Nanoporous multilayer films for controlled antigen protein release

Miso Yang; Daheui Choi; Moonhyun Choi; Jinkee Hong

doi:10.1016/j.jiec.2015.10.009

Nanoporous multilayer films for controlled antigen protein release

Miso Yang, Daheui Choi, Moonhyun Choi, Jinkee Hong

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

We have studied the preparation and characterization of nanoporous thin films fabricated from a layer by layer assembly of branched poly(ethylene imine), gold nanoparticles (gold NPs) and hyaluronic acid. Gold NPs embedded in the multilayer thin film structure were easily dissolved using an aqueous cyanide solution, generating the nanoporous film. This allows for the direct and precise comparison of the porosity of the polymer based multilayer thin films in both the presence and the absence of gold NPs. Additionally, the layer by layer (LbL) assembly method has advantages in that it increases the possibilities for mass production of multilayer films, and allows the precise control of film structures prepared on large substrates. Therefore, this method offers a new route to allow the introduction of nanoporosity into multilayer thin films, allowing the development of more complex functional multicomponent nanoporous structures for protein delivery. Furthermore, these novel materials could be used in biomedical applications.

Original language	English
Pages (from-to)	221-225
Number of pages	5
Journal	Journal of Industrial and Engineering Chemistry
Volume	33
DOIs	https://doi.org/10.1016/j.jiec.2015.10.009
Publication status	Published - 2016 Jan 25

Bibliographical note

Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation of Korea (NRF), funded by the Korean government No. 2012M3A9C6050104 ). Also, this work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government Ministry of Science, ICT & Future Planning (No. 2013R1A1A1076126 ). Additionally, this work was carried out with the support of “Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ009986012015)” ( Rural Development Administration, Republic of Korea ), as well as the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare ( HI14C-3266-030014 ). This work was also supported by the Chung-Ang University Excellent Student Scholarship in 2015.

All Science Journal Classification (ASJC) codes

Chemical Engineering(all)

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title = "Nanoporous multilayer films for controlled antigen protein release",

abstract = "We have studied the preparation and characterization of nanoporous thin films fabricated from a layer by layer assembly of branched poly(ethylene imine), gold nanoparticles (gold NPs) and hyaluronic acid. Gold NPs embedded in the multilayer thin film structure were easily dissolved using an aqueous cyanide solution, generating the nanoporous film. This allows for the direct and precise comparison of the porosity of the polymer based multilayer thin films in both the presence and the absence of gold NPs. Additionally, the layer by layer (LbL) assembly method has advantages in that it increases the possibilities for mass production of multilayer films, and allows the precise control of film structures prepared on large substrates. Therefore, this method offers a new route to allow the introduction of nanoporosity into multilayer thin films, allowing the development of more complex functional multicomponent nanoporous structures for protein delivery. Furthermore, these novel materials could be used in biomedical applications.",

author = "Miso Yang and Daheui Choi and Moonhyun Choi and Jinkee Hong",

note = "Funding Information: This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation of Korea (NRF), funded by the Korean government No. 2012M3A9C6050104 ). Also, this work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government Ministry of Science, ICT & Future Planning (No. 2013R1A1A1076126 ). Additionally, this work was carried out with the support of “Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ009986012015)” ( Rural Development Administration, Republic of Korea ), as well as the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare ( HI14C-3266-030014 ). This work was also supported by the Chung-Ang University Excellent Student Scholarship in 2015. ",

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