated from a layer by layer assembly of branched poly(ethylene imine), gold nanoparticles (gold NPs) and hyaluronic acid. Gold NPs embedded in the multilayer thin film structure were easily dissolved using an aqueous cyanide solution, generating the nanoporous film. This allows for the direct and precise comparison of the porosity of the polymer based multilayer thin films in both the presence and the absence of gold NPs. Additionally, the layer by layer (LbL) assembly method has advantages in that it increases the possibilities for mass production of multilayer films, and allows the precise control of film structures prepared on large substrates. Therefore, this method offers a new route to allow the introduction of nanoporosity into multilayer thin films, allowing the development of more complex functional multicomponent nanoporous structures for protein delivery. Furthermore, these novel materials could be used in biomedical applications.

UR - http://www.scopus.com/inward/record.url?scp=84951737937&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84951737937&partnerID=8YFLogxK

U2 - 10.1016/j.jiec.2015.10.009

DO - 10.1016/j.jiec.2015.10.009

M3 - Article

AN - SCOPUS:84951737937

VL - 33

SP - 221

EP - 225

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

SN - 1226-086X

ER -